Solid phase synthesis of side-chain cross-linked peptide oligomers. This research will provide a unique opportunity to investigate the biological pathways and causative factors leading to diseases such as Alzheimer’s disease. Such information will guide the design and development of therapeutic strategies and diagnostic reagents.
The mode of action of the haem protein neuroglobin in protecting nerve cells. Outcomes from this project will assist in developing new treatments for stroke and chronic degenerative brain disorders by characterising how the haem protein neuroglobin protects neurons of the central and peripheral nervous system from oxidative damage. This project will also develop pharmacological strategies to boost the concentration of neuroglobin in neurons.
Understanding the role of methionine oxidation in amyloid formation. Amyloid deposition is associated with many debilitating systemic and neurological diseases, including Alzheimer's disease. This project aims to understand the effect of protein oxidation on the process of amyloid fibril formation. This knowledge will assist in the discovery of the triggers of these disorders and may identify methods of combating them.
Investigating the intercellular trafficking of proteins and RNA and its relevance to neurodegenerative diseases. Alzheimer's and prion diseases are neurodegenerative disorders associated with protein misfolding. This project brings together similar features of these diseases using novel cell- and animal-based studies to develop a greater understanding of the molecular basis of these disorders.