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Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide. There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precociou ....Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide. There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precocious puberty. Kisspeptin and RF-related peptide may offer more physiological alternatives to GnRH, without detrimental side effects. We will fully explore these two newly defined and major players in reproduction and provide a physiological framework for their progression to clinical use.Read moreRead less
Resolving multi-sensory conflict as we age: audio-visual integration and the role of normal and abnormal sensory decline. Australia has an ageing population. Even the healthiest older individuals undergo some deterioration of vision and hearing, however, these senses are almost invariably studied in isolation. The real world is multisensory. This project will enhance our knowledge of how ageing impacts on the interpretation of visual and auditory information regarding the timing and location of ....Resolving multi-sensory conflict as we age: audio-visual integration and the role of normal and abnormal sensory decline. Australia has an ageing population. Even the healthiest older individuals undergo some deterioration of vision and hearing, however, these senses are almost invariably studied in isolation. The real world is multisensory. This project will enhance our knowledge of how ageing impacts on the interpretation of visual and auditory information regarding the timing and location of objects; essential precursors to many real world tasks, for example: driving, interpreting speech, and hazard avoidance. This knowledge is essential for the optimisation of audio-visual environments for the elderly, and for the development of tools to improve performance in the presence of sensory decline due to age-related eye disease.Read moreRead less
The regulation of skeletal muscle mass. This project aims to delineate a pathway involved in regulating skeletal muscle mass, and examine whether disrupting mitochondrial phospholipid synthesis affects mitochondrial structure and function, causing muscle wasting. Defining a new atrophy pathway will advance understanding of the mechanisms that control muscle mass. This project could have important economic and quality of life benefits, especially for agriculture, where achieving optimal muscle ma ....The regulation of skeletal muscle mass. This project aims to delineate a pathway involved in regulating skeletal muscle mass, and examine whether disrupting mitochondrial phospholipid synthesis affects mitochondrial structure and function, causing muscle wasting. Defining a new atrophy pathway will advance understanding of the mechanisms that control muscle mass. This project could have important economic and quality of life benefits, especially for agriculture, where achieving optimal muscle mass ensures international competitiveness, productivity and economic growth, and successful ageing, where maintaining muscle mass is essential.Read moreRead less
Excessive sitting and population health: strengthening the science and the relevance to policy and practice. The majority of Australian adults spend most of their waking hours sitting; this increases the likelihood of developing diseases of inactivity, including diabetes, heart disease and some cancers. New research will investigate what factors encourage excessive sitting and what the health benefits are for people who deliberately do less sitting.
The life-course implications of declining adolescent drinking. The project aims to identify ways to ensure that recent declines in adolescent drinking are maintained and reinforced as these cohorts age into young adulthood. It expects to generate new knowledge on the trajectories of youth drinking into young adulthood. Expected outcomes include new cross-national understandings of the predictors of heavy drinking in adulthood and an updated evidence base for the development of harm prevention po ....The life-course implications of declining adolescent drinking. The project aims to identify ways to ensure that recent declines in adolescent drinking are maintained and reinforced as these cohorts age into young adulthood. It expects to generate new knowledge on the trajectories of youth drinking into young adulthood. Expected outcomes include new cross-national understandings of the predictors of heavy drinking in adulthood and an updated evidence base for the development of harm prevention policies and interventions by governments and NGOs. This should provide significant benefits to Australia via reductions in the negative health and social impacts of heavy drinking for these cohorts across their lives. Read moreRead less
Optimal Control of Multi-Object System. Better understanding of multi-object systems developed from this research, in particular, optimal control algorithms for multi-object systems have several significant socio-economic benefits. Application areas that benefits from our research include aerospace applications such as radar, sonar, guidance, navigation, and air traffic control and non-aerospace areas such as image processing, oceanography autonomous vehicles and robotics, remote sensing, and bi ....Optimal Control of Multi-Object System. Better understanding of multi-object systems developed from this research, in particular, optimal control algorithms for multi-object systems have several significant socio-economic benefits. Application areas that benefits from our research include aerospace applications such as radar, sonar, guidance, navigation, and air traffic control and non-aerospace areas such as image processing, oceanography autonomous vehicles and robotics, remote sensing, and biomedical research. The sensor network discipline also stand to benefit from the understanding of multi-object system and control framework. Read moreRead less
State, Class and Islamic Populism: Indonesia in Comparative Perspective. This study will provide a different basis for the assessment of Australian policy responses to Islamic radicalism in Indonesia. It will expose the social foundations of Islamic populism as a particular expression of political Islam and in so doing allow the Australian public and policymakers to understand the complex networks and relationships that generate and sustain Islamic populism, including its radical streams. It wil ....State, Class and Islamic Populism: Indonesia in Comparative Perspective. This study will provide a different basis for the assessment of Australian policy responses to Islamic radicalism in Indonesia. It will expose the social foundations of Islamic populism as a particular expression of political Islam and in so doing allow the Australian public and policymakers to understand the complex networks and relationships that generate and sustain Islamic populism, including its radical streams. It will enable an identification and differentiation of the social forces resisting or advancing democratic governance reforms in Indonesia. With this knowledge, programmes intended to help develop domestic pro-democratic coalitions to stem the rise of radical Islamic groups have a sounder social scientific base.Read moreRead less
Highly efficient electric power and value-added synthesis gas co-generation from methane with zero greenhouse gas emission. This project addresses a novel sealing-free solid oxide fuel cell system producing simultaneously synthesis gas and electricity from methane with zero greenhouse gas emission. The project aims to deliver economic benefits and contribute to environmental protection and increased employment opportunities.
Analysing and comparing concepts of addiction for improved social and health outcomes in Australia. Australia invests heavily in responding to alcohol and other drug (AOD) use. This project will analyse a key concept shaping AOD responses, namely addiction. The analysis will help develop new, more productive approaches to AOD prevention, education and treatment, contributing to improved AOD-related social and health outcomes.