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Discovery Early Career Researcher Award - Grant ID: DE120101434
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The role of outdoor activity in myopia development. It has recently been found that spending more time outdoors may reduce the risk of developing short sightedness. This project will examine the underlying basis of these associations and improve understanding of environmental factors involved in the cause of short sightedness, an eye problem that is a major cause of vision impairment globally.
Discovery Early Career Researcher Award - Grant ID: DE140100099
Funder
Australian Research Council
Funding Amount
$389,575.00
Summary
The importance of glia in the development of healthy blood vessels in the eye. The formation of healthy blood vessels in the eye is critical for vision. An important peptide in blood vessel formation throughout the body, including the eye, is Angiotensin II. Specific retinal cells named astrocytes and microglia are suggested to be involved in vessel formation. However, the way these cells control this formation is unknown. Using innovative techniques, this project will investigate how retinal as ....The importance of glia in the development of healthy blood vessels in the eye. The formation of healthy blood vessels in the eye is critical for vision. An important peptide in blood vessel formation throughout the body, including the eye, is Angiotensin II. Specific retinal cells named astrocytes and microglia are suggested to be involved in vessel formation. However, the way these cells control this formation is unknown. Using innovative techniques, this project will investigate how retinal astrocytes and microglia control glial-vascular communication and blood vessel formation via Angiotensin II. The information gained from this proposal is critical to our understanding of both normal retinal development and blood vessel maintenance in both infants and those of older ages.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100439
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Neural mechanisms of blindsight: a combined physiological and behavioural study. The cellular circuits of the cerebral cortex hold the key to the biological bases of perception, decision making, memory and consciousness. This project will study the physiological mechanisms underlying our ability to decide what we are seeing, based either on consciously perceived images or subconscious processing of visual information.
Discovery Early Career Researcher Award - Grant ID: DE130100868
Funder
Australian Research Council
Funding Amount
$336,284.00
Summary
Neural mechanisms of inhibitory control of human speech in stutterers and non-stutterers. Stopping oneself from speaking is a crucial communication function. In people who stutter, a disorder of this function causes their debilitating speech problem. This project will use cutting edge neuroimaging techniques to reveal how the brain stops speech in stutterers and in fluent speakers.
Discovery Early Career Researcher Award - Grant ID: DE120101931
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Functional imaging with cellular resolution in the living eye. Adaptive optics allows the visualisation of individual cells and capillaries in the living human eye. This project will use adaptive optics to explore the normal function of these microscopic objects, and how this function changes in eyes suffering from disease. This will aid in developing new ways to diagnose and treat debilitating eye diseases.
Discovery Early Career Researcher Award - Grant ID: DE120101311
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Role of intrinsic versus extrinsic cues in cell type determination during development and regeneration. During development all of the different cell types are generated by the action of genes and also signals from the embryo that read out which cell types are present or missing. This project studies how much environmental signals affect cell type generation developmentally and if they can be used to regenerate only the types missing in different diseases.
Discovery Early Career Researcher Award - Grant ID: DE220100323
Funder
Australian Research Council
Funding Amount
$417,505.00
Summary
I can't find the word! Reading to maintain communication skills in ageing. This project aims to investigate why, as we age, we have trouble retrieving words when we speak but not when we read aloud. It takes the novel approach of systematically testing both reading and speaking in the same older adults. Through its innovative use of both behavioural research and computational modelling, it will generate new knowledge in spoken word production and reading, areas in which the project team have ack ....I can't find the word! Reading to maintain communication skills in ageing. This project aims to investigate why, as we age, we have trouble retrieving words when we speak but not when we read aloud. It takes the novel approach of systematically testing both reading and speaking in the same older adults. Through its innovative use of both behavioural research and computational modelling, it will generate new knowledge in spoken word production and reading, areas in which the project team have acknowledged expertise. This project will advance theories, achieving understanding of how ageing affects the cognitive systems involved in saying words and reading them aloud. By also investigating whether reading aloud can support word retrieval, it has potential future benefit for improved communication in older adults.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100783
Funder
Australian Research Council
Funding Amount
$409,781.00
Summary
Music and speech as a window into the predictive brain . Prediction is fundamental to daily life, and yet we know little about how this central process works in the brain. This research program aims to provide in-depth insight into predictive processing by investigating the precise, culturally relevant, and communicative domains of music and speech. The research expects to reveal cognitive and neural correlates of “what” will occur and “when” it will occur, while exploiting the musician brain as ....Music and speech as a window into the predictive brain . Prediction is fundamental to daily life, and yet we know little about how this central process works in the brain. This research program aims to provide in-depth insight into predictive processing by investigating the precise, culturally relevant, and communicative domains of music and speech. The research expects to reveal cognitive and neural correlates of “what” will occur and “when” it will occur, while exploiting the musician brain as a model for plasticity. Expected outcomes include a multi-dimensional model of prediction and its neural markers that will lay the foundation to investigate impaired predictive processing. This should substantially benefit health and education by providing perspectives for training and rehabilitation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100320
Funder
Australian Research Council
Funding Amount
$394,371.00
Summary
Understanding cone photoreceptor migration and cell death mechanisms . Normal vision requires functional and correctly located cone photoreceptor cells. Many genetic mutations, however, impair the correct migration of these cells during development and ultimately cause cell death. This project will investigate, for the first time, the casual link between the migration of cone cells and activation of cell death mechanisms. A coordinated approach, using a range of molecular techniques, will be use ....Understanding cone photoreceptor migration and cell death mechanisms . Normal vision requires functional and correctly located cone photoreceptor cells. Many genetic mutations, however, impair the correct migration of these cells during development and ultimately cause cell death. This project will investigate, for the first time, the casual link between the migration of cone cells and activation of cell death mechanisms. A coordinated approach, using a range of molecular techniques, will be used to determine which factors are essential for normal development, correct spatial location and survival of cone photoreceptors within the mammalian retina. This will provide a major step forward in our knowledge of the processes involved in the spatial deployment of cones and the developmental organisation of the retina.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101424
Funder
Australian Research Council
Funding Amount
$434,282.00
Summary
Molecular basis of Prestin’s electromotility and sound discrimination . Sonar animals like whales can hear at exceptionally high frequencies allowing them to echolocate. Humans, though, can hear at much higher frequencies than reptiles and birds. Frequency sensing mainly depends on a protein in the ear called Prestin. Currently, the structure and working mechanism of Prestin is unknown. This project aims to characterize how Prestin responds to high frequencies by probing the electro-mechanical f ....Molecular basis of Prestin’s electromotility and sound discrimination . Sonar animals like whales can hear at exceptionally high frequencies allowing them to echolocate. Humans, though, can hear at much higher frequencies than reptiles and birds. Frequency sensing mainly depends on a protein in the ear called Prestin. Currently, the structure and working mechanism of Prestin is unknown. This project aims to characterize how Prestin responds to high frequencies by probing the electro-mechanical force generated using mechanically gated channels as a reporter. Single particle cryo-electron microscopy will also be used to visualize Prestin’s 3D structure. Together, this DECRA project will elucidate the molecular basis of hearing differences across species and reshapes our understanding of the evolution of hearing.Read moreRead less