Blood Group Antigen Recognition By Group A Streptococcus Mediates Host Colonisation
Funder
National Health and Medical Research Council
Funding Amount
$470,821.00
Summary
Group A streptococcus (GAS) is responsible for approximately 700 million cases of localised infection and 600,000 cases of invasive infection globally each year. Certain bacteria have been shown to recognise sugars (known as glycans) on host cells. This project will look at how GAS use sugars at the surface of host cells to initiate disease, and determine if differences in the types of sugars present on host cells alter the ability of GAS to initiate infection.
The Role Of Lipooligosaccharide Phosphoethanolamine Transferases In The Pathogenesis Of Neisseria Meningitidis And N. Gonorrhoeae
Funder
National Health and Medical Research Council
Funding Amount
$574,890.00
Summary
Neisseria meningitidis is the causative agent of meningococcal disease, a rapidly transmissible form of fatal sepsis. The related pathogen, N. gonorrhoeae, causes the sexually transmitted gonorrhoeae and is implicated in the loss of fertility in 10% of patients. This project will analyse the function of a protein necessary for the ability of the both pathogens to cause disease. We will further characterize the function of this protein and determine whether it is a viable candidate for the develo ....Neisseria meningitidis is the causative agent of meningococcal disease, a rapidly transmissible form of fatal sepsis. The related pathogen, N. gonorrhoeae, causes the sexually transmitted gonorrhoeae and is implicated in the loss of fertility in 10% of patients. This project will analyse the function of a protein necessary for the ability of the both pathogens to cause disease. We will further characterize the function of this protein and determine whether it is a viable candidate for the development of drug therapy.Read moreRead less