Investigating A Novel Generic Approach To Anti-Infective Agents
Funder
National Health and Medical Research Council
Funding Amount
$636,833.00
Summary
Alpha helical regions of proteins mediate infection by viruses and bacteria. Short peptides corresponding to these helical segments are unstructured in water. We will (a) test new technology for its generic capacity to stabilize 1-4 turns of alpha helical viral and bacterial peptides, (b) test small molecules for helical structure, and (c) test for antiviral, antibacterial or immunogenicity activity in cell assays. Proof of the technology may benefit many fields of medicine and health prevention ....Alpha helical regions of proteins mediate infection by viruses and bacteria. Short peptides corresponding to these helical segments are unstructured in water. We will (a) test new technology for its generic capacity to stabilize 1-4 turns of alpha helical viral and bacterial peptides, (b) test small molecules for helical structure, and (c) test for antiviral, antibacterial or immunogenicity activity in cell assays. Proof of the technology may benefit many fields of medicine and health prevention.Read moreRead less