Understanding Virulence In Staphylococcus Aureus And Impacts On Host Response
Funder
National Health and Medical Research Council
Funding Amount
$574,890.00
Summary
Golden Staph remains an important cause of serious infections in Australian patients. New strategies to combat this disease require a better understanding of how Golden Staph causes disease and escapes the natural human response to infection. This study will provide new insights into how Golden Staph causes disease, and provide a platform for developing new strategies to prevent and treat Golden Staph infections.
This program will investigate the strategies used by pathogenic bacteria to cause human diseases. The research will focus on how bacteria initiate infections, how they invade, cause cell and tissue damage and respond to their human host. It will also examine how the host’s innate immune system interacts with these bacteria. The results will provide new insights into host-pathogen interactions and reveal new targets for the development of novel antibacterial drugs and vaccines.
Function And Inhibition Of Plasmepsin V In Targeting Malaria Virulence Proteins Into Human Erythrocytes
Funder
National Health and Medical Research Council
Funding Amount
$407,845.00
Summary
Malaria parasites dramatically renovate infected erythrocytes to survive and evade the host immune system by delivering hundreds of exported parasite proteins into the cell. The parasite protease Plasmepsin V is essential for protein export. We aim to develop potent inhibitors of this protease in the hope of blocking its function and killing the parasite. We also aim to discover the components of the trafficking pathway after cleavage by Plasmepsin V that sorts virulence proteins to the host cel ....Malaria parasites dramatically renovate infected erythrocytes to survive and evade the host immune system by delivering hundreds of exported parasite proteins into the cell. The parasite protease Plasmepsin V is essential for protein export. We aim to develop potent inhibitors of this protease in the hope of blocking its function and killing the parasite. We also aim to discover the components of the trafficking pathway after cleavage by Plasmepsin V that sorts virulence proteins to the host cell.Read moreRead less
Evolution And Function Of A Novel Lateral Flagellar Locus, Flag-2, In Pathogenic Escherichia Coli
Funder
National Health and Medical Research Council
Funding Amount
$465,158.00
Summary
This project will study how the bacteria that cause infant diarrhoea colonize the intestine and induce disease. We have identified a novel genetic region that allows E. coli to survive and persist in the intestine. Similar genes are also present in closely related organisms. This project will help us to undestand how new diseases evolve and emerge and may lead to the development of new vaccines to protect against infant diarrhoea.
ROLE OF RIP KINASES & IAPs IN MUCOSAL IMMUNE DEFENCE
Funder
National Health and Medical Research Council
Funding Amount
$631,168.00
Summary
Pathogenic bacteria are master manipulators of the inflammatory signalling pathways designed to thwart them. Understanding how they do this will allow us to develop drugs that limit their ability to infect. We have shown that pathogenic bacteria inject a protein called EspL into human cells to promote the destruction of a family of human proteins, called RIP Kinases (RIPK), that co-ordinate the inflammatory response and aim now to discover how EspL causes RIPK degradation and thereby promotes in ....Pathogenic bacteria are master manipulators of the inflammatory signalling pathways designed to thwart them. Understanding how they do this will allow us to develop drugs that limit their ability to infect. We have shown that pathogenic bacteria inject a protein called EspL into human cells to promote the destruction of a family of human proteins, called RIP Kinases (RIPK), that co-ordinate the inflammatory response and aim now to discover how EspL causes RIPK degradation and thereby promotes infection.Read moreRead less
Biology and evolution of intracellular parasitism. This project will investigate the development of intracellular parasitism in environmental amoebae. The outcomes of this work will help to understand the mechanisms by which bacteria have evolved to survive inside cells and in some cases cause disease.
Discovery Early Career Researcher Award - Grant ID: DE190101151
Funder
Australian Research Council
Funding Amount
$398,000.00
Summary
Designing augmented eating interfaces to promote mindful eating. This project aims to develop and test novel augmented eating interfaces in order to address the contradiction between the concept of mindful eating (no distractions) and the reality of screen cultures (eating with screens). Eating while watching screens can be problematic because it can cause overeating, which can manifest into bigger health concerns such as obesity and heart disease. This project expects to generate new knowledge ....Designing augmented eating interfaces to promote mindful eating. This project aims to develop and test novel augmented eating interfaces in order to address the contradiction between the concept of mindful eating (no distractions) and the reality of screen cultures (eating with screens). Eating while watching screens can be problematic because it can cause overeating, which can manifest into bigger health concerns such as obesity and heart disease. This project expects to generate new knowledge in the field of human-food interaction. It presents two new augmented eating systems and a socio-technological study of these systems in use within Australian households. The expected outcomes include a framework on how to design interactive systems that encourage mindful eating without compromising the pleasures of screen-based media and the eating experience, and a greater theoretical understanding of how to support mindful eating in everyday practice.Read moreRead less
Co-designing Innovations in Digital Storytelling with Older Adults. This project aims to investigate how emerging technologies can be leveraged to provide innovative ways for older adults to create and share their life stories to foster social wellbeing. Later life can be a time of considerable change, leaving people feeling disconnected from the people, places, and life events that are important to them. Autobiographical storytelling can help create links with one's past, but little is known ab ....Co-designing Innovations in Digital Storytelling with Older Adults. This project aims to investigate how emerging technologies can be leveraged to provide innovative ways for older adults to create and share their life stories to foster social wellbeing. Later life can be a time of considerable change, leaving people feeling disconnected from the people, places, and life events that are important to them. Autobiographical storytelling can help create links with one's past, but little is known about how technologies such as digital games and virtual reality can be used to enable older adults to share stories about their lives in a way that supports ongoing social interactions. This project is expected to co-design new forms of digital storytelling to improve social wellbeing of older adults. Read moreRead less
Designing distanced intergenerational interaction with tangible technology. Older people and their young relatives/grandchildren who are geographically distanced cannot currently experience closeness in tangible ways, which are the natural ways they would play and build relationships in “real” life. Enabling this connection would have positive impacts for both groups, and two types of technologies – Mixed Reality and Tangibles - can be explored to allow us to understand how to do this. We will d ....Designing distanced intergenerational interaction with tangible technology. Older people and their young relatives/grandchildren who are geographically distanced cannot currently experience closeness in tangible ways, which are the natural ways they would play and build relationships in “real” life. Enabling this connection would have positive impacts for both groups, and two types of technologies – Mixed Reality and Tangibles - can be explored to allow us to understand how to do this. We will develop approaches to distanced tangible intergenerational interaction which are designed specifically to increase intergenerational closeness and to be innovative and subtle so that they fit seamlessly into the lives of older people and young children.Read moreRead less
(Re)Designing Digital Justice. This project aims to address the challenge of (re)designing novel online court systems by introducing a human-centred design process to the legal process. This project will generate fundamental new knowledge in respect of how to effectively design an inclusive justice system, bridging the gap between the legal system and human-computer interaction. Expected outcomes include how to use technology to implement a more just, efficient, and fair legal system, which is a ....(Re)Designing Digital Justice. This project aims to address the challenge of (re)designing novel online court systems by introducing a human-centred design process to the legal process. This project will generate fundamental new knowledge in respect of how to effectively design an inclusive justice system, bridging the gap between the legal system and human-computer interaction. Expected outcomes include how to use technology to implement a more just, efficient, and fair legal system, which is accessible to all Australians. This should provide significant benefits for both Australian society and the legal system.Read moreRead less