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Coverage with Evidence Development: Application to pharmaceutical reimbursement decisions. Some new medicines produce only a small improvement in health but have considerable costs. When these medicines are trialled on only small numbers of people, uncertainty results about the value of the medicine, which can create problems for decision makers. Funding medicines where there is uncertainty may lead to harm when medicines are later found to be unsafe, or waste millions of dollars when they are ....Coverage with Evidence Development: Application to pharmaceutical reimbursement decisions. Some new medicines produce only a small improvement in health but have considerable costs. When these medicines are trialled on only small numbers of people, uncertainty results about the value of the medicine, which can create problems for decision makers. Funding medicines where there is uncertainty may lead to harm when medicines are later found to be unsafe, or waste millions of dollars when they are overpriced relative to effectiveness. Not funding medicines may disadvantage patients in whom the medicines are effective. Methods to enable access to medicines while reducing uncertainty will offer significant benefit to patients, clinicians and taxpayers. Read moreRead less
Excessive sitting and population health: strengthening the science and the relevance to policy and practice. The majority of Australian adults spend most of their waking hours sitting; this increases the likelihood of developing diseases of inactivity, including diabetes, heart disease and some cancers. New research will investigate what factors encourage excessive sitting and what the health benefits are for people who deliberately do less sitting.
Incentives and performance in the health care system. Changes in financial incentives for health care providers will have direct effects on their behaviour, which in turn influences patients' health outcomes, quality of care, and access to health care for the population. The research will provide a richer understanding of the effects of incentives, and will influence policy on the design of incentives for health care providers in Australia. Changes in incentives will ensure patients receive mo ....Incentives and performance in the health care system. Changes in financial incentives for health care providers will have direct effects on their behaviour, which in turn influences patients' health outcomes, quality of care, and access to health care for the population. The research will provide a richer understanding of the effects of incentives, and will influence policy on the design of incentives for health care providers in Australia. Changes in incentives will ensure patients receive more appropriate, higher quality, and less costly health care, in the most appropriate settings, and delivered by the most appropriate health care providers. This will have direct effects on population health and well-being and the capacity of individuals to lead healthy and productive lives.Read moreRead less
Developing an evidence base to improve the health of Aboriginal and Torres Strait Islander people. This project addresses two critical health needs for Indigenous Australians, namely cancer and infectious diseases. It will test interventions in each area with the aim of improving health outcomes.
Developing a research focus on the health and quality of life of adolescents in the Northern Territory. The Youth Futures program will focus on the health and well being of adolescents in the Northern Territory, 40 per cent of whom are Indigenous. This project will provide an evidence base to inform health policy, identify transformative life skills and the ways to translate these into practice.
MOLECULAR APPROACHES TO OVERCOME SCABIES AND ASSOCIATED DISEASE. Scabies causes childhood pyoderma predisposing to severe disease in later life. It is a major increasing health burden in Indigenous people of Northern Australia. Drug resistance is developing in mites and bacteria. The lack of clinical material has hampered molecular research and this work will use comparative genomics of parasitic and free living mites and microbiome analysis to understand fundamental aspects of mite biology and ....MOLECULAR APPROACHES TO OVERCOME SCABIES AND ASSOCIATED DISEASE. Scabies causes childhood pyoderma predisposing to severe disease in later life. It is a major increasing health burden in Indigenous people of Northern Australia. Drug resistance is developing in mites and bacteria. The lack of clinical material has hampered molecular research and this work will use comparative genomics of parasitic and free living mites and microbiome analysis to understand fundamental aspects of mite biology and pathogenesis. The understanding of proteins that are essential for mite survival and interfere with host defences will allow the informed design of peptide inhibitors as a new strategy to develop alternative treatment options.Read moreRead less
Closing the gap in Aboriginal maternal and child health outcomes. This project will build the evidence base needed to design and implement effective strategies to close the gap in Aboriginal maternal and child health outcomes and reduce Indigenous disadvantage across the life course.
Improving Outcome after Stroke through Earlier Rehabilitation: The Very Early Rehabilitation Research Program. Stroke presents a major, growing global public health challenge accounting for 25% of all chronic disability. Treatments that reduce the burden of stroke are urgently needed, and early rehabilitation may significantly reduce chronic disability. A large, high quality, National Health and Medical Research Council funded clinical trial is at the heart of the A Very Early Rehabilitation Tri ....Improving Outcome after Stroke through Earlier Rehabilitation: The Very Early Rehabilitation Research Program. Stroke presents a major, growing global public health challenge accounting for 25% of all chronic disability. Treatments that reduce the burden of stroke are urgently needed, and early rehabilitation may significantly reduce chronic disability. A large, high quality, National Health and Medical Research Council funded clinical trial is at the heart of the A Very Early Rehabilitation Trial (AVERT) program. The trial tests whether a simple, rehabilitation intervention (early and intensive out of bed activity) results in fewer deaths and less disability for stroke sufferers and is cost effective. If effective the intervention could be adopted across different health services both here and overseas, reducing the global burden of stroke.Read moreRead less
Understanding bilingual language acquisition in northern Indigenous Australia: phonological, lexical, orthographic, and family factors. Children's language outcomes are critical for health, social inclusion, education and employment. In northern Australia many Indigenous children grow up as Kriol/English bilinguals in disadvantaged communities; this research will establish the linguistic, educational, and family factors in successful language acquisition for these children.
A critical public health examination of complementary self-medication in later life in indigenous, non-indigenous and CALD communities. This project aims to provide the first in-depth coordinated critical public health examination of an unregulated and 'covert' area of health and treatment seeking behaviour - complementary self-medication (CAM SM) use in later life. It will focus on healthy ageing and living with chronic illness and draw upon fieldwork with Indigenous, non-Indigenous and cultura ....A critical public health examination of complementary self-medication in later life in indigenous, non-indigenous and CALD communities. This project aims to provide the first in-depth coordinated critical public health examination of an unregulated and 'covert' area of health and treatment seeking behaviour - complementary self-medication (CAM SM) use in later life. It will focus on healthy ageing and living with chronic illness and draw upon fieldwork with Indigenous, non-Indigenous and culturally and linguistically diverse (CALD) communities. This project aims to identify the challenges of, and possibilities for, 'covert' CAM SM use in later life. It will provide an evidence-base to inform safe, effective care and policy for older Australians and generate novel analyses to provide significant advances and new directions for public health scholarship with regards to chronic illness and community health in later life.Read moreRead less