The Extinction Of Conditioned Fear And Its Implications For Cue Exposure Therapy
Funder
National Health and Medical Research Council
Funding Amount
$322,430.00
Summary
This project studies extinction of Pavlovian conditioned fear reactions in rats. Extinction of these reactions is an animal model for exposure therapy used in the treatment of anxiety disorders in people. In exposure therapy, the patient, aided by the clinician, confronts trauma-related cues in the absence of any overt danger. The intention of this therapy is to reduce the ability of the trauma-related cues to provoke the fear reactions that are undermining the patient's quality of life. In Pavl ....This project studies extinction of Pavlovian conditioned fear reactions in rats. Extinction of these reactions is an animal model for exposure therapy used in the treatment of anxiety disorders in people. In exposure therapy, the patient, aided by the clinician, confronts trauma-related cues in the absence of any overt danger. The intention of this therapy is to reduce the ability of the trauma-related cues to provoke the fear reactions that are undermining the patient's quality of life. In Pavlovian conditioning, subjects (typically rats) are exposed to a signaling relation between an initially neutral stimulus (e.g., a noise) and a feared outcome (e.g., foot shock). When later repeatedly exposed to the initially neutral but now feared stimulus (the noise) in the absence of the feared outcome, the fear reactions it acquired progressively decline until eventually it fails to elicit any such reactions. The fear reactions are said to have been extinguished. There has been significant progress in understanding the psychological processes and neural mechanisms underlying the acquisition of fear reactions, but much less is known about the processes and mechanisms underlying the extinction of these reactions. The project has two general objectives. The first is to determine the conditions of extinction training that promote long-term loss of fear reactions. The second objective is to determine how the brain controls this extinction of learned fear. Achieving these aims will be significant for two reasons. First, it will contribute to understanding the mechanisms by which animals (including people) learn to adjust their behaviour to bring it into line with the current relations that exist between events in the world. Second, it will provide important information about how such adjustment is facilitated or impaired across extinction training and, thereby, contribute towards understanding both the successes and failures of cue exposure therapy for fear-related disorders.Read moreRead less
The primary aim of this grants to determine how HIV spreads through our immune system. The above knowledge will determine key Achille’s Heel moments in the HIV life cycle and thus lead to better therapeutic HIV treatments/prevention.
The Treatment Of BOoking Gestational Diabetes Mellitus Study: The TOBOGM Study
Funder
National Health and Medical Research Council
Funding Amount
$2,197,280.00
Summary
Gestational diabetes mellitus (GDM) related pregnancy complications are reduced with treatment from 24-28 weeks pregnant. Many women are diagnosed/treated earlier without evidence of benefit and possible risk of harm. In TOBOGM women under 20 weeks pregnant with mildly raised blood glucose will be allocated by chance to either immediate treatment, or awaiting a repeat diabetes test at 24-28 weeks pregnant to decide treatment. Harmful and beneficial effects on mother and baby will be compared.
How Does Paternal Obesity Influence Offspring Glucose Tolerance?
Funder
National Health and Medical Research Council
Funding Amount
$503,398.00
Summary
Obesity and diabetes are closely related to these conditions in either parent, but how the father contributes is unclear. We have shown that normal females mated with obese fathers consuming high fat diet, produce offspring who develop glucose intolerance and impaired insulin secretion. This work will examine the mechanisms underlying this effect in the rat, testing a novel role for environmental factors in the father on disease in offspring that may be relevant to the growing obesity epidemic.
