Analysis And Development Of Medicinal Herbs For The Prevention And Management Of Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$358,500.00
Summary
Although medicinal herbs are widely used in the community for the prevention and management of cardiovascular disease, to date no systemic, effective methods are available to assess the physiological effects of these substances. This project will employ advanced bio-cellular and molecular technologies to develop (i) screening procedures, (ii) standardised chemical analyses and (iii) bioassays to allow efficient assessment of new herbal pharmaceuticals in relation to possible cardiovascular activ ....Although medicinal herbs are widely used in the community for the prevention and management of cardiovascular disease, to date no systemic, effective methods are available to assess the physiological effects of these substances. This project will employ advanced bio-cellular and molecular technologies to develop (i) screening procedures, (ii) standardised chemical analyses and (iii) bioassays to allow efficient assessment of new herbal pharmaceuticals in relation to possible cardiovascular activities, side effects, purity and quality.Read moreRead less
Development Of Specific Modulators Of Voltage-gated Sodium Channels
Funder
National Health and Medical Research Council
Funding Amount
$384,479.00
Summary
This project will identify novel modulators of voltage-gated sodium (NaV) channels, a type of sodium-conducting integral membrane proteins, which play a central role in neuronal, muscular, and cardiac function. These modulators will be characterized in order to understand how they modify channel function and to aid their development as analgesics for the treatment of chronic pain.