The project will evaluate the impact of transition care and service integration models on older people and their carers in three States, as well as the use of resources and costs of the services; evaluate the implementation and operation of transition care and service integration models by determining conditions that would assist-inhibit implementation from the viewpoint of older people, their carers and formal care givers; and develop and validate quality, cost and continuity of service integra ....The project will evaluate the impact of transition care and service integration models on older people and their carers in three States, as well as the use of resources and costs of the services; evaluate the implementation and operation of transition care and service integration models by determining conditions that would assist-inhibit implementation from the viewpoint of older people, their carers and formal care givers; and develop and validate quality, cost and continuity of service integration in different settings.Read moreRead less
Reprogramming Macrophage Function In The Elderly To Rescue Impaired Inflammatory Responses To Muscle Injury
Funder
National Health and Medical Research Council
Funding Amount
$410,983.00
Summary
Muscle injury in the elderly often takes longer to heal than in younger people, however the cells responsible for this delayed healing are not well understood. Key inflammatory cells required for muscle repair in young hosts are macrophages. However, during aging we have shown that macrophage function is altered, but the mechanism is unknown. This project aims to determine the mechanisms behind age-related changes to macrophages and whether they can be targeted to improve elderly muscle repair.
Telehealth In Residential Aged Care Facilities: Improving Access To Specialist Care
Funder
National Health and Medical Research Council
Funding Amount
$972,606.00
Summary
People in long term residential care have complex and chronic care issues. The staff may be able to provide more focused care if they have the support of specialists for advice on the care of residents. This project considers the value of a geriatric specialist assessment for all new residents via video conferencing, directly to the residential care facility. This will be supplemented by access to a wide range of other specialists coordinated through a telehealth service model on an "as needs" b ....People in long term residential care have complex and chronic care issues. The staff may be able to provide more focused care if they have the support of specialists for advice on the care of residents. This project considers the value of a geriatric specialist assessment for all new residents via video conferencing, directly to the residential care facility. This will be supplemented by access to a wide range of other specialists coordinated through a telehealth service model on an "as needs" basis.Read moreRead less
Predicting Health And Disease In Australian Men Over The Age Of 80 Years - The Health In Men Study
Funder
National Health and Medical Research Council
Funding Amount
$528,754.00
Summary
Australia is ageing rapidly but we still do not know whether the risk factors, such as health and lifestyle, that predict ill health in middle aged people, apply to people as they reach old age. This study of a large group of older men will examine the type and level of risk factors that apply to men aged beyond 75 years. It will not only determine rates of disability and mortality but also health service outcomes, including hospitalisation, and residential and community care usage.
Prevention And Management Of Mental Disorders In Older Australians
Funder
National Health and Medical Research Council
Funding Amount
$2,486,509.00
Summary
Dementia, mild cognitive impairment and depression are the major neuropsychiatric problems that Australia’s ageing population will face in the next 50 years. With the rapid advances in neuroscience, we need a cohort of young researchers who can translate this knowledge into better health outcomes for older Australians. The Brain and Ageing Program (B and AP) at the University of New South Wales (UNSW) has identified potential future leaders who will develop key research themes to improve the men ....Dementia, mild cognitive impairment and depression are the major neuropsychiatric problems that Australia’s ageing population will face in the next 50 years. With the rapid advances in neuroscience, we need a cohort of young researchers who can translate this knowledge into better health outcomes for older Australians. The Brain and Ageing Program (B and AP) at the University of New South Wales (UNSW) has identified potential future leaders who will develop key research themes to improve the mental health of older Australians. This grant will enable them to take on this challenge.Read moreRead less
Promoting Activity For Frail Aged In Post-acute Hospital Settings: A Randomised Controlled Trial Of Accelerometry
Funder
National Health and Medical Research Council
Funding Amount
$542,119.00
Summary
Keeping older people in hospital actively mobile is a vital objective of high quality aged care. Using accelerometers, the Centre for Research in Geriatric Medicine at the University of Queensland, and its partner, the CSIRO e-health Research Centre, are trialing a method of promoting activity in older rehabilitation patients. Potentially, a system of _activity management� could solve an age old problem in hospital care of older people.
The effect of mitochondrial and nuclear-cytoplasmic variation on longevity, metabolism and stress resistance in Drosophila. Much research points to a major role of free radical damage in aging, thus the belief that antioxidants might be beneficial in delaying aging. Free radicals are mostly formed in the subcellular organelles which consume oxygen and produce energy, and this may be the major site of age-related damage. This project seeks to understand the degree to which variation among these ....The effect of mitochondrial and nuclear-cytoplasmic variation on longevity, metabolism and stress resistance in Drosophila. Much research points to a major role of free radical damage in aging, thus the belief that antioxidants might be beneficial in delaying aging. Free radicals are mostly formed in the subcellular organelles which consume oxygen and produce energy, and this may be the major site of age-related damage. This project seeks to understand the degree to which variation among these subcellular organelles affect free radical damage and aging, using the fruitfly Drosophila melanogaster as a model organism.Read moreRead less
How critical is the inflammatory response in senile plaque formation in a mutant APP transgenic mouse model? The aims of this project is to examine the brains of mice genetically engineered to produce a human mutant form of insoluble beta amyloid protein known to play a critical role in the development of Alzheimer's disease (AD). If the "trigger" for AD is an inflammatory reaction, then the relevant examination of the early stages of senile plaque formation in these animals could lead to pharma ....How critical is the inflammatory response in senile plaque formation in a mutant APP transgenic mouse model? The aims of this project is to examine the brains of mice genetically engineered to produce a human mutant form of insoluble beta amyloid protein known to play a critical role in the development of Alzheimer's disease (AD). If the "trigger" for AD is an inflammatory reaction, then the relevant examination of the early stages of senile plaque formation in these animals could lead to pharmaceutical intervention to delay the development of this debilitating disease. A 5 year delay would significantly reduce the number of people with AD, not only adding years of improved quality of life, but also saving hundreds of millions of Australian dollars in health costs.Read moreRead less
From Suspician to Intervention : Improving responsiveness to abuse of the elderly in acute and sub-acute health care. Early identification of risk and an integrated multidisciplinary response across the health service would be effective in responding to the multiple and complex behavioural and social issues which contribute to aged abuse as it presents in emergency, acute and sub-acute care, but are currently often ignored in health services and the literature. We propose that effective use of ....From Suspician to Intervention : Improving responsiveness to abuse of the elderly in acute and sub-acute health care. Early identification of risk and an integrated multidisciplinary response across the health service would be effective in responding to the multiple and complex behavioural and social issues which contribute to aged abuse as it presents in emergency, acute and sub-acute care, but are currently often ignored in health services and the literature. We propose that effective use of this "window of opportunity in health care" could extend the level of community response to this vulnerable group of people. Read moreRead less
Plasma protein profiles in normal brain ageing and early stages of dementia. Brain changes related to ageing and dementia are associated with altered proteins that can be detected in the blood. This project will examine blood samples from a number of well-characterised ageing cohorts to discover proteins that may serve as potential markers of brain ageing and the early stages of dementia.