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From developmental stability to organismic senility: Hox genes and telomere impact on life history evolution. Australia benefits from training researchers and technicians in new, break-through biotechnology and from applying this knowledge to relevant, cutting-edge questions in highly publicized research fields. This project contains both these ingredients. Our model species (a lizard) has a relatively high level of offspring malformations (ca 15%), which makes it much more likely to detect thei ....From developmental stability to organismic senility: Hox genes and telomere impact on life history evolution. Australia benefits from training researchers and technicians in new, break-through biotechnology and from applying this knowledge to relevant, cutting-edge questions in highly publicized research fields. This project contains both these ingredients. Our model species (a lizard) has a relatively high level of offspring malformations (ca 15%), which makes it much more likely to detect their underlying genetic mechanism. Furthermore, we can also assess how these animals survive and reproduce in relation to how quickly they age, which can be measured by assessing the shortening of telomeres per unit time. Thus, this collaboration provides an opportunity to train Australian researchers and in that process generate very high profile research.Read moreRead less
Evaluation of a multidimensional cognitive enhancement training program for healthy older adults. The percentage of the Australian population aged 65 years and over is projected to increase considerably over the next 50 years. The increased number of older Australians will have a major economic cost in terms of income support and the provision of health services. It is of high socioeconomic importance, therefore, to promote functional independence in this group. The implementation of cognitive e ....Evaluation of a multidimensional cognitive enhancement training program for healthy older adults. The percentage of the Australian population aged 65 years and over is projected to increase considerably over the next 50 years. The increased number of older Australians will have a major economic cost in terms of income support and the provision of health services. It is of high socioeconomic importance, therefore, to promote functional independence in this group. The implementation of cognitive enhancement programs that may slow age-related cognitive decline and, thereby, maximise quality of life and independence for a long as possible will have significant national benefit.Read moreRead less
Identifying the specific structural features of metallothionein that regulate its ability to modulate astrogliosis. This project contributes directly to the Designated National Research Priority 2 and could potentially have a significant impact upon the broader Australian Community by identifying a novel and powerful therapeutic agent based upon metallothionein proteins with the ultimate aim of helping patients who have a brain injury or a neurodegenerative disease. It is important to note that ....Identifying the specific structural features of metallothionein that regulate its ability to modulate astrogliosis. This project contributes directly to the Designated National Research Priority 2 and could potentially have a significant impact upon the broader Australian Community by identifying a novel and powerful therapeutic agent based upon metallothionein proteins with the ultimate aim of helping patients who have a brain injury or a neurodegenerative disease. It is important to note that the partnership between UTAS and Bestenbalt LLC is a critical step in the development of these exciting research discoveries into commercially viable outcomes for the Australian Biotechnology Industry and the broader Australian community.Read moreRead less
Using metallothioneins as a model for understanding cellular and biochemical interactions between neurons and astrocytes within the brain. This research will reveal some of the changes that occur in the relationship between neurons and astrocytes as a consequence injury, aging or disease to the human brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or in neurodegenerative diseases. These a ....Using metallothioneins as a model for understanding cellular and biochemical interactions between neurons and astrocytes within the brain. This research will reveal some of the changes that occur in the relationship between neurons and astrocytes as a consequence injury, aging or disease to the human brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or in neurodegenerative diseases. These are significant community issues in both economical and social terms. Furthermore, this research contributes directly to the Designated National Research Priorities by identifying some of the earliest cellular processes associated with aging or disease of the brain, and will provide clues to promoting healthy aging.Read moreRead less
Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to th ....Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or neurodegenerative disease. Furthermore, this research contributes directly to the Designated National Research Priorities by identifying some of the earliest biochemical and cellular processes associated with aging or disease of the brain.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100015
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Purchase of an ultra-performance liquid chromatograph - triple quadrupole mass spectrometer. The diverse research supported by the proposed instrument group addresses several national research priorities. It will lead to a better fundamental understanding of the hormonal control of plant growth, improved catalysts for organic synthesis including pharmaceuticals and improved food safety. In forestry it will help to increase forest productivity through mitigating losses from insect and mamm ....Purchase of an ultra-performance liquid chromatograph - triple quadrupole mass spectrometer. The diverse research supported by the proposed instrument group addresses several national research priorities. It will lead to a better fundamental understanding of the hormonal control of plant growth, improved catalysts for organic synthesis including pharmaceuticals and improved food safety. In forestry it will help to increase forest productivity through mitigating losses from insect and mammalian pests and enhancing wood quality. In pharmaceutics, improved treatments for asthma are expected. This facility will provide the infrastructure essential for many researchers to maintain internationally competitive profiles in their areas and continue to offer postgraduate training and postdoctoral opportunities.Read moreRead less