This project will test the proposal that rising follicle-stimulating hormone (FSH) levels in ageing females directly accelerate reproductive failure and bone loss , major public health issues due to delayed childbearing and our rising ageing population. We have developed a unique mouse model with elevated FSH levels that cause premature female infertility. We will now use this model to determine the direct effects of high FSH upon ovarian and uterine function, as well as bone loss with age.
Adolescent Rural Cohort Study Hormones, Health, Education, Environments And Relationships
Funder
National Health and Medical Research Council
Funding Amount
$1,016,983.00
Summary
Adolescence is a time of major physical, emotional and social change, often characterised by risk taking and experimentation. Behaviours and decisions taken at this time of life will shape future health. This rural cohort study will for the first time will study the influence of pubertal hormones on behaviours, mental and physical health and general well being in adolescents.
Immunological Changes During Pregnancy And The Impact On Viral Hepatitis Infection
Funder
National Health and Medical Research Council
Funding Amount
$353,355.00
Summary
Hepatitis B virus (HBV) can cause long term health problems particularly affecting the liver and can be passed from mother to baby. Despite the availability of a HBV vaccine babies can still become infected. During pregnancy there are changes in a woman’s immune system which may impact on HBV infection and make transmission to the baby more likely. This research aims to explore the changes in a woman’s immune system and the impact this has on risks for hepatitis and transmission to the baby.