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Post-operative Concurrent Chemo-radiotherapy Versus Post-operative Radiotherapy In High Risk Cutaneous Squamous Cell Carcinoma Of The Head And Neck
Funder
National Health and Medical Research Council
Funding Amount
$252,000.00
Summary
Squamous cell carcinoma of the skin is one of the most common cancers affecting Australians. The majority are readily cured with simple local therapy, such as surgery. However some patients develop advanced disease requiring surgery and post-operative radiotherapy. Despite this, some patients do not achieve cure. This study aims to improve cure rates for these patients by comparing post-operative radiotherapy (control arm) to post-operative chemo-radiotherapy(experimental arm).
Susceptibility Of The Basal Layer Of Human Epidermis To UVA Oxidative Damage Due To Pheomelanin And Suboptimal DNA Repair
Funder
National Health and Medical Research Council
Funding Amount
$559,354.00
Summary
Australia has the highest incidence of skin cancer in the world. It is important to understand how sunlight causes skin cancer and the wavelengths involved in order to devise effective preventative and therapeutic strategies. Our proposal is that the cells in the skin that give rise to the most common forms of skin cancer, squamous cell carcinoma and basal cell carcinoma, are particularly vulnerable to UVA. We aim to study why this is the case and whether this vulnerability can be prevented.