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Defining The Role Of Plasminogen Activation In Group A Streptococcal Invasive Disease
Funder
National Health and Medical Research Council
Funding Amount
$425,763.00
Summary
The "flesh-eating" bacteria group A streptococcus (GAS) causes life threatening invasive diseases such as necrotizing fasciitis and toxic shock syndrome (>600,000 cases and 163,000 deaths per year). For some types of GAS, plasminogen binding is essential for virulence.The aim of this work is to determine the extent to which plasminogen binding contributes to disease caused by highly virulent GAS. These studies will allow the development of new therapeutics and treatments.
Understanding Respiratory Infections To Improve Vaccines
Funder
National Health and Medical Research Council
Funding Amount
$268,497.00
Summary
Indigenous children have the highest rates of ear disease (OM) and associated hearing loss in the world. Papua New Guinea has the highest child mortality rates in the Western Pacific Region with 23% of deaths from pneumonia. OM and pneumonia vaccines can be improved through broadening their coverage of disease-causing pathogens. This study will identify the pathogens that currently cause OM in Indigenous children and pneumonia in PNG, and will measure the immune responses to these pathogens, in ....Indigenous children have the highest rates of ear disease (OM) and associated hearing loss in the world. Papua New Guinea has the highest child mortality rates in the Western Pacific Region with 23% of deaths from pneumonia. OM and pneumonia vaccines can be improved through broadening their coverage of disease-causing pathogens. This study will identify the pathogens that currently cause OM in Indigenous children and pneumonia in PNG, and will measure the immune responses to these pathogens, in order to develop improved vaccines.Read moreRead less
Vaccine Discovery For Human Mucosal Pathogens: Identifying Novel Vaccine Antigens That Are Stably Expressed During Host Interactions, Using Analysis Of Cell-contact And Phasevarion Mediated Expression Profiles
Funder
National Health and Medical Research Council
Funding Amount
$418,482.00
Summary
The control of several human pathogens depends on vaccine development due to antibiotic resistance and the devastating outcome of infection. This work aims to identify new vaccine targets for diseases including gonorrhoae, ear infections, meningitis and sepsis, based on proteins required for interaction with human cells. Proteins that are randomly switched on and off in these bacteria will also be studied to better understand disease and to rule out variably expressed genes from new vaccines.
The Role Of The Complement System In Neurodegeneration And The Therapeutic Potential Of Complement Inhibition
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
This project aims to identify the role of immune and inflammatory components in the pathology of neurodegenerative disease. Additionally, this research will determine whether a new class of novel anti-inflammatory drugs can alter the neurodegenerative process. This will allow for an increased understanding of the biology of neurodegenerative disease, and also may lead to the development of new treatments for conditions such as Parkinson’s disease, Huntington’s disease and motor neuron disease.
Investigatin The Causes Of Failed Efferocytosis In COPD-emphysema With A View To Identifying Novel Theraputic Targets
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
COPD is a leading cause of death. Smoking is the major cause of COPD and many sufferers are left with permanent damage and need ongoing treatment even after smoking cessation. Current treatments for COPD generally have limited efficacy. The project will identify the reason for the large number of dying cells and defective clearance of these cells that we have identified in the airways in COPD and study novel treatments that we hope will improve the health and well being of those with COPD.
Gene Discovery And Pathobiology In Muscle Diseases
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
I aim to find the genetic causes of muscle diseases that are lethal or severely debilitating. These diseases result in a significant burden to the affected individuals and their families and also on Australia’s Health care system. A genetic diagnosis provides families with answers, allows family planning, such that couples do not have another affected child, enables appropriate clinical management and gives researchers evidence as to how to develop treatments.