Hot carrier cooling mechanisms in nano structures. This project aims to systematically investigate possible mechanisms of hot carrier cooling in nano structures and to identify the most dominant mechanisms. These are important for efficient hot carrier solar cells and thermoelectrics. This project will develop new physics to understand hot carrier dynamics in nano structures. This project is expected to result in photovoltaic systems with a lower balance of system and levelised cost of electrici ....Hot carrier cooling mechanisms in nano structures. This project aims to systematically investigate possible mechanisms of hot carrier cooling in nano structures and to identify the most dominant mechanisms. These are important for efficient hot carrier solar cells and thermoelectrics. This project will develop new physics to understand hot carrier dynamics in nano structures. This project is expected to result in photovoltaic systems with a lower balance of system and levelised cost of electricity compared to conventional technologies. This should boost solar industry, create green jobs and reduce greenhouse gas emissions.Read moreRead less
How does an essential histone variant effect changes in gene expression? The mechanisms that determine how genes are switched on and off in different tissues and at different times are not clearly known. It is well established that gene expression patterns are determined in part by the molecular signals transmitted by variation in the proteins that package eukaryotic DNA. Our aim is to understand new aspects of these mechanisms that revolve around how our DNA is packaged. This foundational knowl ....How does an essential histone variant effect changes in gene expression? The mechanisms that determine how genes are switched on and off in different tissues and at different times are not clearly known. It is well established that gene expression patterns are determined in part by the molecular signals transmitted by variation in the proteins that package eukaryotic DNA. Our aim is to understand new aspects of these mechanisms that revolve around how our DNA is packaged. This foundational knowledge will deepen our understanding of gene regulation in all complex organisms and will inform future efforts to rationally modulate gene expression patterns in agriculture, research and other important areas.Read moreRead less
Deciphering the regulatory principles of metazoan development. This proposal aims to elucidate how regulatory elements in the genome, known as enhancers, determine the identity and function of animal tissues. Currently, it is believed that enhancers cannot be traced across evolutionarily distant animals. The project uses novel concepts, computational and molecular approaches to identify deeply conserved enhancers. It further dissects the mechanism of function by proteomics and high-throughput ge ....Deciphering the regulatory principles of metazoan development. This proposal aims to elucidate how regulatory elements in the genome, known as enhancers, determine the identity and function of animal tissues. Currently, it is believed that enhancers cannot be traced across evolutionarily distant animals. The project uses novel concepts, computational and molecular approaches to identify deeply conserved enhancers. It further dissects the mechanism of function by proteomics and high-throughput genomics. The expected outcomes will overturn our current view on enhancer evolution and reposition our understanding of how enhancers are functionally encoded in the genome. The work is an important contribution to understanding cellular complexity and species evolution with wide-ranging impact in genetics.Read moreRead less
Biomimetic Design and Fabrication of Smart Dry Adhesives. Gecko footpads have unique structures with amazing features; imitating these fine bio-structures will lead to a multitude of innovations. This project aims to study fundamental principles governing adhesion phenomena for creating entirely new biomimetic nanomaterials with tunable adhesion, self-cleaning and controlled release capabilities. The gecko-mimicking materials and the associated dynamic effects will be characterized quantitativel ....Biomimetic Design and Fabrication of Smart Dry Adhesives. Gecko footpads have unique structures with amazing features; imitating these fine bio-structures will lead to a multitude of innovations. This project aims to study fundamental principles governing adhesion phenomena for creating entirely new biomimetic nanomaterials with tunable adhesion, self-cleaning and controlled release capabilities. The gecko-mimicking materials and the associated dynamic effects will be characterized quantitatively at multiscales and the nanoscale phenomena will be linked to macroscopic performance. The results of this research should provide a fundamental understanding of tunable adhesion mechanisms for the design and development of optimized materials with superb performance of practical significance.
