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A Study Of The Relationship Between Vitamin D Status And The Severity And Outcomes Of Chronic Non-cholestatic Liver Disease
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
Vitamin D deficiency is associated with common and severe conditions such as cancer, cardiovascular disease, autoimmune disease and diabetes. Recent studies suggest that vitamin D deficiency also worsens the severity and prognosis of chronic liver disease and that vitamin D replacement may improve outcomes. This research will further investigate the relationship of vitamin D deficiency to liver disease caused by the common conditions hepatitis B and C and non-alcoholic fatty liver disease and th ....Vitamin D deficiency is associated with common and severe conditions such as cancer, cardiovascular disease, autoimmune disease and diabetes. Recent studies suggest that vitamin D deficiency also worsens the severity and prognosis of chronic liver disease and that vitamin D replacement may improve outcomes. This research will further investigate the relationship of vitamin D deficiency to liver disease caused by the common conditions hepatitis B and C and non-alcoholic fatty liver disease and the impact of vitamin D replacement.Read moreRead less
Functional Pharmacogenetics: Analysis Of The Functional Effect Of The IL28B Genotype On Hepatitis C Virus Infection And Treatment Response.
Funder
National Health and Medical Research Council
Funding Amount
$93,843.00
Summary
An estimated 3% of the world�s population is infected with hepatitis C virus (HCV). With low spontaneous clearance rates and often a poor response to treatment many infected individuals will develop long term complications from HCV. Recent studies have identified a genetic variant that is significantly associated with spontaneous viral clearance of HCV and response to treatment for HCV. We propose to further investigate the functional basis for the effect of this human genotype on drug response.
The Effect Of Exercise On Insulin Resistance And The Adipokine Profile In Obese Versus Non Obese Patients With Hepatitis C
Funder
National Health and Medical Research Council
Funding Amount
$100,381.00
Summary
Chronic hepatitis C (CHC) infection and obesity are conditions of increasing prevalence. Untreated, CHC has significant long-term consequences including cirrhosis and liver failure, while obesity reduces the success of antiviral treatment. A tendency to develop diabetes in patients with CHC and obesity also leads to further medical complications. We aim to examine the effects of exercise on obesity and diabetes tendency in patients with CHC.