A Randomised Placebo-controlled Trial Of Antibiotics To Prevent Urinary Tract Infection In Children
Funder
National Health and Medical Research Council
Funding Amount
$735,000.00
Summary
This study is needed to determine whether a common clinical practice long-term antibiotic treatment for children following urinary tract infection (UTI) - is safe and effective in preventing further UTI and if so, whether all appropriate children are being treated. UTI will affect about 10% of Australian children by high school age (88,000 children per year). Because UTI may damage the kidneys, the management priority for children with UTI has been prevention of further infection. Currently this ....This study is needed to determine whether a common clinical practice long-term antibiotic treatment for children following urinary tract infection (UTI) - is safe and effective in preventing further UTI and if so, whether all appropriate children are being treated. UTI will affect about 10% of Australian children by high school age (88,000 children per year). Because UTI may damage the kidneys, the management priority for children with UTI has been prevention of further infection. Currently this means the identification of children thought to be most at risk of recurrent UTI by renal tract imaging. Those found to have reflux of urine from the bladder to the kidney (present in about 30% of those with UTI) are then placed on antibiotics fro 2-5 years. Unfortunately there has never been a properly designed trial to test whether antibiotics do really prevent UTI and if so, whether children with reflux are the appropriate and only group requiring treatment. Long term antibiotics may in fact do more harm than good because of side effects like skin, bowel and blood problems and because resistant bacteria may develop. The design of this study involves the random allocation of placebo or antibiotic (cotrimoxazole, the usual antibiotic given in this case) to about 800 children after their first symptomatic UTI. These children are treated and followed for one year to determine the rate of futher UTI in both groups. Any difference in outcome between the two groups of children will be because of the antibiotic treatment. This study may prove long-term antibiotics are ineffective and therefore should not be routinely used. In this case investigation of children to detect vesicoureteric reflux would serve little purpose and should be abandoned. Alternatively antibiotic treatment may be shown as effective treatment for preventing further UTI and in this case the study will clearly identify those children who will benefit.Read moreRead less
Discovery Indigenous Researchers Development - Grant ID: DI100100297
Funder
Australian Research Council
Funding Amount
$158,000.00
Summary
Archaeology in the long grass: A study of Aboriginal fringe camp sites in the urban hinterland around Darwin, Australia. This research will contribute to the priority goal of strengthening Australia's social and economic fabric by: 1) advancing the government priority policy commitment to close the gap of Indigenous disadvantage by contributing to social and economic improvements for Indigenous people living in the long grass around Darwin, and other urban centres; 2) contributing to native titl ....Archaeology in the long grass: A study of Aboriginal fringe camp sites in the urban hinterland around Darwin, Australia. This research will contribute to the priority goal of strengthening Australia's social and economic fabric by: 1) advancing the government priority policy commitment to close the gap of Indigenous disadvantage by contributing to social and economic improvements for Indigenous people living in the long grass around Darwin, and other urban centres; 2) contributing to native title debates; 3) developing the research capacity of Indigenous Australians; and 4) increasing public understandings of Aboriginal culture. The Larrakia Nation Aboriginal Corporation will benefit from enhanced research capacity through the quality training of research associates and new data to inform policy decisions and recommendations.Read moreRead less
Improving Sub-national Population Forecasts. The aim of this project is to make significant advances in two related areas of regional, council area and local population forecasting, namely improving accuracy, and providing an indication of forecast uncertainty. Population forecasts often turn out to be far more inaccurate than users realise and fail to come with any information about reliability. Every year forecasts inform a wide variety of planning and policy development activities and influen ....Improving Sub-national Population Forecasts. The aim of this project is to make significant advances in two related areas of regional, council area and local population forecasting, namely improving accuracy, and providing an indication of forecast uncertainty. Population forecasts often turn out to be far more inaccurate than users realise and fail to come with any information about reliability. Every year forecasts inform a wide variety of planning and policy development activities and influence investment decisions worth billions of dollars. In order to increase the value of forecasts to users, this project aims to combine methods from a range of disciplines to devise more accurate ways of forecasting populations, and provide accompanying information on their likely error.Read moreRead less
Families and generational asset transfers: making and challenging wills in contemporary Australia. This project, in collaboration with Public Trust offices across Australia, will provide a national database on which sectors of the population fail to make wills and why. The results will inform innovative service models, law reform initiatives and public education campaigns.
