CSF-1 Regulation Of Macrophage Adhesion And Motility And Promotion Of Tumour Invasion And Metastasis
Funder
National Health and Medical Research Council
Funding Amount
$323,453.00
Summary
Macrophages, a type of white blood cell, infiltrate tumours and encourage tumour cells to metastasize. The mechanism involves secretion of a macrophage motility factor, CSF-1, by the tumour cells and secretion of a tumour cell motility factor by the macrophages to stimulate co-migration, invasion and metastasis. CSF-1 controls macrophage motility via the CSF-1 receptor. Dissection of receptor signalling pathways to macrophage motility will identify therapeutic targets to prevent tumour spread.