Physiological significance of transient receptor potential (TRPC3) ion channels in the cochlea. The project seeks to discover the function of transient receptor potential (TRPC3) ion channels in the cochlea. Recent studies have suggested that these proteins, which are expressed by the sensory and neural cells, are key elements regulating sound transduction and neurotransmission. The new knowledge about the physiological processes underlying hearing that this work will provide, will significantl ....Physiological significance of transient receptor potential (TRPC3) ion channels in the cochlea. The project seeks to discover the function of transient receptor potential (TRPC3) ion channels in the cochlea. Recent studies have suggested that these proteins, which are expressed by the sensory and neural cells, are key elements regulating sound transduction and neurotransmission. The new knowledge about the physiological processes underlying hearing that this work will provide, will significantly benefit national and international translational research that seeks to develop systems for controlling the sensitivity of our senses, developing biosensors, interacting with neural networks and developing neural prostheses. International collaborators in this project have enabled development of new models, technology and research training opportunities.Read moreRead less
Suction pipette measurements of mammalian rod photoreceptor recovery following intense bleaching exposures. The aim of this project is to discover the events and processes that prevent retinal photoreceptors from recovering instantaneously following the cessation of exposure to extremely bright illumination. Recordings will be made from single rod photoreceptors cells isolated from the mammalian retina. The work will uncover the relative roles of the 'photoproducts' created when rhodopsin abso ....Suction pipette measurements of mammalian rod photoreceptor recovery following intense bleaching exposures. The aim of this project is to discover the events and processes that prevent retinal photoreceptors from recovering instantaneously following the cessation of exposure to extremely bright illumination. Recordings will be made from single rod photoreceptors cells isolated from the mammalian retina. The work will uncover the relative roles of the 'photoproducts' created when rhodopsin absorbs light: e.g. intermediates such as metarhodopsin and opsin. The molecular knowledge obtained will help us to understand why it is that the visual system recovers so slowly after the eye has experienced very intense light.Read moreRead less
The effect of multisensory and sensory-motor training on auditory accommodation. Learning to use a hearing aid or cochlear implant requires the brain to make adaptive changes to the new type of sensory information provided to the ears. This project examines what drives this accommodation and how we may accelerate the process and maximise its benefits by training so that listeners are able to make better use of these devices.
A contractile cochlear frame - a possible new mechanism of sound adaptation. It is generally accepted that the rigid frame that harbours sensory structures in the hearing organs of modern higher vertebrates has only a passive supporting role. We have discovered a contractile component in the cartilaginous cochlear frame of the lizard Teratoscincus scincus and demonstrated that the tonus of the contractile tissue can be regulated. We hypothesize a new, previously unknown mechanism of slow mechani ....A contractile cochlear frame - a possible new mechanism of sound adaptation. It is generally accepted that the rigid frame that harbours sensory structures in the hearing organs of modern higher vertebrates has only a passive supporting role. We have discovered a contractile component in the cartilaginous cochlear frame of the lizard Teratoscincus scincus and demonstrated that the tonus of the contractile tissue can be regulated. We hypothesize a new, previously unknown mechanism of slow mechanical adaptation in the vertebrate hearing organ. The aim of the proposed project is to examine this hypothesis in more detail.
