Identifying Novel Disease Genes In Abnormalities Of The Eye
Funder
National Health and Medical Research Council
Funding Amount
$123,454.00
Summary
The macula is located in the centre at the back of the eye and is essential for detailed and colour vision. There are familial forms of macular abnormalities and many elderly patients suffer from age-related macular degeneration. The gene function that is critical for the maintenance of a healthy macula is not fully known. In this project, a novel process in maintaining macular health will be investigated to identify the underlying genetic cause and associated functional defects.
The fovea is a specialized part of the retina which enables us to see fine detail. The fovea is characterised by an extremely high concentration of photoreceptor cells in a small, prescribed area to detect detail in the pattern of light reaching the retina. Each of these photoreceptor cells is connected to at least four other cells within the retina, which further refine the information coded by the photoreceptors. Because this circuitry involves so many cells, the retina has a tendency to be th ....The fovea is a specialized part of the retina which enables us to see fine detail. The fovea is characterised by an extremely high concentration of photoreceptor cells in a small, prescribed area to detect detail in the pattern of light reaching the retina. Each of these photoreceptor cells is connected to at least four other cells within the retina, which further refine the information coded by the photoreceptors. Because this circuitry involves so many cells, the retina has a tendency to be thick at the specialized area. However, in development the cells connected to the foveal photoreceptors move away from the central concentration of photoreceptors, still keeping their contacts with them. This results in thinning of the retina locally, so it has a volcanoe-like formation at the fovea, in which photoreceptors are concentrated within the crater and the displaced cells are accumulated on the rim. The events which trigger these cell displacements that form the fovea are unknown. We propose to investigate growth factors which signal between the fovea and the developing blood supply, and the relationship between the formation of the fovea and neuronal activity. This study will provide a new perspective on factors which affect central visual function and its vulnerability to insult in premature infants and in aging.Read moreRead less
Retinal Vascular Signs As Predictors Of Systemic Disease Outcomes: 10-year Evolution In A Population-based Cohort
Funder
National Health and Medical Research Council
Funding Amount
$389,575.00
Summary
Recent U.S. data from two population-based studies have highlighted retinal microvascular signs as being predictive of systemic vascular and other important health outcomes in middle-aged or older individuals, particularly stroke and heart attack and mortality, independent of traditional vascular risk factors. The present application proposes to evaluate the 10-year development and progression of retinal microvascular signs and their relations to the development of stroke and other important sys ....Recent U.S. data from two population-based studies have highlighted retinal microvascular signs as being predictive of systemic vascular and other important health outcomes in middle-aged or older individuals, particularly stroke and heart attack and mortality, independent of traditional vascular risk factors. The present application proposes to evaluate the 10-year development and progression of retinal microvascular signs and their relations to the development of stroke and other important systemic health outcomes in the population-based cohort of residents attending the Blue Mountains Eye Study (BMES. Two types of retinal signs will be evaluated: firstly, the presence of specific clinical signs, such as focal narrowing of small retinal vessels (arterioles), nicking of retinal veins as arterioles cross them or presence of retinopathy (haemorrhages and other signs) secondly, measures of generalized retinal vessel calibre (narrowing) using a computer-assisted method developed for the U.S. studies. We will also develop new grading methods for two other signs. Late and will compare computer-assisted grading from 35mm slides to automated grading of vessels using a scanning device (being developed) to screen the eyes of older persons. This project builds upon our current 3-year NHMRC grant (ID153948; 2001-2003) Retinal vascular signs as risk markers for incident stroke or cerebrovascular death: A population-based assessment . In the last 2 years, this has explored different aspects of measurement and grading of these signs, has documented their relation to blood pressure and has begun to assess whether these features predict vascular events and other systemic outcomes in older Australians. The new project will assess the evolution of retinal microvascular signs over a 10-year period, using data and retinal photographs from the 10-year examinations of the BMES cohort, currently being collected, in a further current NHMRC grant (ID211069; 2002-2004).Read moreRead less
Developing tests for the early detection of eye disease. Australians have a tradition of innovative design in perimetry. A good example being the Frequency Doubling Technology produced from work performed at the Australian National University. This technology, however, is manufactured by an overseas company (Welch Allyn, NY, USA). The Medmont company is a local perimeter manufacturer and we hope to improve their product with innovative design to yield a distinct marketing advantage. We will cons ....Developing tests for the early detection of eye disease. Australians have a tradition of innovative design in perimetry. A good example being the Frequency Doubling Technology produced from work performed at the Australian National University. This technology, however, is manufactured by an overseas company (Welch Allyn, NY, USA). The Medmont company is a local perimeter manufacturer and we hope to improve their product with innovative design to yield a distinct marketing advantage. We will consider the fundamental issues underlying cone-interactions and methods that stress retinal function. We believe that this approach will have advantages over conventional techniques and prove more sensitive for the early detection of eye disease. However, this is a high risk venture requiring substantial developmental cost and technical commitment by the company. Successful innovation will enhance the company's international penetration, continue the trend for Australians to be seen as leaders in this field and have impact on eye care.Read moreRead less
