Quantitative Metagenomics. This project aims to revolutionize our view of the microbial world once more by transforming microbiome studies from relative counts of organisms to actual numbers of microbes. This project expects to impact all the microbiome studies that are being performed worldwide by unveiling the actual numbers of microbes. Expected outcomes of this project include new techniques to enumerate the number of bacteria in different environments and new approaches to measure gene expr ....Quantitative Metagenomics. This project aims to revolutionize our view of the microbial world once more by transforming microbiome studies from relative counts of organisms to actual numbers of microbes. This project expects to impact all the microbiome studies that are being performed worldwide by unveiling the actual numbers of microbes. Expected outcomes of this project include new techniques to enumerate the number of bacteria in different environments and new approaches to measure gene expression within individual bacteria in any environment that will be demonstrated with complex microbial communities. This should provide significant benefits because microbes affect every aspect of our lives and those effects are driven by how many microbes are present.Read moreRead less
Phenotypic profiling from DNA using genetic and epigenetic information. The project intends to quantify how much information about a person can be inferred from a DNA sample. A DNA sample contains epigenomic information additional to the genome sequence. This information can reflect age and the past and present lifestyle of the individual whose sample it is. The project aims to quantify the accuracy of lifestyle and phenotypic prediction from DNA. Existing genome-wide genotype and methylation ar ....Phenotypic profiling from DNA using genetic and epigenetic information. The project intends to quantify how much information about a person can be inferred from a DNA sample. A DNA sample contains epigenomic information additional to the genome sequence. This information can reflect age and the past and present lifestyle of the individual whose sample it is. The project aims to quantify the accuracy of lifestyle and phenotypic prediction from DNA. Existing genome-wide genotype and methylation array data from thousands of blood samples from human subjects will be statistically analysed to develop and validate predictors for chronological age, smoking, caffeine use, pesticide exposure, diet and body mass index. Potential applications of epigenomic prediction are widespread, ranging from forensics to ecology.Read moreRead less
Genomics and evolution of symbiont transmission in coral reefs. This project aims to understand more deeply the symbiosis between coral and the alga Symbiodinium that underpins the primary productivity, biodiversity and economic impacts of Australia's iconic Great Barrier Reef. Reef-building corals are sustained by symbiosis between the coral and the alga Symbiodinium, and breakdown of symbiosis under environmental stress leads to coral bleaching and death. This project aims to understand how ge ....Genomics and evolution of symbiont transmission in coral reefs. This project aims to understand more deeply the symbiosis between coral and the alga Symbiodinium that underpins the primary productivity, biodiversity and economic impacts of Australia's iconic Great Barrier Reef. Reef-building corals are sustained by symbiosis between the coral and the alga Symbiodinium, and breakdown of symbiosis under environmental stress leads to coral bleaching and death. This project aims to understand how genomes of differently acquired Symbiodinium have evolved to support symbiosis with corals, through sequencing of algal genomes of Symbiodinium. This knowledge will improve the precision in predicting change to inform decision-making strategies in the conservation and restoration of coral reefs.Read moreRead less
Symbiodinium: the evolutionary transition to coral reef symbiont. Coral reefs are sustained by symbiosis between the coral host and dinoflagellates of genus Symbiodinium. Breakdown of this symbiosis under environmental stress results in coral bleaching and eventual death. This project aims to understand how dinoflagellate genomes have evolved to support a symbiotic lifestyle. The project aims to sequence genomes of Symbiodinium from reef corals and other hosts, and two free-living relatives. Thi ....Symbiodinium: the evolutionary transition to coral reef symbiont. Coral reefs are sustained by symbiosis between the coral host and dinoflagellates of genus Symbiodinium. Breakdown of this symbiosis under environmental stress results in coral bleaching and eventual death. This project aims to understand how dinoflagellate genomes have evolved to support a symbiotic lifestyle. The project aims to sequence genomes of Symbiodinium from reef corals and other hosts, and two free-living relatives. This should enable the identification of genes that have been gained or lost, or are under adaptive selection. This genome-scale perspective on the molecular systems implicated in the evolution of this symbiotic lifestyle has potential to inform strategies for preserving Australia's Great Barrier Reef in the face of climate variations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100234
Funder
Australian Research Council
Funding Amount
$430,000.00
Summary
Enhancement of South Australian high-performance computing facilities. These facilities will enable the efficient use of high-performance computing and will more than double the capability provided by eResearch SA for South Australian researchers. They will support large-scale applications, running over many processors in parallel (high-performance computing) or large numbers of single processors (high-throughput computing).