The project aims to improve cochlear implant performance via integrated gene therapy. A neurotrophin gene cassette will be delivered to cells adjacent to the electrode array using electrical pulses. This drives regeneration of the auditory nerve fibres and considerably improves cochlear implant performance. This study will optimize the therapeutic gene construct and cochlear implant –based gene delivery controller, and undertake an initial clinical trial to evaluate safety and efficacy.
Harnessing Anticalin Technology As A Multi-targeted Treament Approach For Vision Loss
Funder
National Health and Medical Research Council
Funding Amount
$627,273.00
Summary
Diabetes is a leading cause of vision loss and blindness worldwide and is caused by two factors called VEGF and Ang2, which damage blood vessels. Current treatments only block VEGF and many patients do not respond and suffer irreversible damage to sight. We have used ground-breaking anticalin technology to make a new drug (PRS-AUS1) that blocks both VEGF and Ang2. Studies will be performed in animal models and move to patients where we expect improved outcomes compared to current treatments.
Hear Assure: Saving Natural Hearing During Cochlear Implantation
Funder
National Health and Medical Research Council
Funding Amount
$1,058,537.00
Summary
Cochlear implants provide hearing by electrical stimulation of the hearing nerve. Even people receiving cochlear implants may have natural hearing, which is lost in up to 70% of patients through trauma caused during implantation. This is a major barrier to the adoption of cochlear implants. To overcome this, we will deliver Hear Assure, our novel hearing-monitoring product that is integrated with the cochlear implant, enabling safe positioning of the implant to minimise loss of natural hearing.
Novel Silk Devices For Reconstructive Surgery And Repair Of Tympanic Membrane Perforations
Funder
National Health and Medical Research Council
Funding Amount
$469,738.00
Summary
This project will use new silk fibroin materials to develop prototype devices for repair of ruptured ear drums. This will contribute to significant improvement in the quality of life of nearly 2.5 million people in Australia who are affected by hearing loss and further strengthen Australia's leading position in this area.