What is killing the honeybees? The role of RNA viruses. This project aims to determine if the Varroa mite, the most important parasite of honeybees, selects for virulent strains of RNA viruses. Before Varroa’s inevitable arrival in Australia, this project will disentangle the effect of Varroa and the bees’ immune system on the evolution of virulence of bee viruses. Australia’s honeybees are Varroa-naïve and don’t carry virulent viruses. There is a known association between Varroa and colonies dy ....What is killing the honeybees? The role of RNA viruses. This project aims to determine if the Varroa mite, the most important parasite of honeybees, selects for virulent strains of RNA viruses. Before Varroa’s inevitable arrival in Australia, this project will disentangle the effect of Varroa and the bees’ immune system on the evolution of virulence of bee viruses. Australia’s honeybees are Varroa-naïve and don’t carry virulent viruses. There is a known association between Varroa and colonies dying from viruses; however, it is not known what is cause and effect. This project will clarify Varroa’s exact role in the evolution of virulence in RNA viruses. The intended outcome is increased knowledge allowing the design of an effective treatment to prevent the death of honeybee colonies.Read moreRead less
Scalable Visual Analytics for Uncertain Dynamic Networks. Technological advances have provided a data deluge over the past few years, and have led to many large uncertain and dynamic network models. This includes terrorist networks, marketing networks, facebook networks, various biological networks, and software engineering structures. Human understanding of such networks is difficult. This project aims to provide new methods for visual analysis of large uncertain dynamic networks such as these. ....Scalable Visual Analytics for Uncertain Dynamic Networks. Technological advances have provided a data deluge over the past few years, and have led to many large uncertain and dynamic network models. This includes terrorist networks, marketing networks, facebook networks, various biological networks, and software engineering structures. Human understanding of such networks is difficult. This project aims to provide new methods for visual analysis of large uncertain dynamic networks such as these. The algorithms developed in the project will help security analysts to monitor illegal behaviour such as money laundering and terrorist activities, help biologists understand key biological systems, and help engineers to understand large software systems.Read moreRead less
Integrating nutritional immunology. What an organism eats affects both its susceptibility to disease and the community of beneficial microorganisms living within its gut. This project will study how nutrition, immunity and the flora of the gut interact, and whether hosts are able to select a diet that optimises their immune response and gut flora in the face of disease challenges.
Evolutionary history and impact of adeno-associated viruses in Australia. Recently accrued evidence identifies Australia as an ideal closed-model system in which to elucidate the evolutionary history of a group of non-pathogenic viruses, known as adeno-associated viruses (AAVs). This project aims to trace back the evolutionary history of AAVs for tens of millions of years via molecular fossil imprints left behind by ancient viral invasions of Australian marsupial genomes. Concurrently, the poten ....Evolutionary history and impact of adeno-associated viruses in Australia. Recently accrued evidence identifies Australia as an ideal closed-model system in which to elucidate the evolutionary history of a group of non-pathogenic viruses, known as adeno-associated viruses (AAVs). This project aims to trace back the evolutionary history of AAVs for tens of millions of years via molecular fossil imprints left behind by ancient viral invasions of Australian marsupial genomes. Concurrently, the potential impact that these viral invasions had on the evolutionary development of their ancestral hosts will be investigated. This could facilitate previously unattainable insights into both AAV and marsupial evolution, with broader implications relevant to the advancement of the fields of virology and mammalian evolution.Read moreRead less
Revealing the determinants of viral emergence and evolution in fish. Viral diseases pose an ongoing threat to Australian aquaculture. The devastating impact of emerging viruses makes it imperative to understand the factors that allow them to evolve and infect new hosts. We will address these key issues by revealing the diversity, abundance and evolution of viruses in fish sampled along the Australian east coast. The data generated will reveal the untapped biodiversity of fish viruses, the freque ....Revealing the determinants of viral emergence and evolution in fish. Viral diseases pose an ongoing threat to Australian aquaculture. The devastating impact of emerging viruses makes it imperative to understand the factors that allow them to evolve and infect new hosts. We will address these key issues by revealing the diversity, abundance and evolution of viruses in fish sampled along the Australian east coast. The data generated will reveal the untapped biodiversity of fish viruses, the frequency which they jump species boundaries and the determinants of this process, and how they are impacted by host ecology, including whether fish viruses follow a latitudinal gradient in diversity. The data generated will transform our understanding of fish viruses and identify those most likely to impact aquaculture.Read moreRead less
