Improving the health and wellbeing of poorly housed Australians: understanding and responding to multiple housing deficit. Australia is currently in a housing crisis, with many escalating problems, including poor affordability, chronic undersupply, homelessness, insecurity in the private rental market and a shrinking public housing sector. While some Australians are unaffected, increasing numbers of already vulnerable people experience multiple housing problems. This project aims to develop a ne ....Improving the health and wellbeing of poorly housed Australians: understanding and responding to multiple housing deficit. Australia is currently in a housing crisis, with many escalating problems, including poor affordability, chronic undersupply, homelessness, insecurity in the private rental market and a shrinking public housing sector. While some Australians are unaffected, increasing numbers of already vulnerable people experience multiple housing problems. This project aims to develop a new theoretical framework for focusing on Australians who experience multiple housing problems. It aims to identify who will be affected, how this will play out on individual health and wellbeing, and how governments can best respond. It will provide essential evidence and intervention tools for understanding and improving the lives of the most vulnerable.Read moreRead less
Pathways for Indigenous and Western knowledge into Environmental Policy. The aim of this project is to identify the ways in which all knowledge, particularly Western and Indigenous knowledges can work together to inform environmental policy, with a focus on climate change adaptation. Using participatory methodologies and supported by an Indigenous led advisory group, the project will partner with Indigenous Ranger groups to interrogate three key knowledge management concepts: integration, co-pro ....Pathways for Indigenous and Western knowledge into Environmental Policy. The aim of this project is to identify the ways in which all knowledge, particularly Western and Indigenous knowledges can work together to inform environmental policy, with a focus on climate change adaptation. Using participatory methodologies and supported by an Indigenous led advisory group, the project will partner with Indigenous Ranger groups to interrogate three key knowledge management concepts: integration, co-production and co-existence. Based on communities of practice, in the Kati Thanda-Lake Eyre Basin, Australia, the Fellowship seeks to produce mechanisms of knowledge co-existence and maintenance that will contribute to stronger environmental policies and create spaces for Indigenous voices to be represented within them.Read moreRead less
Molecular hallmarks of androgen receptor targeting in prostate cancer. There is a critical need in oncology drug development for better biomarkers of response to prostate cancer therapies, clinically to assist with treatment decision making, and pre-clinically to facilitate translation of emerging agents into clinical practice. Using a unique explant culture model, this project will identify protein and lipid markers that can be used to accurately and reliably assess response to androgen recepto ....Molecular hallmarks of androgen receptor targeting in prostate cancer. There is a critical need in oncology drug development for better biomarkers of response to prostate cancer therapies, clinically to assist with treatment decision making, and pre-clinically to facilitate translation of emerging agents into clinical practice. Using a unique explant culture model, this project will identify protein and lipid markers that can be used to accurately and reliably assess response to androgen receptor (AR)-targeting therapies in human prostate tumours. The identification and functional assessment of these biomarkers will identify those that can be used as surrogate endpoints in clinical trials, facilitate earlier approval of investigational agents and lead to improved options for therapeutic management of prostate cancer.Read moreRead less
How do mechanical cues regulate tissue renewal and tumour progression? Imbalances between cell production and cell death in tissues can be catastrophic, leading to major global health issues such as cancer. This project will use modified mice and protein-protein interaction based techniques to identify how changes in the mechanical properties of tissues regulate the balance between cell production and cell death.
Light-responsive nanomaterials as nanomedicines: new approaches to treating macular degeneration, cancer and other critical unmet therapeutic needs. Nanotechnology is enabling new medicines for the treatment of important diseases such as cancer and macular degeneration. This project will investigate novel nanomaterials for the development of new highly effective medicines that can be controlled after administration, leading to reduced side effects and increased convenience for patients.
Critical conversations: An ethnographic study of Australian organ donation. There is an urgent need for new culturally sensitive ways of improving organ donation rates in Australia, which are lower in culturally and linguistically diverse groups. The project aims to reorient the research focus from decisions made prior to death to the actual times and clinical spaces in which these decisions occur. Through a comparative cross-cultural analysis this research will provide essential knowledge that ....Critical conversations: An ethnographic study of Australian organ donation. There is an urgent need for new culturally sensitive ways of improving organ donation rates in Australia, which are lower in culturally and linguistically diverse groups. The project aims to reorient the research focus from decisions made prior to death to the actual times and clinical spaces in which these decisions occur. Through a comparative cross-cultural analysis this research will provide essential knowledge that will inform innovative approaches to understanding organ donation. The outcomes will have a strong bearing on how organ donation communication, professional protocols, and ultimately, organ donation practice evolve in Australia. Read moreRead less
Australian family diversity: Individual experiences and public attitudes. Whilst Australian families continue to diversify, public perceptions and policies related to families appear entrenched in a normative understanding of family. This project will provide a genealogy of public and policy accounts of Australian families, map public perceptions of a diverse range of family structures and modes of family formation, and identify how differing cohorts of Australian families talk about their famil ....Australian family diversity: Individual experiences and public attitudes. Whilst Australian families continue to diversify, public perceptions and policies related to families appear entrenched in a normative understanding of family. This project will provide a genealogy of public and policy accounts of Australian families, map public perceptions of a diverse range of family structures and modes of family formation, and identify how differing cohorts of Australian families talk about their families. Together, these strands will produce a unified body of knowledge about Australian families that will allow for the identification of factors influencing public perceptions, and thus the development of policy initiatives aimed at recognising family diversity and challenging social norms.Read moreRead less
Food/body encounters: New approaches and alternative solutions to obesity prevention and policy. There is growing recognition of the need for new ways to tackle the obesity problem, and for forms of intervention that move beyond the limitations of individual behavioural changes. This project provides a paradigm for re-orientating how we have come to know obesity by investigating the cultural and institutional processes that shape everyday food and activity practices. Understanding and intervenin ....Food/body encounters: New approaches and alternative solutions to obesity prevention and policy. There is growing recognition of the need for new ways to tackle the obesity problem, and for forms of intervention that move beyond the limitations of individual behavioural changes. This project provides a paradigm for re-orientating how we have come to know obesity by investigating the cultural and institutional processes that shape everyday food and activity practices. Understanding and intervening in these dynamics of social practice are central to the challenges of reversing trends in the prevalence of obesity.Read moreRead less
Generations through prison: a critical exploration of the causes, experiences, and consequences of intergenerational incarceration. Around one third of the 30,000 prisoners in Australia are children or relatives of former prisoners, but very little is known about the causes, experiences and impacts of intergenerational incarceration. This project will redress this research deficit and help prevent the disproportionate recurrence of incarceration in particular familial lineages.
The transcriptional control of lymphatic vessel development. Lymphatic vessels are a vital, but often overlooked, component of the cardiovascular system. These specialised vessels return tissue fluid to the bloodstream, absorb dietary lipids and transport cells of the immune system throughout the body. Defects in the growth and development of lymphatic vessels result in disorders including lymphedema, obesity, inflammatory diseases and cancer. This project aims to define how transcription factor ....The transcriptional control of lymphatic vessel development. Lymphatic vessels are a vital, but often overlooked, component of the cardiovascular system. These specialised vessels return tissue fluid to the bloodstream, absorb dietary lipids and transport cells of the immune system throughout the body. Defects in the growth and development of lymphatic vessels result in disorders including lymphedema, obesity, inflammatory diseases and cancer. This project aims to define how transcription factors program lymphatic vessel identity and control the development of lymphatic vessel valves. This knowledge will provide new insight into the fundamental mechanisms by which the lymphatic vasculature is constructed during development.Read moreRead less