What is killing the honeybees? The role of RNA viruses. This project aims to determine if the Varroa mite, the most important parasite of honeybees, selects for virulent strains of RNA viruses. Before Varroa’s inevitable arrival in Australia, this project will disentangle the effect of Varroa and the bees’ immune system on the evolution of virulence of bee viruses. Australia’s honeybees are Varroa-naïve and don’t carry virulent viruses. There is a known association between Varroa and colonies dy ....What is killing the honeybees? The role of RNA viruses. This project aims to determine if the Varroa mite, the most important parasite of honeybees, selects for virulent strains of RNA viruses. Before Varroa’s inevitable arrival in Australia, this project will disentangle the effect of Varroa and the bees’ immune system on the evolution of virulence of bee viruses. Australia’s honeybees are Varroa-naïve and don’t carry virulent viruses. There is a known association between Varroa and colonies dying from viruses; however, it is not known what is cause and effect. This project will clarify Varroa’s exact role in the evolution of virulence in RNA viruses. The intended outcome is increased knowledge allowing the design of an effective treatment to prevent the death of honeybee colonies.Read moreRead less
Nucleomodulin effectors of the environmental pathogen Legionella. This project aims to examine the evolution of Legionella as an intracellular organism and the mechanisms by which the bacteria evade environmental predation by amoebae. Aside from the advancement of knowledge, expected outcomes of this project include a greater understanding of amoebae. This will provide significant benefits, and this knowledge may be used to develop inhibitors of amoebae growth.
Integrating nutritional immunology. What an organism eats affects both its susceptibility to disease and the community of beneficial microorganisms living within its gut. This project will study how nutrition, immunity and the flora of the gut interact, and whether hosts are able to select a diet that optimises their immune response and gut flora in the face of disease challenges.
Evolving with sexually transmitted infections. This project aims to understand how sexually transmitted infections (STIs) affect the evolution of host mating systems. STIs threaten the health of most sexually-reproducing organisms. In evolutionary terms, their mode of transmission imposes distinct selection patterns on hosts. This project will use an Australian beetle and its sexually transmitted mite to investigate how STIs lead to evolutionary changes in host mating behaviour and explore the g ....Evolving with sexually transmitted infections. This project aims to understand how sexually transmitted infections (STIs) affect the evolution of host mating systems. STIs threaten the health of most sexually-reproducing organisms. In evolutionary terms, their mode of transmission imposes distinct selection patterns on hosts. This project will use an Australian beetle and its sexually transmitted mite to investigate how STIs lead to evolutionary changes in host mating behaviour and explore the genetic basis for STI resistance. This project is expected to affect the evolution of host mating biology and lead to sex-specific optimal levels of disease resistance, which can influence disease dynamics and host-disease coevolution.Read moreRead less
Linking sex-specific adaptation to the evolution of infectious disease. This project aims to examine how differences in the response of males and females to pathogen attack can influence the evolution of infectious disease. This project expects to generate new knowledge in the area of host-pathogen co-evolution, by integrating approaches from the fields of evolutionary genetics, sexual selection, and epidemiology. Expected outcomes include an enhanced capacity to build interdisciplinary collabor ....Linking sex-specific adaptation to the evolution of infectious disease. This project aims to examine how differences in the response of males and females to pathogen attack can influence the evolution of infectious disease. This project expects to generate new knowledge in the area of host-pathogen co-evolution, by integrating approaches from the fields of evolutionary genetics, sexual selection, and epidemiology. Expected outcomes include an enhanced capacity to build interdisciplinary collaborations and development of theory that predicts infection dynamics in any species with separate sexes. This is expected to provide significant benefits, such as improving our knowledge of why the sexes differ and potentially providing new avenues for understanding disease outbreaks and preventing population declines or extinctions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100327
Funder
Australian Research Council
Funding Amount
$378,000.00
Summary
Does sex matter? The impact of sex differences on pathogen evolution. Males and females experience the burden of infection differently. Males are typically thought of as the 'sicker sex', favouring investment in costly sexual displays, at the expense of immune function. But what does this mean for the pathogen? Each sex presents a unique set of challenges that an invading organism must overcome; yet the impact of these differences on pathogen evolution has been surprisingly overlooked. This proj ....Does sex matter? The impact of sex differences on pathogen evolution. Males and females experience the burden of infection differently. Males are typically thought of as the 'sicker sex', favouring investment in costly sexual displays, at the expense of immune function. But what does this mean for the pathogen? Each sex presents a unique set of challenges that an invading organism must overcome; yet the impact of these differences on pathogen evolution has been surprisingly overlooked. This project aims to unravel how sex-specific challenges influence the outcome of pathogen evolution. This work will show how infection in males or females can alter the evolutionary potential of disease, and will ask whether same-sex populations could ever lead to the evolution of new pathogen strains and virulence genes.Read moreRead less
Revealing the determinants of viral emergence and evolution in fish. Viral diseases pose an ongoing threat to Australian aquaculture. The devastating impact of emerging viruses makes it imperative to understand the factors that allow them to evolve and infect new hosts. We will address these key issues by revealing the diversity, abundance and evolution of viruses in fish sampled along the Australian east coast. The data generated will reveal the untapped biodiversity of fish viruses, the freque ....Revealing the determinants of viral emergence and evolution in fish. Viral diseases pose an ongoing threat to Australian aquaculture. The devastating impact of emerging viruses makes it imperative to understand the factors that allow them to evolve and infect new hosts. We will address these key issues by revealing the diversity, abundance and evolution of viruses in fish sampled along the Australian east coast. The data generated will reveal the untapped biodiversity of fish viruses, the frequency which they jump species boundaries and the determinants of this process, and how they are impacted by host ecology, including whether fish viruses follow a latitudinal gradient in diversity. The data generated will transform our understanding of fish viruses and identify those most likely to impact aquaculture.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102821
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Molecular genetic adaptive processes in natural co-evolution between rabbits and the rabbit haemorrhagic disease virus. This project will use extensive sampling and long-term field data to reveal ongoing co-evolutionary mechanisms behind the increasing resistance of pest Australian wild rabbits against a viral pathogen. The results will increase the understanding of evolutionary mechanisms in nature and will provide basic information for biological pest control of rabbits.
Discovery Early Career Researcher Award - Grant ID: DE130100470
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Understanding mechanisms and functions of evolutionary divergence in innate immune genes. Microorganisms constantly challenge the immune systems of all multi-cellular organisms, and host immune genes must be able to co-evolve with microbes in order for a species to propagate. This project will investigate how host immune genes in a species evolve to enable that species to continue.
Altering host-parasite interactions through wildlife conservation strategies. Disease outbreaks are heightened in endangered animals but strategies used to conserve these species often increase risk of disease; nowhere is this more critical than in species recovery programs. The project will study disease in a recovery program to improve conservation practice and protect Australia's wildlife, ensuring our ecosystems are sustained.