New High-risk Variants For Colorectal Cancer: The Post-GWAS Era
Funder
National Health and Medical Research Council
Funding Amount
$710,105.00
Summary
Our aim is to discover new genes that greatly increase bowel cancer risk. If we can identify these carriers we may be able to prevent them getting cancer. By studying DNA related to bowel cancer, using a novel family design, we will identify families most likely to carry the new genes. We will focus genetic testing, using new techniques, to look for mutations in these prioritised families. Identified mutations will be tested in a 3,500 bowel cancer cases to see how important they are.
New multi-scale seed dispersal models for improved regional weed management. This project will exploit recent advances in ecological and atmospheric modelling with the aim to build improved models of seed dispersal across landscapes to anticipate weed spread. Damaging invasive plants are rapidly transforming landscapes and altering ecosystem function worldwide. The speed and direction of weed spread determines the success or failure of costly containment and control actions, however we lack the ....New multi-scale seed dispersal models for improved regional weed management. This project will exploit recent advances in ecological and atmospheric modelling with the aim to build improved models of seed dispersal across landscapes to anticipate weed spread. Damaging invasive plants are rapidly transforming landscapes and altering ecosystem function worldwide. The speed and direction of weed spread determines the success or failure of costly containment and control actions, however we lack the ability to adequately predict spread. New models that combine micrometeorological measurements, within-canopy turbulence and topographic variation in wind flows will be designed to better predict where dispersal will occur. In this project, these improved predictions are planned to be combined with decision models to direct the management of invasive species across entire landscapes.Read moreRead less
Understanding snow gum dieback for effective and integrated management. The project leverages recent research and infrastructure investments and our determined and collaborative team as it aims to: 1) assess the future geography of snow gum dieback in the high country and identify priority locations for pro-active management, 2) quantify the impact of snow gums on high country water and carbon budgets and thus the socio- economic and biodiversity values, and 3) determine options for mitigation. ....Understanding snow gum dieback for effective and integrated management. The project leverages recent research and infrastructure investments and our determined and collaborative team as it aims to: 1) assess the future geography of snow gum dieback in the high country and identify priority locations for pro-active management, 2) quantify the impact of snow gums on high country water and carbon budgets and thus the socio- economic and biodiversity values, and 3) determine options for mitigation. Dieback of our iconic snow gum forests is diminishing the ecological, hydrological and cultural values of the Australian Alps and will impact state and national water-supply and power-generation systems. Our research will inform Alps-wide management efforts designed for long-term success.Read moreRead less
Extracting subtle hints for new phenomena at the Large Hadron Collider. This project aims to investigate the detailed nature of the Higgs theory which underpins the mass of elementary particles. The project aims to increase the understanding of particle interactions in the context of precise measurements of the properties of the Higgs boson that will come out of the experimental program at the large hadron collider. Expected outcomes include the development and application of methods to address ....Extracting subtle hints for new phenomena at the Large Hadron Collider. This project aims to investigate the detailed nature of the Higgs theory which underpins the mass of elementary particles. The project aims to increase the understanding of particle interactions in the context of precise measurements of the properties of the Higgs boson that will come out of the experimental program at the large hadron collider. Expected outcomes include the development and application of methods to address existing gaps in the framework that confronts theory and experiment and to efficiently explore its high dimensionality. The benefits of conducting this research in Australia include the development of intellectual culture and the training of early-career researchers as flexible problem solvers in academia or beyond. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100867
Funder
Australian Research Council
Funding Amount
$367,518.00
Summary
Bridging the accuracy gap: High-precision parton showers for colliders. This project aims at improving the accuracy of parton showers, which are an essential ingredient used in the simulation of high-energy particle collisions. Parton showers generate the large set of particles produced in a collision, in an approximation of the radiation pattern of Quantum Chromodynamics. The low precision of this approximation translates into large uncertainties in critical measurements performed at particle c ....Bridging the accuracy gap: High-precision parton showers for colliders. This project aims at improving the accuracy of parton showers, which are an essential ingredient used in the simulation of high-energy particle collisions. Parton showers generate the large set of particles produced in a collision, in an approximation of the radiation pattern of Quantum Chromodynamics. The low precision of this approximation translates into large uncertainties in critical measurements performed at particle colliders. This project will study novel ways of enhancing the precision of parton showers, and determine accurate estimates of associated uncertainties across all processes under investigation at the Large Hadron Collider. It will be of exceptional importance for the latter's high-precision, high-luminosity program.Read moreRead less
Beautiful strings. This project aims to carry out several key experimental measurements, in tandem with substantial theoretical work, to improve the understanding and physical modelling of processes involving b quarks, also called beauty quarks, which are of intense current interest for experiments across the globe. Key theoretical innovations include novel treatments of electromagnetic corrections, novel theoretical formulations of the dominant physical paradigm of string fragmentation, and opt ....Beautiful strings. This project aims to carry out several key experimental measurements, in tandem with substantial theoretical work, to improve the understanding and physical modelling of processes involving b quarks, also called beauty quarks, which are of intense current interest for experiments across the globe. Key theoretical innovations include novel treatments of electromagnetic corrections, novel theoretical formulations of the dominant physical paradigm of string fragmentation, and optimisations of key associated algorithms to enable new applications of broad relevance. Experimental measurements will be carried out to validate the new theoretical developments and use them to minimise theoretical uncertainties.Read moreRead less
Building resilient alpine environments with less snow. In this project, we aim to build resilience into alpine National Parks and Alpine Resorts to counter the effects of ongoing declines in snow. Alpine environments depend on snow to regulate water flows, insulate vegetation, control soil erosion and promote proper ecosystem functioning. How these processes will operate in a snow-free future is unknown. We will determine how and where snow characteristics drive soil water availability for plant ....Building resilient alpine environments with less snow. In this project, we aim to build resilience into alpine National Parks and Alpine Resorts to counter the effects of ongoing declines in snow. Alpine environments depend on snow to regulate water flows, insulate vegetation, control soil erosion and promote proper ecosystem functioning. How these processes will operate in a snow-free future is unknown. We will determine how and where snow characteristics drive soil water availability for plants and which plant species have the best adaptation and regeneration potential under extreme conditions such as heat, frost and drought. Benefits of the project include innovative land management and rehabilitation solutions, to safeguard Australia's alpine areas under changing environmental conditions.Read moreRead less
Modelling Of Clinic And Ambulatory Blood Pressure On Cardiovascular Risk And Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$133,957.00
Summary
Whilst ambulatory blood pressure monitoring data has been shown to be a good predictor of cardiovascular events, there remains controversy as to its utility in clinical practice. This project will use data from existing population and clinical cohort studies to examine the role of ambulatory blood pressure in risk assessment and hypertension management in Australia and around the globe. The findings are likely to have a major impact on clinical guidelines for hypertension management.