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The Chief Investigators have worked as a team for 20 years as part of a successful NHMRC Program Grant that was renewed on three successive occasions and subsequently under a NHMRC Block Grant to QIMR. Their combined expertise covers the whole spectrum from the bedside to the bench with respect to clinical studies and fundamental molecular studies of iron homeostasis. The common theme of iron homeostasis and iron overload pervades virtually all the research of the team. The team�s research has l ....The Chief Investigators have worked as a team for 20 years as part of a successful NHMRC Program Grant that was renewed on three successive occasions and subsequently under a NHMRC Block Grant to QIMR. Their combined expertise covers the whole spectrum from the bedside to the bench with respect to clinical studies and fundamental molecular studies of iron homeostasis. The common theme of iron homeostasis and iron overload pervades virtually all the research of the team. The team�s research has led to fundamental observations of iron regulation and homeostasis and the development of guidelines for the management of, and screening for, haemochromatosis, recognized as the most common inherited disorder of Caucasian populations. The proposed research encompasses molecular studies aimed at deciphering the mechanisms of iron absorption and transport; how these processes are regulated; and clinical studies on patients diagnosed with haemochromatosis. The findings are particularly pertinent to the diagnosis, management and prevention of clinical haemochromatosis.Read moreRead less
I am a neuroscientist employing strategies of anatomy, biochemistry, pharmacology, genetics and behavioural analysis to examine the physiological and possible pathological roles of newly discovered neuropeptides and their cognate receptors in mammalian brain. My recent research has focused on the highly-conserved, abundant peptide, relaxin-3 that was discovered at the HFI in 2002. Studies so far have revealed that relaxin-3 is a powerful modulator of rhythmic brain activity (theta) and spatial m ....I am a neuroscientist employing strategies of anatomy, biochemistry, pharmacology, genetics and behavioural analysis to examine the physiological and possible pathological roles of newly discovered neuropeptides and their cognate receptors in mammalian brain. My recent research has focused on the highly-conserved, abundant peptide, relaxin-3 that was discovered at the HFI in 2002. Studies so far have revealed that relaxin-3 is a powerful modulator of rhythmic brain activity (theta) and spatial memory, and alters feeding, body weight and arousal. Relaxin-3 levels in brain are also strongly activated by acute stress. In the future, I aim to elucidate further the role of relaxin-3 systems in normal physiology and metabolic and-or psychiatric diseases.Read moreRead less