The development of vaccines and better treatments for HIV-AIDS and Hepatitis C are urgent global health priorities. This Program will undertake studies to better understand effective immunity against HIV and hepatitis C, allowing the rational design and testing of novel vaccines and treatments. The Program brings together a team of researchers with skills in basic virology and immunology with those providing expertise in translating findings in the laboratory into human clinical trials.
Imaging The Hepatitis C Virus Life Cycle In Real-time
Funder
National Health and Medical Research Council
Funding Amount
$477,504.00
Summary
Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may unco ....Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may uncover novel therapeutic strategies to combat HCV.Read moreRead less
Pair bonding: is it all in the brain? This project aims to understand the interaction between classic pair bonding neural circuits, parasites, and the immune system in sleepy lizards. Social bonds are a cornerstone of human societies, especially true of the pair bond and this project expects to generate knowledge to help understand why healthy adult pair bonds are the single best predictor of longevity in humans. The expected outcomes of this project are to reveal the mechanistic basis of pair b ....Pair bonding: is it all in the brain? This project aims to understand the interaction between classic pair bonding neural circuits, parasites, and the immune system in sleepy lizards. Social bonds are a cornerstone of human societies, especially true of the pair bond and this project expects to generate knowledge to help understand why healthy adult pair bonds are the single best predictor of longevity in humans. The expected outcomes of this project are to reveal the mechanistic basis of pair bonding by identifying the brain regions, cell types and neurochemicals that promote pair bonding behaviour — for the first time in a wild animal. This project should provide significant benefits by increasing our knowledge of how pair bonds promote wellness.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102821
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Molecular genetic adaptive processes in natural co-evolution between rabbits and the rabbit haemorrhagic disease virus. This project will use extensive sampling and long-term field data to reveal ongoing co-evolutionary mechanisms behind the increasing resistance of pest Australian wild rabbits against a viral pathogen. The results will increase the understanding of evolutionary mechanisms in nature and will provide basic information for biological pest control of rabbits.
The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
How we remember and misremember traumatic experiences. The project addresses a significant and important problem: the role of memory distortion in Post Traumatic Stress Disorder (PTSD), a global disorder with significant personal, societal and economic costs. The aim of this project is to empirically investigate the extent, causes and triggering conditions of errors in memory for traumatic experiences; particularly exaggeration of these memories, which has been linked to poor psychological adjus ....How we remember and misremember traumatic experiences. The project addresses a significant and important problem: the role of memory distortion in Post Traumatic Stress Disorder (PTSD), a global disorder with significant personal, societal and economic costs. The aim of this project is to empirically investigate the extent, causes and triggering conditions of errors in memory for traumatic experiences; particularly exaggeration of these memories, which has been linked to poor psychological adjustment. Understanding how people exposed to trauma remember, and misremember, aspects of their experiences in ways that influence their recovery is both theoretically and practically important. Indeed, it will help us refine theory and identify possible points of intervention for PTSD sufferers.Read moreRead less
Coevolution of sundew bugs and sundews. This project aims to conduct a study of insect-plant interactions to determine if insects and plants coevolve or if they diversify by other evolutionary processes. Insect-plant coevolution is a hotly contested field in evolutionary biology. In Australia, a remarkable interaction exists between carnivorous plants and a group of bugs that steal the plant’s prey. This system offers a great opportunity to test competing coevolutionary theories through a combin ....Coevolution of sundew bugs and sundews. This project aims to conduct a study of insect-plant interactions to determine if insects and plants coevolve or if they diversify by other evolutionary processes. Insect-plant coevolution is a hotly contested field in evolutionary biology. In Australia, a remarkable interaction exists between carnivorous plants and a group of bugs that steal the plant’s prey. This system offers a great opportunity to test competing coevolutionary theories through a combination of historical and ecological approaches. The project expects to showcase the evolution and uniqueness of Australia’s native biota.Read moreRead less
Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the h ....Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the health system. The data collected in this project will assist in developing health services to meet these needs.Read moreRead less
Can parasites cause host population divergence? . Parasites have been proposed to be drivers of population divergence, and ultimately speciation, yet the dynamics of this process are not well understood. This project will utilise new genomic techniques, novel hybrid zone analyses, and data on mate choice, to investigate the hypothesis that parasites drive population divergence through an interaction with immune response genes in the sleepy lizard Tiliqua rugosa. This species provides an unpreced ....Can parasites cause host population divergence? . Parasites have been proposed to be drivers of population divergence, and ultimately speciation, yet the dynamics of this process are not well understood. This project will utilise new genomic techniques, novel hybrid zone analyses, and data on mate choice, to investigate the hypothesis that parasites drive population divergence through an interaction with immune response genes in the sleepy lizard Tiliqua rugosa. This species provides an unprecedented system, backed by 37 years of long term host-parasite and behavioural data, and recent genetic analyses. This project intends to produce significant data to allow an examination of the early stages of host-parasite evolution in action, providing novel insights into the speciation process. Read moreRead less
What drives parasite spread through social networks: lessons from lizards. Australia's biodiversity is continually threatened by new epidemics of local and foreign diseases and parasites. This project will enhance our understanding of how these diseases spread, allowing more effective controls to be developed to protect wildlife species, animal populations and, ultimately, Australian ecosystems.