The Australian Research Data Commons (ARDC) invites you to participate in a short survey about your
interaction with the ARDC and use of our national research infrastructure and services. The survey will take
approximately 5 minutes and is anonymous. It’s open to anyone who uses our digital research infrastructure
services including Reasearch Link Australia.
We will use the information you provide to improve the national research infrastructure and services we
deliver and to report on user satisfaction to the Australian Government’s National Collaborative Research
Infrastructure Strategy (NCRIS) program.
Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
Complete the 5 min survey now by clicking on the link below.
Interactions Between Haematopoietic, Bone, Vascular And Endocrine Systems Control Stem Cell Fate And Mobilization
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
Haemopoietic stem cells (HSC) normally reside in the bone marrow (BM) where they make blood and immune cells. We can force HSC to move from the BM into the blood, a process called mobilisation, used to collect large numbers of HSC for transplantation into cancer patients. My research involves identifying factors that control HSC fate within the BM (that is survival, growth, differentiation) and what happens during mobilisation to force them to leave with the aim of improving transplant success.
Overcoming Immunosenescence For Effective Stem Cell Therapies
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
An established treatment for blood cancers involves a stem cell transplant to replace the blood stem cells that are damaged by radiation and chemotherapy. However, treatment success is limited with advancing age due to multiple defects in the immune system. We will use new technologies to investigate how the ageing immune system copes with stem cell transplantation and explore new methods for improving recovery and immunity after HSCT.
Transcriptional Regulation Of Hematopoietic Commitment
Funder
National Health and Medical Research Council
Funding Amount
$289,985.00
Summary
Blood cell formation is a tightly regulated process and provides an important model for our understanding of blood homeostasis. Perturbations result in a number of disorders such as leukaemia. The application of stem cells to many diseases is being pursued; yet, to be successful knowledge of normal cellular behavior is crucial. I aim to improve our understanding of these processes and help to provide the framework for future studies aimed at more directly manipulating blood cell functions.
The Role Of Cell Cycle Control In Haemopoietic Stem Cell Fate Decisions.
Funder
National Health and Medical Research Council
Funding Amount
$390,974.00
Summary
My research has focused on understanding how the process of cell division can result in different outcomes for adult blood stem cells. I am interested in determining the role of bone and blood vessels in the regulation of blood stem cells and in the development of blood diseases (myeloprolifertive disease). I will also determine the effects of changing the cell cycle with drugs to improve transplantation of blood stem cells.
The emerging interdisciplinary field, mechanobiology, is focused on understanding how cells sense their surroundings and transfer biomechanical signals to initiate cellular changes. I aim to develop hydrogel platforms with differential stiffness patterns to study cellular mechanotransduction and to generate heart muscle cells. The findings have the potential to greatly improve the clinical outcomes where more than 10 clinical trials failed to show successful regeneration after heart attack.
Mechanisms Underlying The Effects Of Retinoic Acid Receptor Gamma In Haemopoiesis And Bone Homeostasis
Funder
National Health and Medical Research Council
Funding Amount
$366,801.00
Summary
My recent studies have demonstrated that a model of vitamin A deficiency results in impaired blood cell production and contributes to a blood cell disorder that can progress to leukaemia. There are also reduced numbers of blood stem cells (which give rise to all blood cells) and bone (which helps to regulate blood cell production) in this mouse model. In these studies I seek to understand more on how vitamin A deficiency causes these defects, which may lead to better treatment of such diseases.
Stem And Progenitor Cell Contribution To Skin Wounds And Homeostasis
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
Skin wounds represent a major health and economic burden. Although skin stem cells have been used routinely for the treatment of wounds, they cannot reconstitute a fully functional skin given the complexity and the many cell types usually involved in wound healing. In this project, we intend to evaluate the role of different cell populations on modulating skin wound healing to produce more regeneration and less scaring.
Using Connective Tissue Stem Cells To Treat Human Disease.
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
In our recent Cell paper (January 15, 2015), we reported our discovery of two new adult stem cells. One of these, the osteochondroreticular (OCR) bone stem cell (pronounced “ocker” stem cell) has a particular affinity for developing cartilage. We are testing if this cell could be used as a new treatment for osteoarthritis. The second new stem cell we discovered, is called the iRSC, and lies within the intestine. We are studying this cell in the development and treatment of bowel cancer.