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Functional imaging of colour pathways in the living eye. In order to repair or regenerate a diseased eye, we require knowledge of the normal pattern or nerve cell connections, and knowing how biology solves the problem of colour vision can be used to improve the design of artificial vision systems. The adaptive optics machine we will build in this project can be used to image nerve cells, fine blood vessels, and nerve fibre bundles in the normal and diseased eye. This will improve Australia's re ....Functional imaging of colour pathways in the living eye. In order to repair or regenerate a diseased eye, we require knowledge of the normal pattern or nerve cell connections, and knowing how biology solves the problem of colour vision can be used to improve the design of artificial vision systems. The adaptive optics machine we will build in this project can be used to image nerve cells, fine blood vessels, and nerve fibre bundles in the normal and diseased eye. This will improve Australia's research and development capacity in this new area of medical diagnostics. Our machine will be made available to other Australian laboratories and will improve the national capacity for making further scientific discoveries about how the visual system works.Read moreRead less
Centre-surround interactions in ageing human vision. Australia has a rapidly ageing population. This project will study how ageing affects the visual perception of objects presented on non-uniform backgrounds. Our ability to discriminate objects from their backgrounds is key to most natural visual tasks. The visual processes involved are known as centre-surround interactions, and are considered fundamental building blocks to human perception. This project will significantly advance our knowledge ....Centre-surround interactions in ageing human vision. Australia has a rapidly ageing population. This project will study how ageing affects the visual perception of objects presented on non-uniform backgrounds. Our ability to discriminate objects from their backgrounds is key to most natural visual tasks. The visual processes involved are known as centre-surround interactions, and are considered fundamental building blocks to human perception. This project will significantly advance our knowledge of which spatial visual mechanisms are altered due to age, supplying key information for understanding and improving visual environments for the elderly, as well as increasing knowledge of the brain mechanisms susceptible to the ageing process.Read moreRead less
Listen and learn - statistical learning and the adapting auditory brain. This project aims to explore the link between rapid neural adaptation - a form of learning referred to as statistical learning - and human listening performance in noisy environments. The project aims to generate a new understanding of mechanisms that contribute to listeners' abilities to understand speech in noise, and to complex communication disorders such as dyslexia. Expected outcomes will include increased capacity to ....Listen and learn - statistical learning and the adapting auditory brain. This project aims to explore the link between rapid neural adaptation - a form of learning referred to as statistical learning - and human listening performance in noisy environments. The project aims to generate a new understanding of mechanisms that contribute to listeners' abilities to understand speech in noise, and to complex communication disorders such as dyslexia. Expected outcomes will include increased capacity to investigate a broad range of cognitive and communication functions. Benefits will include potential technologies and algorithms to assist listening (in devices such as hearing aids), language development and reading.Read moreRead less
Central Representation of Electroacoustic Stimuli. Cochlear implantation, initially only provided to profoundly deaf individuals, is now routine in people with substantial residual hearing. Although stimulation via a cochlear implant and hearing aid in the same ear has been shown to improve speech understanding, particularly in noise, and to increase the aesthetic quality of sound, almost nothing is known about the physiological mechanisms underlying these benefits. The broad aim of our project ....Central Representation of Electroacoustic Stimuli. Cochlear implantation, initially only provided to profoundly deaf individuals, is now routine in people with substantial residual hearing. Although stimulation via a cochlear implant and hearing aid in the same ear has been shown to improve speech understanding, particularly in noise, and to increase the aesthetic quality of sound, almost nothing is known about the physiological mechanisms underlying these benefits. The broad aim of our project is to address this deficiency by measuring the patterns of neural activity evoked by speech sounds across the tonotopic axis in the inferior colliculus and auditory cortex and assess the extent to which the pattern of neural activity allows discrimination between the different speech sounds.Read moreRead less
Understanding and Modelling Insect Motion Vision. The interdisciplinary project proposed will offer a stimulating environment for research/training into computational neuroscience, an attractive area for aspiring scientists. We have already demonstrated the feasibility of transferring physiology into applications, and expect this project to deliver functional motion vision models and devices. Our proposed work will have an impact beyond the advancement of neuro-physiology as knowledge gained is ....Understanding and Modelling Insect Motion Vision. The interdisciplinary project proposed will offer a stimulating environment for research/training into computational neuroscience, an attractive area for aspiring scientists. We have already demonstrated the feasibility of transferring physiology into applications, and expect this project to deliver functional motion vision models and devices. Our proposed work will have an impact beyond the advancement of neuro-physiology as knowledge gained is applicable in a range of areas, with applications in miniature unmanned vehicles and collision avoidance detectors in defence and civilian roles. Our project could also assist in the development of artificial intelligence and as a basis for designing implantable artificial eyes.Read moreRead less
Novel mechanisms for regulating the retinal vasculature. Tight control of the retinal vasculature is crucial for maintaining normal vision. Unlike most blood vessels in the body, those in the retina and brain receive no direct neural control. Rather they rely on support cells to communicate the needs of neurons. This project aims to examine the mechanisms by which resident immune cells, called microglia, regulate retinal capillaries in response to neural activity. New knowledge examining a novel ....Novel mechanisms for regulating the retinal vasculature. Tight control of the retinal vasculature is crucial for maintaining normal vision. Unlike most blood vessels in the body, those in the retina and brain receive no direct neural control. Rather they rely on support cells to communicate the needs of neurons. This project aims to examine the mechanisms by which resident immune cells, called microglia, regulate retinal capillaries in response to neural activity. New knowledge examining a novel mechanism will be generated. This information is crucial for enhancing our understanding of how blood vessels are controlled in the retina and brain and will guide the development of novel ways of examining blood vessel function.Read moreRead less