A Randomised Placebo-controlled Trial Of Antibiotics To Prevent Urinary Tract Infection In Children
Funder
National Health and Medical Research Council
Funding Amount
$735,000.00
Summary
This study is needed to determine whether a common clinical practice long-term antibiotic treatment for children following urinary tract infection (UTI) - is safe and effective in preventing further UTI and if so, whether all appropriate children are being treated. UTI will affect about 10% of Australian children by high school age (88,000 children per year). Because UTI may damage the kidneys, the management priority for children with UTI has been prevention of further infection. Currently this ....This study is needed to determine whether a common clinical practice long-term antibiotic treatment for children following urinary tract infection (UTI) - is safe and effective in preventing further UTI and if so, whether all appropriate children are being treated. UTI will affect about 10% of Australian children by high school age (88,000 children per year). Because UTI may damage the kidneys, the management priority for children with UTI has been prevention of further infection. Currently this means the identification of children thought to be most at risk of recurrent UTI by renal tract imaging. Those found to have reflux of urine from the bladder to the kidney (present in about 30% of those with UTI) are then placed on antibiotics fro 2-5 years. Unfortunately there has never been a properly designed trial to test whether antibiotics do really prevent UTI and if so, whether children with reflux are the appropriate and only group requiring treatment. Long term antibiotics may in fact do more harm than good because of side effects like skin, bowel and blood problems and because resistant bacteria may develop. The design of this study involves the random allocation of placebo or antibiotic (cotrimoxazole, the usual antibiotic given in this case) to about 800 children after their first symptomatic UTI. These children are treated and followed for one year to determine the rate of futher UTI in both groups. Any difference in outcome between the two groups of children will be because of the antibiotic treatment. This study may prove long-term antibiotics are ineffective and therefore should not be routinely used. In this case investigation of children to detect vesicoureteric reflux would serve little purpose and should be abandoned. Alternatively antibiotic treatment may be shown as effective treatment for preventing further UTI and in this case the study will clearly identify those children who will benefit.Read moreRead less
Creative Tropical City: Mapping Darwin's Creative Industries. This research will improve our knowledge and understanding of the creative industries in Darwin. It will provide a strong evidence base for the development of policy options for growing the creative industries in Darwin. And it will interrogate national and international creative industry policy frameworks for their applicability to Darwin.
Gambling-related harm in Northern Australia: A Geographic Information Systems (GIS)-based spatiotemporal analysis of venue catchments. There is growing national concern about the impact of electronic gaming (poker) machines yet little is known about the effects of this gambling in rural and remote areas of Australia. We will develop a database to define the geographic distribution of gambling impacts, the nature of high-risk venues, and the characteristics, both spatial and social, of vulnerable ....Gambling-related harm in Northern Australia: A Geographic Information Systems (GIS)-based spatiotemporal analysis of venue catchments. There is growing national concern about the impact of electronic gaming (poker) machines yet little is known about the effects of this gambling in rural and remote areas of Australia. We will develop a database to define the geographic distribution of gambling impacts, the nature of high-risk venues, and the characteristics, both spatial and social, of vulnerable communities. This will enable the design of much needed harm minimisation strategies and will provide regulatory bodies with insights into the capacity of local communities to absorb the impact of electronic gaming machine venues.Read moreRead less
Special Research Initiatives - Grant ID: SR200200605
Funder
Australian Research Council
Funding Amount
$247,683.00
Summary
Australian Boys: Beyond the Boy Problem. In Australia, most research on boys and boyhood is focused on risk-reduction, representing boys as problems at school, on the streets, or in relationships, with an ambivalent (if not oppositional) relation to feminism. At the same time, anti-feminist public discourse highlighting the experiences of boys and young men is used to justify violence towards women as well as call for the reversal of social changes that have expanded opportunities available to g ....Australian Boys: Beyond the Boy Problem. In Australia, most research on boys and boyhood is focused on risk-reduction, representing boys as problems at school, on the streets, or in relationships, with an ambivalent (if not oppositional) relation to feminism. At the same time, anti-feminist public discourse highlighting the experiences of boys and young men is used to justify violence towards women as well as call for the reversal of social changes that have expanded opportunities available to girls. This research project will develop a framework for interdisciplinary research that takes Australian boys and boyhood as the subjects of a more inclusive future, working to overcome ingrained oppositions between feminist scholarship and the lives and interests of boys. Read moreRead less
Aboriginal place names and ethnobiology: enhancing interpretation of Indigenous culture and heritage. This project looks at how Indigenous people’s knowledge of place names and bush tucker can create opportunities for Indigenous communities in areas such as tourism. The project aims to do this by harnessing new advances in digital media which offer new ways of passing on this knowledge to both Indigenous and intercultural audiences.
