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From Functional Genomics To Precision Medicine: Identifying The Cause And Finding Optimal Therapy For Oral Squamous Cell Carcinoma
Funder
National Health and Medical Research Council
Funding Amount
$855,992.00
Summary
There is an alarming increase in mouth cancer in young patients who have never smoked. This is a debilitating and potentially fatal cancer without many treatment options. If the patient survives, the quality of life is usually very poor. Our team of medical, genetic, and mathematics experts are dedicated to finding the cause, and developing new treatments, for young non-smoking patients affected by this devastating cancer.
Aurora A As A Novel Therapeutic Target For HPV-driven Cancers.
Funder
National Health and Medical Research Council
Funding Amount
$762,328.00
Summary
Cervical cancer is caused by a virus and current treatments have not improved for many years. We have performed a screen and identified new drug targets and here we will examine one of these using a drug that has perviously been developed for other cancers. Our preliminary data shows cervical cancer is highly sensitive to this drug and there are few side-effects. We will examine how it works and if it results in permanent protection from new cancers.
Facial palsy is a devastating condition which has a very significant psychological and cosmetic impact. A simple and effective treatment does not exist for facial palsy. Our research goal is use state-of-the-art technology to define the types and the severity of the underlying nerve injury so that effective treatments can be developed to treat this terrible disorder.
Molecular And Epidemiological Investigation Of Cutaneous Squamous Cell Carcinoma Of The Head And Neck With Perineural Invasion
Funder
National Health and Medical Research Council
Funding Amount
$42,862.00
Summary
Queensland has the highest recorded rates of skin cancer in the world. Invasion into nearby nerves or �perineural invasion� occurs in approximately 5% of cases. This signifies that the tumour is aggressive and able to spread along nerves back to the brain and reduce survival. Why some tumours invade nerves remains unclear. This project will study the factors involved and the characteristics of affected patients to enable a better understanding of the disease and potentially improve treatment.
Improving Quality Of Life In High-risk Cancer Populations: A Randomised Trial Of A Structured Intervention For Head And Neck Cancer Survivors
Funder
National Health and Medical Research Council
Funding Amount
$493,220.00
Summary
Patients treated for head and neck cancer commonly experience pain, disfigurement, eating difficulties, depression and fatigue, undermining confidence and quality of life. This study aims to help patients self-manage their ongoing health problems following completion of treatment. This will be achieved through a randomised trial in which patients will be assisted by a trained oncology nurse to develop a tailored survivorship care plan focusing on the patient’s specific medical and emotional conc ....Patients treated for head and neck cancer commonly experience pain, disfigurement, eating difficulties, depression and fatigue, undermining confidence and quality of life. This study aims to help patients self-manage their ongoing health problems following completion of treatment. This will be achieved through a randomised trial in which patients will be assisted by a trained oncology nurse to develop a tailored survivorship care plan focusing on the patient’s specific medical and emotional concerns.Read moreRead less
Much of the death and suffering caused by cancer is associated with secondary tumours, but alot remains to be learned about how cancer spreads through the patient's body. This project will determine how genes that enable the growth of tumours work with other genes that enable cancer cells to detach from the tumour, enabling them to enter the bloodstream and form secondary tumours in other organs.
Oral Human Papillomavirus Infection In Head And Neck Cancers And The General Population.
Funder
National Health and Medical Research Council
Funding Amount
$422,800.00
Summary
Mucosal cancers of the head and neck are the sixth most common type of cancer worldwide and are increasing in Australia. Human papillomaviruses (HPV), which are the major cause of cervical cancer and the cause of 5% of all human cancers, have recently also been implicated as a cause of some types of head and neck cancer, especially in patients younger than 50 years. In this project we will investigate how HPV infection regulates the expression of key genes in cancers of the head and neck, and ho ....Mucosal cancers of the head and neck are the sixth most common type of cancer worldwide and are increasing in Australia. Human papillomaviruses (HPV), which are the major cause of cervical cancer and the cause of 5% of all human cancers, have recently also been implicated as a cause of some types of head and neck cancer, especially in patients younger than 50 years. In this project we will investigate how HPV infection regulates the expression of key genes in cancers of the head and neck, and how that affects prognosis of this disease.Read moreRead less
A Randomized Trial Of 2 Radiation And Systemic Therapy Strategies In Good Prognosis Advanced Human Papilloma Virus -associated Cancer Of The Tonsil And Base Of Tongue
Funder
National Health and Medical Research Council
Funding Amount
$1,097,932.00
Summary
Cancers of the tonsil and base of tongue due to the human papilloma virus have a better prognosis than other head and neck cancers, but standard treatment can result in significant acute and late side effects. This trial aims to compare two types of chemotherapy and radiotherapy that are less intensive than standard treatment. The aim of the trial is to determine which treatment is associated with better quality of life and less side effects, while maintaining efficacy.
Best Evidence To Best Practice: Implementing An Innovative Model Of Care For Nutritional Management Of Patients With Head And Neck Cancer
Funder
National Health and Medical Research Council
Funding Amount
$276,250.00
Summary
This project aims to implement and evaluate an innovative best-practice dietetic model of care (MOC) based on published Evidence Based Guidelines for Nutritional Management of Patients with Head and Neck Cancer. Through integration with the multidisciplinary team, the MOC will take a patient-centred approach to delivery of nutritional care to minimise the detrimental sequelae of malnutrition and improve outcomes in this complex patient group.