Investigating Deregulation Of Mitosis As A Mechanism Of Tumourigenesis In MYCN-driven Neuroblastoma
Funder
National Health and Medical Research Council
Funding Amount
$372,298.00
Summary
Neuroblastoma chemotherapy often only works temporarily because a small number of tumour cells can resist drugs and eventually regrow as a new tumour. These resistant cells resemble the very first cells that turn into a cancer cell at tumour initiation. We have used single cell technology to uncover genetic markers of tumour initiating cells. In this project we will determine how these marker genes cause tumour initiation and develop therapies that target them in drug resistant neuroblastoma.
Defining Biomarkers Of Colorectal Cancer Prevention By Dietary Agents And Translation To Human Intervention Studies
Funder
National Health and Medical Research Council
Funding Amount
$632,924.00
Summary
This research will explore dietary agents for their ability to regulate the damage to DNA that is responsible for causing bowel cancer. The plan is to identify a dietary approach that will effectively reduce the risk of colon cancer. The science will be tested in animal models followed by initial human experiments aimed at testing the relevance to humans.