First Nations AI: Country, Climate, Communication. Our team of Indigenous and western scholars aims to develop a systematic account of artificial intelligence and its possibilities in climate change communication in remote First Nations communities in northern Australia. Working under Indigenous governance, we will establish spaces for Indigenous landowners and scientists to come together to probe diverse AI techniques for making sense of climate predictions and risks. We will build the capacity ....First Nations AI: Country, Climate, Communication. Our team of Indigenous and western scholars aims to develop a systematic account of artificial intelligence and its possibilities in climate change communication in remote First Nations communities in northern Australia. Working under Indigenous governance, we will establish spaces for Indigenous landowners and scientists to come together to probe diverse AI techniques for making sense of climate predictions and risks. We will build the capacity of Indigenous people to conceive and design AI, accounting for divergent languages and knowledge systems. This is expected to lead to more effective and trustworthy communications about extreme weather and climate change, improving the preparedness and responses of remote First Nations communities.Read moreRead less
Creative Tropical City: Mapping Darwin's Creative Industries. This research will improve our knowledge and understanding of the creative industries in Darwin. It will provide a strong evidence base for the development of policy options for growing the creative industries in Darwin. And it will interrogate national and international creative industry policy frameworks for their applicability to Darwin.
Strategies to reduce risk of heat induced illness during intermittent, high intensity activity in a tropical environment. Regular intermittent, high intensity physical activity (IHIA) affords protection against modern life-style diseases (type II diabetes, coronary heart disease and some cancers) but when conducted in the tropics, exposes persons to the risk of dehydration, heat cramps, hypotension, heat syncope, heat exhaustion and heat stroke. Australia has rapid population growth in the tropi ....Strategies to reduce risk of heat induced illness during intermittent, high intensity activity in a tropical environment. Regular intermittent, high intensity physical activity (IHIA) affords protection against modern life-style diseases (type II diabetes, coronary heart disease and some cancers) but when conducted in the tropics, exposes persons to the risk of dehydration, heat cramps, hypotension, heat syncope, heat exhaustion and heat stroke. Australia has rapid population growth in the tropics and key sporting fixtures have moved to the region. We have set up the research capability and must now move on a range of IHIA in sport, workplaces, armed and emergency services to provide strategies to reduce the risk of heat induced illness in a tropical environment.Read moreRead less
About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock a ....About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock and its role in the normal biology of the heart. New data will significantly enhance our understanding of the biology of MR and cortisol for the circadian time keeping function in peripheral tissues, and gain a clearer understand how our heart cells adapt to environmental circadian disruptors such as shift work. Read moreRead less
The demographic consequences of migration to, from and within Australia. The long-term demographic consequences of migration to, from and within Australia, and the dynamic pathways that produced them, will be studied. This will involve the identification of the specific contributions made by international and internal migration to the age and sex population compositions of nine birthplace-specific populations from 1981 to 2011. To do this, publically available data will be collected and augmente ....The demographic consequences of migration to, from and within Australia. The long-term demographic consequences of migration to, from and within Australia, and the dynamic pathways that produced them, will be studied. This will involve the identification of the specific contributions made by international and internal migration to the age and sex population compositions of nine birthplace-specific populations from 1981 to 2011. To do this, publically available data will be collected and augmented with statistical methods to provide a complete, consistent account of population change for around 60 subnational areas. As migration and population change underpins many aspects of societal change in Australia, this research aims to provide an invaluable resource to other scientists and policy makers.Read moreRead less
Gambling-related harm in Northern Australia: A Geographic Information Systems (GIS)-based spatiotemporal analysis of venue catchments. There is growing national concern about the impact of electronic gaming (poker) machines yet little is known about the effects of this gambling in rural and remote areas of Australia. We will develop a database to define the geographic distribution of gambling impacts, the nature of high-risk venues, and the characteristics, both spatial and social, of vulnerable ....Gambling-related harm in Northern Australia: A Geographic Information Systems (GIS)-based spatiotemporal analysis of venue catchments. There is growing national concern about the impact of electronic gaming (poker) machines yet little is known about the effects of this gambling in rural and remote areas of Australia. We will develop a database to define the geographic distribution of gambling impacts, the nature of high-risk venues, and the characteristics, both spatial and social, of vulnerable communities. This will enable the design of much needed harm minimisation strategies and will provide regulatory bodies with insights into the capacity of local communities to absorb the impact of electronic gaming machine venues.Read moreRead less