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Development Of A Novel MicroRNA Mimic For Cancer Treatment
Funder
National Health and Medical Research Council
Funding Amount
$534,179.00
Summary
Liver cancer is a major health burden globally, with a very poor prognosis. New treatments are urgently needed. We have developed proof-of-concept data showing that a tiny RNA, called a microRNA, is a powerful inhibitor of liver cancer growth. We will use this grant application to further develop the microRNA with novel chemistry so that it can be readily translated into early phase clinical trials in the near future.
A Bispecific Antibody To Synergise Checkpoint Blockers In Oncology
Funder
National Health and Medical Research Council
Funding Amount
$636,492.00
Summary
Cancer hides from the immune system in its earliest stages by evading immune surveillance and a cell type named myeloid derived suppressor cell (MDSC) has been identified as the main accomplice in this evasion. Currently, there is no drugs able to specifically target those cells. Here, we will develop a new drug that will prevent their recruitment to the tumors. We believe that when use in synergy with recent immunotherapies, it will dramatically improve survival in cancer patients.
Development Of A Humanised Antibody For Treatment Of Cancer And Stroke
Funder
National Health and Medical Research Council
Funding Amount
$242,800.00
Summary
This grant explores the ability of novel monoclonal antibodies to inhibit cancer cell growth, and to prevent complications in patients with brain injuries. The results of this work will enable the development of new strategies for antibody-based therapy of many types of cancer, and improve outcomes in patients suffering from acute stroke.
Novel Therapy For Enhancing Organ Maturation In Pre-term Babies
Funder
National Health and Medical Research Council
Funding Amount
$694,323.00
Summary
This project is developing a factor to enhance organ maturation and repair that may provide a new therapy for premature babies and fetuses with birth defects. This exciting new finding allows for the development of treatments of underdeveloped organs, in particular the lungs of premature and growth restricted babies. We are also trialing this factor in unborn babies with defects to the kidneys and lungs of which there is currently no cure.