Histamine and non-visual regulation of retinal signalling. This project is internationally competitive, asking basic biological questions about the brain and vision. Of direct national benefit, the new knowledge generated may alter the way we understand how vision works. Ultimately this knowledge may give insight into particular health issues, such as the persistence of visual memory in Post Traumatic Stress Disorder, and age related diseases such as Alzheimer's disease. Further this new kno ....Histamine and non-visual regulation of retinal signalling. This project is internationally competitive, asking basic biological questions about the brain and vision. Of direct national benefit, the new knowledge generated may alter the way we understand how vision works. Ultimately this knowledge may give insight into particular health issues, such as the persistence of visual memory in Post Traumatic Stress Disorder, and age related diseases such as Alzheimer's disease. Further this new knowledge will flow directly into the reputation of our major institutes of higher education and strengthen their place on the world stage. Through both CIs, this research will contribute to the education of both undergraduate and postgraduate science students at The University of Melbourne. Read moreRead less
Optical defects of the eye and their relationship to visual performance. All of us will need ophthalmic correction (spectacles, contact lenses and/or refractive surgery) at some stage in our lives. This research is important to the whole Australian community as it will lead to improved equipment for measuring optics of the eye and their effects on spatial vision, better techniques for measuring vision, and obtaining a better understanding of the contribution of the optics to human vision. It wil ....Optical defects of the eye and their relationship to visual performance. All of us will need ophthalmic correction (spectacles, contact lenses and/or refractive surgery) at some stage in our lives. This research is important to the whole Australian community as it will lead to improved equipment for measuring optics of the eye and their effects on spatial vision, better techniques for measuring vision, and obtaining a better understanding of the contribution of the optics to human vision. It will provide information about how correcting optical defects through customized refractive surgery and how inducing optical defects (eg with progressive addition lenses) affect vision, and will thus guide developments in refractive surgery and spectacle lenses. Read moreRead less
Understanding lens aging: the molecular basis of presbyopia. Ageing has major consequences in the deterioration of vision, notably, the inability to focus on near objects. The understanding gained through this study of age-related lens changes may allow us to prescribe drugs or diets that alter lens properties and thus delay the need for glasses. This would have great benefits not just in decreased inconvenience of users, but also in cost to the middle-aged and elderly. In addition, data will b ....Understanding lens aging: the molecular basis of presbyopia. Ageing has major consequences in the deterioration of vision, notably, the inability to focus on near objects. The understanding gained through this study of age-related lens changes may allow us to prescribe drugs or diets that alter lens properties and thus delay the need for glasses. This would have great benefits not just in decreased inconvenience of users, but also in cost to the middle-aged and elderly. In addition, data will be used to underpin the development of a flexible intraocular lens (IOL). Hard IOLs are routinely inserted into human eyes following cataract surgery. In the future, flexible IOLs based on the properties of young lenses will be used, rather than reading glasses. This new industry could be based in Australia.Read moreRead less
Development Of A Slit Scanning Laser Ophthalmoscope As A Screening Tool In Glaucoma Diagnostics
Funder
National Health and Medical Research Council
Funding Amount
$195,830.00
Summary
Glaucoma is typified by progressive optic disc cupping and loss of fibres with consequent characteristic field defects. Direct imaging of the retina and quantitative assessment of such images greatly increases early diagnosis of this blinding disease. The proposed device, a laser line scanning ophthalmoscope, could support non-invasive imaging to obtain 3-D information in a simple and cost effective way. This could provide objective clinical parameters to support the decision making process.
Identifying tear lipids, their deposition onto contact lenses and their role in the development of dry eye. Lipids provide a critical layer in the human tear film that retards evaporation and helps nourish and protect the eye. We will identify the molecules within this essential "oil slick" to better understand dry eye syndrome and the discomfort associated with wearing contact lenses. This may lead to new treatments for dry eye and novel technologies that provide greater comfort for the ~120,00 ....Identifying tear lipids, their deposition onto contact lenses and their role in the development of dry eye. Lipids provide a critical layer in the human tear film that retards evaporation and helps nourish and protect the eye. We will identify the molecules within this essential "oil slick" to better understand dry eye syndrome and the discomfort associated with wearing contact lenses. This may lead to new treatments for dry eye and novel technologies that provide greater comfort for the ~120,000 Australians who wear contact lenses. This collaborative research directly supports the mission of a respected non-profit organisation (Institute for Eye Research) and will train scientists in world-leading analytical technologies that are essential to Australia's emerging biotechnology industries.Read moreRead less