Integrating human operators into large-scale sensor networks. Information awareness is critical in many applications of national importance: from bush fire fighting and defence to transportation and health care. These applications involve tasks in which timely delivery and fusion of heterogeneous information streams is of critical importance. They can all benefit from the use of robotic and embedded sensor networks considered in this project. Human operators, acting as users or supervisors, will ....Integrating human operators into large-scale sensor networks. Information awareness is critical in many applications of national importance: from bush fire fighting and defence to transportation and health care. These applications involve tasks in which timely delivery and fusion of heterogeneous information streams is of critical importance. They can all benefit from the use of robotic and embedded sensor networks considered in this project. Human operators, acting as users or supervisors, will remain at the centre of these systems. The technology and algorithms developed in this project will efficiently structure information exchange between humans and sensor networks. Establishing Australian leadership in this fast-evolving high-technology field will spur growth and job creation.Read moreRead less
Gesture-controlled interaction to enrich information access. This project is a study of gestural computing (enabled by sensors such as pressure mats, infra-red sensors and video tracking) which aims to move away from desk-bound, restrictive computing environments and towards computing that is more integral to the building structure and space itself. Linking gesture controllers and information sonification delivers a unique bridge between data and human interaction. Enriching the capacity to acce ....Gesture-controlled interaction to enrich information access. This project is a study of gestural computing (enabled by sensors such as pressure mats, infra-red sensors and video tracking) which aims to move away from desk-bound, restrictive computing environments and towards computing that is more integral to the building structure and space itself. Linking gesture controllers and information sonification delivers a unique bridge between data and human interaction. Enriching the capacity to access information in dense workplace environments is central to improved efficiency across the Australian workforce. Greater accuracy and enhanced techniques for controlling information in visually-overloaded work environments contribute to Australia's competitive leadership in a global marketplace.Read moreRead less
Situated Design Computing: A New Paradigm to Support Design Using Situated Reasoning. A country like Australia with its twin disadvantages of distance from its large markets and small population as its own market has to found its goals in its wealth production on its ability to compete at the high value-adding loci of the economy. Design is a precursor to superior products and is one of the nation's high value-adding wealth generating activities. This project aims to lay the foundations for a ....Situated Design Computing: A New Paradigm to Support Design Using Situated Reasoning. A country like Australia with its twin disadvantages of distance from its large markets and small population as its own market has to found its goals in its wealth production on its ability to compete at the high value-adding loci of the economy. Design is a precursor to superior products and is one of the nation's high value-adding wealth generating activities. This project aims to lay the foundations for a new class of design support tools that have the capacity to be used at a variety of stages in the design process including those stages where major decisions are being taken. This will have the potential to improve the efficacy and the efficiency of Australian design and hence make it more globally competitive.Read moreRead less
One Day, We'll All Invest This Way! Regulating Online Investment. This project will provide policy recommendations to promote national research priority 3: particularly goals 4 & 5. It will do this by using good regulation to increase the safety of online investing services. It will bring to Australia international expertise not available here, crucial to good regulation of online investing. If investors trust this mostly beneficial technology it will further Australians' prosperity through in ....One Day, We'll All Invest This Way! Regulating Online Investment. This project will provide policy recommendations to promote national research priority 3: particularly goals 4 & 5. It will do this by using good regulation to increase the safety of online investing services. It will bring to Australia international expertise not available here, crucial to good regulation of online investing. If investors trust this mostly beneficial technology it will further Australians' prosperity through investment e.g. for retirement. Competitive advantage through good regulation will bring overseas investors to Australia through the Internet. It will consolidate its role as a financial centre. With 51% of adults owning shares, this research could save Australians more than $1.6 billion per annum! Read moreRead less
Cracking the code of snails to elucidate parasite disease transmission. In Australia, a disease caused by liver flukes causes major economic losses to livestock production. The role of Australian pond snails as intermediate hosts for this parasite is poorly understood. This project aims to explore the phylogeography, biology and genomics of these snails. It expects to create novel molecular resources for important snail species and verify their roles as key vectors of flatworm parasites. The cur ....Cracking the code of snails to elucidate parasite disease transmission. In Australia, a disease caused by liver flukes causes major economic losses to livestock production. The role of Australian pond snails as intermediate hosts for this parasite is poorly understood. This project aims to explore the phylogeography, biology and genomics of these snails. It expects to create novel molecular resources for important snail species and verify their roles as key vectors of flatworm parasites. The curation of genomic and transcriptomic data sets, and elucidation of snail–parasite interactions will underpin the development of environmental diagnostic tests and deliver a new generation of intervention strategies to reduce the burden of liver fluke disease through the control of their snail intermediate hosts.Read moreRead less