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Innate lymphoid cells (ILCs) are found in the lining of the intestine and are part of the intricate crosstalk between the food we eat, good bacteria, epithelial cells and other immune cells. Without ILCs, the body is susceptible to infections through the intestinal tract. I will investigate the signals from nerve cells that control that activity of ILCs during infection to give us insights into pathways that activate ILCs in situations where they are reduced or inactive.
Haemolysins And Haemoglobinases As Anti-hookworm Vaccines.
Funder
National Health and Medical Research Council
Funding Amount
$322,951.00
Summary
To meet its growth and reproductive requirements, hookworms must be able to utilise host haemoglobin located in the red blood cells. To puncture the red blood cell membrane, and break down the exposed haemoglobin into small peptides or single amino acids; the hookworm uses proteases called haemolysins and haemoglobinases. Identifying these proteases and disrupting their function may lead to reduced worm burdens, size and fecundity. Therefore these proteases could be ideal vaccine candidates.
Utilising Transgenesis To Investigate The Role Of Insulin Signaling In Helminthic Infections
Funder
National Health and Medical Research Council
Funding Amount
$316,336.00
Summary
Helminth parasites take an enormous toll on human health, especially in developing countries. Half a billion people suffer debilitating, sometimes fatal illness as a result of these infections. These facts are all the more disturbing when one considers the prospect of nematode parasites developing resistance to the small armamentarium of drugs available for treatment. This proposal will look to further understand the biology of these parasites in order to better comprehend what genes would make ....Helminth parasites take an enormous toll on human health, especially in developing countries. Half a billion people suffer debilitating, sometimes fatal illness as a result of these infections. These facts are all the more disturbing when one considers the prospect of nematode parasites developing resistance to the small armamentarium of drugs available for treatment. This proposal will look to further understand the biology of these parasites in order to better comprehend what genes would make for practical drug or vaccine targets.Read moreRead less
Investigation Of Dendritic Cell Activation And Function In A Murine Model Of Plasmodium And Schistosoma Co-infection
Funder
National Health and Medical Research Council
Funding Amount
$358,938.00
Summary
Malaria is responsible for over 2 million deaths annually, mainly in sub-Saharan Africa. Importantly, around 1 billion people in malaria endemic areas are infected with parasitic worms, thus malaria and worm co-infections frequently occur. This project will investigate how malaria and worm parasites interact to influence the immune response and clinical outcomes of each other in a mouse infection model. This will provide new strategies for the design of effective treatments in co-endemic areas.
Defining Burden And Drivers Of Antibiotic Resistant Bacteria And Healthcare Infections To Plan Cost-effective Interventions
Funder
National Health and Medical Research Council
Funding Amount
$340,891.00
Summary
I am an Infectious Diseases physician and early career researcher with interests in drug resistant infections and hospital infections. The research program will describe the threat of drug-resistant infections by demonstrating which superbugs have the greatest impact and by describing how these bacteria disperse through our health system. The research will evaluate and prioritise strategies to confront these problems.
Characterising And Visualising Cross-presenting Dendritic Cells Following Cutaneous Vaccinia Infection
Funder
National Health and Medical Research Council
Funding Amount
$415,682.00
Summary
Live imaging of cells within lymphoid organs provides a valuable tool allowing insight into how immune responses are initiated. Utilising novel reagents we will visualise and define these events following cutaneous infection with vaccinia virus.
Applied Research In The Prevention And Control Of Infections In The Hospital Setting
Funder
National Health and Medical Research Council
Funding Amount
$174,434.00
Summary
Hospital infections result in increased: (1) length of stay; (2) costs to the healthcare system and individual and (3) morbidity/mortality. Vaccination and hand hygiene are both proven infection control practices. However, compliance rates are still less than ideal. I will study how a new innovative method impacts on uptake of both. Barriers to masks as an infection control strategy will also be examined, as they are one of the few strategies that can be guaranteed to be available in a pandemic.