Where migrants go: A study of immigrants' post-arrival moves in Australia . The project aims to establish the geographical and occupational trajectories of different migrant groups after arrival in Australia. Migration within Australia is a key driver of economic, demographic and social change. Recognising the growing diversity of immigrants, including the rapid rise in temporary migration, the project examines post-arrival moves of immigrants by visa type, country of birth and year of arrival. ....Where migrants go: A study of immigrants' post-arrival moves in Australia . The project aims to establish the geographical and occupational trajectories of different migrant groups after arrival in Australia. Migration within Australia is a key driver of economic, demographic and social change. Recognising the growing diversity of immigrants, including the rapid rise in temporary migration, the project examines post-arrival moves of immigrants by visa type, country of birth and year of arrival. It seeks to improve understanding of the incidence, spatial patterns and drivers of migrants’ movement within Australia and the socio-demographic impact on regions and individuals. Such understanding is an essential first step to the formulation of effective immigration and settlement policies and programs.Read moreRead less
An empirically-derived conceptual framework for designing usable and useful wireless mobile applications. The technological challenges posed by mobile computing devices have taken priority over the issues of appropriate use and usability that will ultimately determine their success in real work environments.
This project investigates these issues, particularly the role played by the context of use in the usability and usefulness of mobile applications.
The project's aims will be realised ....An empirically-derived conceptual framework for designing usable and useful wireless mobile applications. The technological challenges posed by mobile computing devices have taken priority over the issues of appropriate use and usability that will ultimately determine their success in real work environments.
This project investigates these issues, particularly the role played by the context of use in the usability and usefulness of mobile applications.
The project's aims will be realised through ethnographic studies of mobile work practice, representative use scenarios and the development of an empirically grounded conceptual framework that can guide the design of usable mobile applications.
The results will increase the successful utilisation of mobile technology by Australian industries.
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Modelling the Causes of Regional Disparities across Australia. This project aims to explain the changing patterns of regional economic performance across Australia between 2001-2011 in the context of two developments: major structural shifts in world trade and commodity prices spawning massive mining growth and negative exchange rate impacts elsewhere (for example, manufacturing); and the financial crisis ending the credit boom leaving east coast economies struggling. The resulting regional disp ....Modelling the Causes of Regional Disparities across Australia. This project aims to explain the changing patterns of regional economic performance across Australia between 2001-2011 in the context of two developments: major structural shifts in world trade and commodity prices spawning massive mining growth and negative exchange rate impacts elsewhere (for example, manufacturing); and the financial crisis ending the credit boom leaving east coast economies struggling. The resulting regional disparities have policy implications for education and skills training, housing affordability, infrastructure provision, and community sustainability. These issues will be investigated using a new functional economic regions geography and state of art spatial modelling tools supplemented by regional case studies.Read moreRead less
Predicting the diagnostic performance of individuals and organisations. Predicting the diagnostic performance of individuals and organisations. This project aims to address diagnostic error in advanced technology systems, by providing a mechanism to assess and improve individual diagnosticians’ performance. Organisations that rely on their employees’ diagnostic skills rarely assess them once the operators become qualified, so there is no basis for interventions that might prevent diagnostic erro ....Predicting the diagnostic performance of individuals and organisations. Predicting the diagnostic performance of individuals and organisations. This project aims to address diagnostic error in advanced technology systems, by providing a mechanism to assess and improve individual diagnosticians’ performance. Organisations that rely on their employees’ diagnostic skills rarely assess them once the operators become qualified, so there is no basis for interventions that might prevent diagnostic errors affecting thousands. This research tests a new method of assessing diagnostic skills based on how skilled operators respond to cues. This project will test how employees’ diagnostic skills change and whether this change corresponds to measures of organisational performance. This research is expected to provide organisations with a tool to pre-empt diagnostic errors that could minimise costs to the economy.Read moreRead less
Transformations in Aboriginal central Australia: A study of Warlpiri social relations in a time of crisis. By investigating the deterioration of social relations currently experienced by Warlpiri people at the settlement of Yuendumu, this project develops a paradigmatic case study contributing towards better understanding contemporary Aboriginal Australia. It explores on-the-ground realities and historical material to identify patterns underlying the transformations of social relations. It analy ....Transformations in Aboriginal central Australia: A study of Warlpiri social relations in a time of crisis. By investigating the deterioration of social relations currently experienced by Warlpiri people at the settlement of Yuendumu, this project develops a paradigmatic case study contributing towards better understanding contemporary Aboriginal Australia. It explores on-the-ground realities and historical material to identify patterns underlying the transformations of social relations. It analyses these and their effects through an innovative conceptual framework integrating anthropological approaches with the interdisciplinary study of the emotions. The outcomes will considerably further current developments in Australian anthropology and it will make a timely qualitative contribution to current public debates about Aboriginal policy.Read moreRead less