'As-if thinking': an experimental analysis of human reasoning and decision-making. The failure to respond adequately to the havoc wreaked by Hurricane Katrina in 2005 highlighted the difficulty of sequential decision-making. Responses to such emergencies require detailed contingency plans, necessitating a consideration of all possible outcomes of a situation regardless of their objective probability. This project takes an innovative approach to the experimental analysis of human reasoning and de ....'As-if thinking': an experimental analysis of human reasoning and decision-making. The failure to respond adequately to the havoc wreaked by Hurricane Katrina in 2005 highlighted the difficulty of sequential decision-making. Responses to such emergencies require detailed contingency plans, necessitating a consideration of all possible outcomes of a situation regardless of their objective probability. This project takes an innovative approach to the experimental analysis of human reasoning and decision-making, with the aim of identifying the mechanisms, factors, and boundary conditions affecting inferences and decisions about uncertain alternatives. The research will inform planning for Australia's readiness to respond to unpredictable events with uncertain outcomes and enhance the reputation of Australian science.Read moreRead less
Music cognition in infants, children and adults. Music is an important tool for the expression of emotion and transmission of culture. One approach to understanding why music is a human universal is to examine how people process musical structure - the simultaneous and sequential pitch relations among tones of musical pieces. We investigate the way humans acquire implicit and explicit knowledge of such relations and the way exposure to music influences acquisition. Three experiments involving in ....Music cognition in infants, children and adults. Music is an important tool for the expression of emotion and transmission of culture. One approach to understanding why music is a human universal is to examine how people process musical structure - the simultaneous and sequential pitch relations among tones of musical pieces. We investigate the way humans acquire implicit and explicit knowledge of such relations and the way exposure to music influences acquisition. Three experiments involving infants, children and adults will compare formal musical training with incidental learning. Results will increase knowledge of the development of auditory perception and music cognition. Infant perceptual predispositions hold implications for music education.Read moreRead less
Associability processes in propositional learning. A novel attentional model of learning is evaluated in this project. In this model, learning is seen not as a consequence of a low-level, evolutionarily old system shared with our ancestors, but as a product of our capacity to apply rules and engage in reasoning. Understanding the role of attention in learning will allow a better understanding of the attentional biases seen in clinical disorders such as addiction and a new way to think about the ....Associability processes in propositional learning. A novel attentional model of learning is evaluated in this project. In this model, learning is seen not as a consequence of a low-level, evolutionarily old system shared with our ancestors, but as a product of our capacity to apply rules and engage in reasoning. Understanding the role of attention in learning will allow a better understanding of the attentional biases seen in clinical disorders such as addiction and a new way to think about the neuroscience of attention. These benefits may further suggest new lines of research in the development of drugs to combat attentional disorders.Read moreRead less
A new theory of visual word recognition and reading aloud. The results of this research will lead to an improvement in the theory of reading, which will in turn improve the quality of advice to speech pathologists, teachers, parents and the broader community about children’s reading difficulties and their treatment.
Studies of lexical contagion: Interactions between lexical and episodic memory. Episodic memory allows us to recognize previously experienced items or events. Lexical memory represents orthographic (spelling), phonological (sound) and semantic (meaning) information about words. This project applies recent developments in the study of lexical memory to systematically investigate orthographic and phonological effects on episodic memory for words and nonwords. The new findings will be compared with ....Studies of lexical contagion: Interactions between lexical and episodic memory. Episodic memory allows us to recognize previously experienced items or events. Lexical memory represents orthographic (spelling), phonological (sound) and semantic (meaning) information about words. This project applies recent developments in the study of lexical memory to systematically investigate orthographic and phonological effects on episodic memory for words and nonwords. The new findings will be compared with well known semantic effects that give rise to false memories. The results will be important for evaluating and developing unified models of memory, and providing objectively defined stimulus materials and baselines of memory performance that can be used in applied research.Read moreRead less
Masked priming in the Bayesian Reader. This project brings three benefits. One is scientific, by advancing understanding of unconscious cognition, and of automatic aspects of word recognition. This will lead to the second, applied benefit in developing better assessment tools for reading skill. The third benefit is in enhancing Australia's growing reputation in word recognition research by strengthening links with a top international researcher, as well as providing research training opportun ....Masked priming in the Bayesian Reader. This project brings three benefits. One is scientific, by advancing understanding of unconscious cognition, and of automatic aspects of word recognition. This will lead to the second, applied benefit in developing better assessment tools for reading skill. The third benefit is in enhancing Australia's growing reputation in word recognition research by strengthening links with a top international researcher, as well as providing research training opportunities for Australia's future researchers via international collaboration. Read moreRead less