The Effect Of Follicular Helper T Cells (TFH) On AID Regulation And Selection Of High Affinity Germinal Centre B Cells.
Funder
National Health and Medical Research Council
Funding Amount
$430,964.00
Summary
An integral component of an immune response to foreign pathogens is the production of antibodies by B cells. However, if antibodies react to self-antigens (human molecules rather than bacteria or viruses) they may also cause autoimmune diseases such as lupus. This research project is investigating the mechanisms that control antibody generation by B cells, and how these are dysregulated in autoimmune diseases, such as lupus.
The Differentiation And Function Of T Follicular Helper (TFH) Cells And Their Role In Autoimmunity
Funder
National Health and Medical Research Council
Funding Amount
$143,758.00
Summary
Antibody production is essential for immune responses and regulated by a subset of lymphocytes named T follicular helper (TFH) cells. Consequently, dysregulation of TFH cell function, or expression of TFH cell-associated molecules most likely contributes to the pathogenesis of certain autoimmune or immunodeficient diseases. Knowledge on TFH cells can greatly facilitate the development of new diagnosis and therapy.