Harnessing Multiple Large Datasets To Answer Critical Questions On Diabetes Epidemiology
Funder
National Health and Medical Research Council
Funding Amount
$631,370.00
Summary
This proposal will examine novel causes and consequences of diabetes using three approaches. Firstly, it will examine diabetes trends. Secondly, it will use the Australian Diabetes Registry linked to several key government database to explore important research questions, related to diabetes treatment, dementia and endstage kidney disease, which previously were not able to be answered. Thirdly, it will examine the role of environmental pollutants in the development of chronic disease.
CLOSING THE GAP IN EARLY DIAGNOSTIC CAPABILITIES FOR MYCOSES - DNA BARCODING TO COMBAT AN EMERGING GLOBAL HEALTH PROBLEM
Funder
National Health and Medical Research Council
Funding Amount
$753,447.00
Summary
Fungal infections are a major health threat with high mortality and costs. Fast identification of a causative agent is required to initiate correct treatment to maximise disease outcome. Short DNA sequences – DNA barcodes – offer a fast accurate identification. This grant sets out to establish a dual-locus barcode scheme, build a reference database, adapt the scheme to new sequencing technologies and to facilitate sequence-based fungal identification in the routine diagnostic laboratory.
Dnmt3L Haploinsufficent Retrotransposition Leads To Genetic Hypermutation
Funder
National Health and Medical Research Council
Funding Amount
$613,982.00
Summary
This project aims to demonstrate the critical importance of DNA methylation as a cause of mutation and thus genetic diseases, many instances of sterility and low fertility, and cancers. Because DNA methylation can be partially determined by substrate availability, a demonstration of the importance of DNA methylation vis a vis mutation rates will refine our understanding of the impact of metabolism and nutrition on mutation rate as a cause of human disease.
An Indigenous Australian Reference Genome: Indigenous Inclusion In The Benefits Of Genomic Medicine
Funder
National Health and Medical Research Council
Funding Amount
$1,428,508.00
Summary
This project will establish an Indigenous Australian reference genome (the NCIGrg) within the National Centre for Indigenous Genomics (NCIG) using advanced genome sequencing technologies and data analytics and evaluate its research and clinical utility. The NCIGrg will be cornerstone of future genomic research and its clinical application in Indigenous communities. It will underpin NCIG’s commitment to ensuring that Indigenous Australians are included in the benefits of genomic medicine.
Evaluation Of An Online Injury Surveillance System In Community Sport
Funder
National Health and Medical Research Council
Funding Amount
$60,741.00
Summary
Despite high rates of injury, there is currently no way to accurately record injuries in community sport. To address this issue an online injury tracking system has been developed for community sports clubs. This research will test the utility of this system within community Australian football clubs and compare it with other injury recording methods. With better methods of injury recording, we will improve our understanding of injury risks. In turn, this information can be used to make sport sa ....Despite high rates of injury, there is currently no way to accurately record injuries in community sport. To address this issue an online injury tracking system has been developed for community sports clubs. This research will test the utility of this system within community Australian football clubs and compare it with other injury recording methods. With better methods of injury recording, we will improve our understanding of injury risks. In turn, this information can be used to make sport safer.Read moreRead less
Autoimmune Rheumatic Disease And Outcomes After Acute Myocardial Infarction
Funder
National Health and Medical Research Council
Funding Amount
$151,214.00
Summary
Patients with inflammatory arthritis have an increased risk of heart disease and may have worse outcomes after heart attack than the general population. This research project looks at the risk of death after heart attack in people with inflammatory arthritis. This project also compares the treatment that people with arthritis receive after a heart attack with the treatment provided to the general population.
Multiple Sclerosis (MS) is an autoimmune disease often diagnosed in early adulthood. Outcomes very enormously, from mild to disabling. This fellowship supports research to improve outcome prediction using genetics and to examine different strategies to optimise treatment outcomes and safety. The main data source is MSBase, which tracks over 31000 people with MS globally and is based in the University of Melbourne's brain Centre at the Royal Melbourne Hospital.