This Program Grant has three investigators, Professor Denis Moss, Dr Rajiv Khanna and Dr Scott Burrows, each of whom has collaborated on two previous Program Grants. The group is well known in the area of herpesvirus immunology and have published numerous scientific papers in leading medical journals. This program grant focuses on two human herpesviruses. The first is called Epstein-Barr virus which causes glandular fever and is associated with arange of human cancers. The second virus is human ....This Program Grant has three investigators, Professor Denis Moss, Dr Rajiv Khanna and Dr Scott Burrows, each of whom has collaborated on two previous Program Grants. The group is well known in the area of herpesvirus immunology and have published numerous scientific papers in leading medical journals. This program grant focuses on two human herpesviruses. The first is called Epstein-Barr virus which causes glandular fever and is associated with arange of human cancers. The second virus is human cytomegalovirus which can cause birth defects and problems in transplant patients. In this program we are investigating how the body�s immune system controls these viruses to exploit this information to develop new treatments.Read moreRead less
Immunopathogenesis Of Human And Murine Herpes Simplex Infections
Funder
National Health and Medical Research Council
Funding Amount
$315,000.00
Summary
Herpes Simplex virus causes genital herpes, brain infections, eye infections and if passed by a mother to her infant during delivery can cause a highly damaging and sometimes lethal disease in the newborn. The virus has developed a number of strategies to overcome our immune system. The aim of this grant is to define some of these strategies in human tissue and in mice and in order to reverse them we are also defining the viral proteins which stimulate the critical immune cells . In addition we ....Herpes Simplex virus causes genital herpes, brain infections, eye infections and if passed by a mother to her infant during delivery can cause a highly damaging and sometimes lethal disease in the newborn. The virus has developed a number of strategies to overcome our immune system. The aim of this grant is to define some of these strategies in human tissue and in mice and in order to reverse them we are also defining the viral proteins which stimulate the critical immune cells . In addition we wish to understand the reasons why newborn babies have severe herpes disease compared to adults . What we learn from our experiments will assist us in developing a more effective vaccine against herpes and find new ways to treat this virus in the very young.Read moreRead less