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Productivity, growth and unemployment in economies with frictions. This project aims to examine decisions driving productivity, growth, and unemployment in macroeconomies with frictions. It examines how government (fiscal, monetary, and education) policies determine these decisions, and identifies the best configurations of these policies. It will construct dynamic general equilibrium models of economies to analyse the causal structure behind productivity changes, growth and unemployment. It wil ....Productivity, growth and unemployment in economies with frictions. This project aims to examine decisions driving productivity, growth, and unemployment in macroeconomies with frictions. It examines how government (fiscal, monetary, and education) policies determine these decisions, and identifies the best configurations of these policies. It will construct dynamic general equilibrium models of economies to analyse the causal structure behind productivity changes, growth and unemployment. It will conduct quantitative experiments using simulations, to estimate optimal government policy design settings. This project expects to identify policies that promote productivity, growth and employment.Read moreRead less
Improving payments for ecosystem services efficacy. This project aims to improve the cost-effectiveness of payments for ecosystem services (PES) programs in settings where deforestation risk is high. The project introduces a field experiment in Uganda in order to determine effective methods for monitoring compliance and setting payment levels. The project intends to examine whether program impacts are undermined by displacement of deforestation and if there are poverty reduction trade-offs inher ....Improving payments for ecosystem services efficacy. This project aims to improve the cost-effectiveness of payments for ecosystem services (PES) programs in settings where deforestation risk is high. The project introduces a field experiment in Uganda in order to determine effective methods for monitoring compliance and setting payment levels. The project intends to examine whether program impacts are undermined by displacement of deforestation and if there are poverty reduction trade-offs inherent in program design. The project expects to establish the costs of foregone production from land enrolled in the program, which are largely unknown. The findings will support efforts to create low cost technologies to solve conservation challenges and assist with the efficient allocation of scarce resources for environmental protection in both Australian and international contexts.Read moreRead less
How does the chromatin remodeller CHD4 regulate gene expression? The mechanisms that determine how genes are switched on and off in different tissues and at different times are in many ways still mysterious. It is well established that gene expression patterns in complex organisms are determined in part by the manner in which DNA is physically packaged. Our aim is to define new aspects of these mechanisms that revolve around molecular motors that regulate DNA packaging. This foundational knowled ....How does the chromatin remodeller CHD4 regulate gene expression? The mechanisms that determine how genes are switched on and off in different tissues and at different times are in many ways still mysterious. It is well established that gene expression patterns in complex organisms are determined in part by the manner in which DNA is physically packaged. Our aim is to define new aspects of these mechanisms that revolve around molecular motors that regulate DNA packaging. This foundational knowledge will deepen our understanding of gene regulation in all complex organisms and will inform future efforts to rationally modulate gene expression patterns in agriculture, research and other important areas.Read moreRead less
Understanding Mitotic Telomere Deprotection. This project aims to study telomeres, the DNA and protein structures that protect chromosome ends. During cell division, cells under stress intentionally uncap their telomeres. This project expects to generate new knowledge that challenges the conventional notion of telomeres as static elements, showing instead that telomeres can be dynamic signalling hubs. Expected outcomes of this project include an understanding of the genetic, proteomic, and signa ....Understanding Mitotic Telomere Deprotection. This project aims to study telomeres, the DNA and protein structures that protect chromosome ends. During cell division, cells under stress intentionally uncap their telomeres. This project expects to generate new knowledge that challenges the conventional notion of telomeres as static elements, showing instead that telomeres can be dynamic signalling hubs. Expected outcomes of this project include an understanding of the genetic, proteomic, and signalling pathways involved in this novel phenomenon. This should provide significant benefits to our fundamental understanding of biological processes that protect human genomes and provide a valuable dataset for research on telomere biology, DNA repair, and genome stability.Read moreRead less
Banking System Competition and the Macro-economy. Australia has one of the most concentrated banking sectors in the world, generating concerns regarding its efficiency. This project aims to develop unified frameworks to understand and evaluate quantitatively how the structure of the banking industry affects the macro-economy and provide policy recommendations for establishing a healthy and efficient banking industry. This project expects to improve understanding of the welfare trade-off between ....Banking System Competition and the Macro-economy. Australia has one of the most concentrated banking sectors in the world, generating concerns regarding its efficiency. This project aims to develop unified frameworks to understand and evaluate quantitatively how the structure of the banking industry affects the macro-economy and provide policy recommendations for establishing a healthy and efficient banking industry. This project expects to improve understanding of the welfare trade-off between bank competition and economic well-being to enable policymakers to better determine the optimal concentration of banking sector in Australia. This will enhance the productivity and international competitiveness of Australia’s financial system and the broader economy.Read moreRead less
Large dynamic time-varying models for structural macroeconomic inference. This project aims to broaden the range of macroeconomic models that have an integrated capacity for both greater realism and efficiency in analysis. This approach will be applied to two contexts at the forefront of current macroeconomic research, the effects of noisy productivity signals on business cycles and the effects of fiscal policy shocks. Flexible macro-econometric models underpin accurate inference by economists ....Large dynamic time-varying models for structural macroeconomic inference. This project aims to broaden the range of macroeconomic models that have an integrated capacity for both greater realism and efficiency in analysis. This approach will be applied to two contexts at the forefront of current macroeconomic research, the effects of noisy productivity signals on business cycles and the effects of fiscal policy shocks. Flexible macro-econometric models underpin accurate inference by economists and policymakers and the project outputs should provide widespread and significant benefits by improving policy and boosting Australia’s comparative advantage.Read moreRead less