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Improving the performance of Australian social insurance schemes. Applying methods from computational social science, this project aims to develop a novel, multi-level modeling framework to assist transport injury, workplace injury and disability insurance schemes consistently achieve and maintain standards of high performance as recognised by international benchmarks. By creating a virtual laboratory for policy-makers and scheme managers, it expects to generate a comprehensive understanding of ....Improving the performance of Australian social insurance schemes. Applying methods from computational social science, this project aims to develop a novel, multi-level modeling framework to assist transport injury, workplace injury and disability insurance schemes consistently achieve and maintain standards of high performance as recognised by international benchmarks. By creating a virtual laboratory for policy-makers and scheme managers, it expects to generate a comprehensive understanding of mechanisms driving insurance scheme performance, enabling comparison of anticipated outcomes in response to legislative changes, policy changes and management decisions. The project aims to help schemes avoid human and financial failure, benefitting people with injuries and disabilities while reducing scheme costs.Read moreRead less
Modelling the population impact of injury. This project aims to model the long-term, population impact of non-fatal injury through the use of cutting edge epidemiological modelling, sophisticated biostatistics, advanced econometrics, and geospatial analysis. The project will use population-based, linked longitudinal data to generate new knowledge about the long-term impacts of injury, cost of injury, and expected burden into the future. Through the multi-disciplinary and multi-national collabo ....Modelling the population impact of injury. This project aims to model the long-term, population impact of non-fatal injury through the use of cutting edge epidemiological modelling, sophisticated biostatistics, advanced econometrics, and geospatial analysis. The project will use population-based, linked longitudinal data to generate new knowledge about the long-term impacts of injury, cost of injury, and expected burden into the future. Through the multi-disciplinary and multi-national collaborations established, it is anticipated that this project may lead to future changes in public health and social policy, prioritisation of injury prevention efforts, and establish the capacity to evaluate injury interventions and policy shifts as they occur.Read moreRead less
Modelling, Identification and Control of Complex Networks. Australia has been well known for its leading research in systems and control and many real-world applications in, for instance, telecommunications, defence, power grids and life sciences. This project will further promote Australia's leading position in the emerging new research field - complex networks by theoretical breakthrough in modelling, identification and control of complex networks, and cutting-edge platform technology that can ....Modelling, Identification and Control of Complex Networks. Australia has been well known for its leading research in systems and control and many real-world applications in, for instance, telecommunications, defence, power grids and life sciences. This project will further promote Australia's leading position in the emerging new research field - complex networks by theoretical breakthrough in modelling, identification and control of complex networks, and cutting-edge platform technology that can help Australian energy industry to reduce greenhouse emissions. It will also result in education of the next generation research leaders in this emerging field.Read moreRead less
Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide. There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precociou ....Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide. There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precocious puberty. Kisspeptin and RF-related peptide may offer more physiological alternatives to GnRH, without detrimental side effects. We will fully explore these two newly defined and major players in reproduction and provide a physiological framework for their progression to clinical use.Read moreRead less
Understanding brain mechanisms that control autonomic function. This project aims to understand the how the brain regulates sympathetic nerve activity, thereby increasing our understanding of the biology and function of nascent neurons on the adult brain stem. This challenges the current notion that new neurons are only made during development. The project will also determine how brain inflammation impacts blood-brain barrier function and affects sympathetic nerve regulation. The basic fundament ....Understanding brain mechanisms that control autonomic function. This project aims to understand the how the brain regulates sympathetic nerve activity, thereby increasing our understanding of the biology and function of nascent neurons on the adult brain stem. This challenges the current notion that new neurons are only made during development. The project will also determine how brain inflammation impacts blood-brain barrier function and affects sympathetic nerve regulation. The basic fundamental insights and conceptual advances into how autonomic function is controlled by the brain will provide a better understanding of these fundamental processes and will contribute to Australia’s priority research areas to improve health and advance product development.Read moreRead less
Resolving multi-sensory conflict as we age: audio-visual integration and the role of normal and abnormal sensory decline. Australia has an ageing population. Even the healthiest older individuals undergo some deterioration of vision and hearing, however, these senses are almost invariably studied in isolation. The real world is multisensory. This project will enhance our knowledge of how ageing impacts on the interpretation of visual and auditory information regarding the timing and location of ....Resolving multi-sensory conflict as we age: audio-visual integration and the role of normal and abnormal sensory decline. Australia has an ageing population. Even the healthiest older individuals undergo some deterioration of vision and hearing, however, these senses are almost invariably studied in isolation. The real world is multisensory. This project will enhance our knowledge of how ageing impacts on the interpretation of visual and auditory information regarding the timing and location of objects; essential precursors to many real world tasks, for example: driving, interpreting speech, and hazard avoidance. This knowledge is essential for the optimisation of audio-visual environments for the elderly, and for the development of tools to improve performance in the presence of sensory decline due to age-related eye disease.Read moreRead less
Unified digital networking for wireless and optical access. The provision of broadband services is a high priority for the Australian government as evidenced by the various initiatives around Australia. The merging of backbone infrastructures for access environment will overcome unnecessary cost of maintaining and upgrading two separate networks for wired and wireless applications. The merged infrastructure will potentially provide inexpensive and cost-effective solutions for truly broadband ser ....Unified digital networking for wireless and optical access. The provision of broadband services is a high priority for the Australian government as evidenced by the various initiatives around Australia. The merging of backbone infrastructures for access environment will overcome unnecessary cost of maintaining and upgrading two separate networks for wired and wireless applications. The merged infrastructure will potentially provide inexpensive and cost-effective solutions for truly broadband services with a choice of wired or wireless connectivity to customers and will remove the rural-urban broadband divide that has been challenging Australia. The outcomes of this project can lead to new business ventures and will further strengthen the telecommunication industry.Read moreRead less
How appetite-suppressing brain cells maintain normal function and prevent the development of obesity. The brain plays a critical role in body weight gain by balancing appetite-inducing and appetite-suppressing signals. An imbalance in this process causes obesity and promotes diabetes. The aim of this research is to identify how appetite-suppressing brain cells maintain normal function and prevent the development of obesity.
Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement. This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, ....Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement. This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, as well as the nabarlek itself, the developmental processes and genes involved in molar generation and movement will be revealed. This project will integrate findings in regenerative medicine, evolutionary biology, materials engineering and palaeontology to reveal the mechanisms and origins of this astounding capability.Read moreRead less
The regulation of skeletal muscle mass. This project aims to delineate a pathway involved in regulating skeletal muscle mass, and examine whether disrupting mitochondrial phospholipid synthesis affects mitochondrial structure and function, causing muscle wasting. Defining a new atrophy pathway will advance understanding of the mechanisms that control muscle mass. This project could have important economic and quality of life benefits, especially for agriculture, where achieving optimal muscle ma ....The regulation of skeletal muscle mass. This project aims to delineate a pathway involved in regulating skeletal muscle mass, and examine whether disrupting mitochondrial phospholipid synthesis affects mitochondrial structure and function, causing muscle wasting. Defining a new atrophy pathway will advance understanding of the mechanisms that control muscle mass. This project could have important economic and quality of life benefits, especially for agriculture, where achieving optimal muscle mass ensures international competitiveness, productivity and economic growth, and successful ageing, where maintaining muscle mass is essential.Read moreRead less