Theoretical and experimental studies on magnetoelectroelastic bone remodelling process. The project combines biotechnology and material science which will have national economic, social and environment impact. It can benefit industry by providing knowledge that help scientists understand remodeling under coupled fields and is used to develop bone replacement. By better understanding remodeling due to multi-field loading, we can assist scientists in aeronautical industry in developing countermeas ....Theoretical and experimental studies on magnetoelectroelastic bone remodelling process. The project combines biotechnology and material science which will have national economic, social and environment impact. It can benefit industry by providing knowledge that help scientists understand remodeling under coupled fields and is used to develop bone replacement. By better understanding remodeling due to multi-field loading, we can assist scientists in aeronautical industry in developing countermeasures that reduce or eliminate bone loss resulting from long-duration space flight. It can provide knowledge that can be used to explore underlying mechanisms controlling bone remodeling and self-repair in gaining insight into debilitating diseases such as osteoporosis, to develop high-performance prosthetics for medical injury healing.Read moreRead less
Molecular dissection of the effects of alpha-actinin-3 deficiency on normal variation in skeletal muscle function. We will study the mechanisms by which a common genetic variant influences muscle bulk, muscle strength and the metabolic efficiency of muscle in the general population. Common genetic variants that influence skeletal muscle function have major potential public health implications as they are likely to influence individuals' response to exercise and diet, and to contribute to suscept ....Molecular dissection of the effects of alpha-actinin-3 deficiency on normal variation in skeletal muscle function. We will study the mechanisms by which a common genetic variant influences muscle bulk, muscle strength and the metabolic efficiency of muscle in the general population. Common genetic variants that influence skeletal muscle function have major potential public health implications as they are likely to influence individuals' response to exercise and diet, and to contribute to susceptibility to common diseases such as obesity, diabetes, and the loss of muscle strength in the elderly. In addition, the identification of genetic factors that influence muscle bulk in vertebrates has implications for breeding programs in sheep and cattle and may provide commercial benefit to the livestock industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882682
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
The Australasian Pollen and Spore Atlas. The results generated in this project will enhance Australian research capabilities across multiple disciplines by providing access to key knowledge of pollen and spores in our region. A unified approach to the archiving, presentation and accessibility to existing and evolving databases will provide a considerably improved context for identification and knowledge pooling of any given pollen or spore type. This will create a nexus for novel interactions be ....The Australasian Pollen and Spore Atlas. The results generated in this project will enhance Australian research capabilities across multiple disciplines by providing access to key knowledge of pollen and spores in our region. A unified approach to the archiving, presentation and accessibility to existing and evolving databases will provide a considerably improved context for identification and knowledge pooling of any given pollen or spore type. This will create a nexus for novel interactions between researchers and end users of these data from within and beyond Australia's borders.Read moreRead less
Special Research Initiatives - Grant ID: SR0567379
Funder
Australian Research Council
Funding Amount
$110,000.00
Summary
The Australasian Pollen and Spore Atlas. This proposal will enable online accessibility to the largest collection of pollen and spores information in the Australasian region that is currently located at the Australian National University. This will be a searchable database that is accessible over the web and suitable for professional as well as the technical novice involved in pollen and spore identification. Novel approaches to the federation of other smaller existing pollen and spores database ....The Australasian Pollen and Spore Atlas. This proposal will enable online accessibility to the largest collection of pollen and spores information in the Australasian region that is currently located at the Australian National University. This will be a searchable database that is accessible over the web and suitable for professional as well as the technical novice involved in pollen and spore identification. Novel approaches to the federation of other smaller existing pollen and spores databases will result in The Australasian Pollen and Spores Atlas. The Atlas will be a flexible and powerful knowledge management tool applicable to research development by a wide range of users including those within the archaeology, biology, geology, and airborne allergy specialists.Read moreRead less
The Evolution of the Social Brain: How Emotions and Moral Judgement Interact in the Generation of Cooperative Behaviour. Understanding the psychological forces that underpin human interactions is a necessary step to knowing how to improve those interactions. Comprehending the complex interplay of emotions and moral judgements lying behind decision-making in the social sphere will help explain such things as corruption, risk-taking, domestic violence, and political affiliation. Such knowledge can ....The Evolution of the Social Brain: How Emotions and Moral Judgement Interact in the Generation of Cooperative Behaviour. Understanding the psychological forces that underpin human interactions is a necessary step to knowing how to improve those interactions. Comprehending the complex interplay of emotions and moral judgements lying behind decision-making in the social sphere will help explain such things as corruption, risk-taking, domestic violence, and political affiliation. Such knowledge can guide the design of effective social policy, and is vital for a realistic educational strategy. This project will strengthen Australia's excellent reputation in philosophy, bring here leading scholars from diverse fields, build international research networks, and in particular forge an ongoing partnership between the ANU and the California Institute of Technology.Read moreRead less
A genomic and phenomic investigation of a mitochondrial glutathione transferase. The aim of this study is to understand of the genomics, structure and function of glutathione transferase Kappa (GSTK), a novel GST found in mitochondria. The investigations will achieve several outcomes. (1)an understanding of the organisation of GSTK gene(s) in humans and mice; (2) determination of the role of GSTK in mitochondria, by investigating the phenotype of knockout mice; (3) determination of the crysta ....A genomic and phenomic investigation of a mitochondrial glutathione transferase. The aim of this study is to understand of the genomics, structure and function of glutathione transferase Kappa (GSTK), a novel GST found in mitochondria. The investigations will achieve several outcomes. (1)an understanding of the organisation of GSTK gene(s) in humans and mice; (2) determination of the role of GSTK in mitochondria, by investigating the phenotype of knockout mice; (3) determination of the crystal structure of human GSTK; (4) An understanding of GSTK's substrate specificity, reaction kinetics and structure/function relationships. Since GSTK is confined to mitochondria, and may not be related to other GSTs, we may also identify novel functionsRead moreRead less