Rethinking housing: network analysis for digital collaboration. This project aims to understand persistent housing sector supply problems through analysis of digital collaborative practices. This project expects to generate new knowledge for an emerging housing digital economy using interdisciplinary network theory and data visualisation techniques. The housing sector has long been criticised for shortcomings in affordability, efficiency, quality, social and environmental responsiveness and appr ....Rethinking housing: network analysis for digital collaboration. This project aims to understand persistent housing sector supply problems through analysis of digital collaborative practices. This project expects to generate new knowledge for an emerging housing digital economy using interdisciplinary network theory and data visualisation techniques. The housing sector has long been criticised for shortcomings in affordability, efficiency, quality, social and environmental responsiveness and appropriateness of offerings. Expected outcomes include enhanced housing supply professionals' capability, improved knowledge among public/private sector decision makers responsible for housing supply and development of new digital collaborative behavioural theoretical and practical frameworks for the sector.Read moreRead less
Efficient construction: analysis of integrated supply chains for innovative off site housing manufacturing. The Australian housing industry is failing to meet demand. Housing construction is too slow, as indicated by a 40 per cent increase in average construction time over the last fifteen years. Industry fragmentation is an oft-cited cause of construction inefficiency. A solution is offsite manufacturing. Australia lags other countries in adoption of off-site manufacturing. To achieve adoption ....Efficient construction: analysis of integrated supply chains for innovative off site housing manufacturing. The Australian housing industry is failing to meet demand. Housing construction is too slow, as indicated by a 40 per cent increase in average construction time over the last fifteen years. Industry fragmentation is an oft-cited cause of construction inefficiency. A solution is offsite manufacturing. Australia lags other countries in adoption of off-site manufacturing. To achieve adoption and diffusion, fragmentation needs to be addressed. This project aims to analyse the factors affecting supply chain integration to support innovative offsite manufacturing and develop a novel collaborative practice based implementation model.Read moreRead less
Safe and healthy construction: the influence of clients in driving improvement through construction procurement and project management practices. The project will measure the impact that the construction industry's clients can exert over the workplace health and safety (WHS) performance of projects. The project will identify client actions that have a positive impact upon WHS and will help embed WHS management practices in the procurement of major infrastructure construction projects.
An experimental evaluation of the usefulness of computer-supported argumentation to improve occupational health and safety in construction design. The research investigates the potential for experts' occupational health and safety (OHS) reasoning to be reproduced in a knowledge-based system and used to: (i) augment the OHS decision-making of construction design professionals; and (ii) develop design OHS capability, especially in novices. The results will support the implementation of OHS policy ....An experimental evaluation of the usefulness of computer-supported argumentation to improve occupational health and safety in construction design. The research investigates the potential for experts' occupational health and safety (OHS) reasoning to be reproduced in a knowledge-based system and used to: (i) augment the OHS decision-making of construction design professionals; and (ii) develop design OHS capability, especially in novices. The results will support the implementation of OHS policy in the construction industry.Read moreRead less
Statistical Methods For Identifying Structural Variation In Tumour Genomes Using Next Generation Sequencing
Funder
National Health and Medical Research Council
Funding Amount
$243,458.00
Summary
New DNA sequencing technology can sequence a tumour genome affordably in 2 weeks. This re-sequencing data can be used to find small mutations and large-scale chromosomal rearrangements that together are the drivers of cancer. These may one day be used to guide cancer therapy. This project will develop new algorithms for finding mutations and apply these to discover the genetic basis of drug resistance in a model lymphoma system.
Maximising the value of alliances in delivering infrastructure projects: a mixed methods management study of procurement innovation. Australia’s new infrastructure is currently being delivered inefficiently. The project will take a novel approach to improving efficiency, focusing on cooperation within construction teams. The project will develop new mechanisms to align incentives and capabilities within construction teams.
Epigenetic regulation of genomic stability and inheritance. Sperm mediate inheritance by transmitting DNA and associated chemical (epigenetic) modifications to offspring. We hypothesise that epigenetic modifications protect DNA from mutations during sperm formation. Using innovative models, our interdisciplinary team will determine whether loss of specific epigenetic modifications permits mutations in sperm and whether these mutations are transmitted to offspring. Our work will contribute to und ....Epigenetic regulation of genomic stability and inheritance. Sperm mediate inheritance by transmitting DNA and associated chemical (epigenetic) modifications to offspring. We hypothesise that epigenetic modifications protect DNA from mutations during sperm formation. Using innovative models, our interdisciplinary team will determine whether loss of specific epigenetic modifications permits mutations in sperm and whether these mutations are transmitted to offspring. Our work will contribute to understanding how new mutations arise in sperm and potentially affect offspring phenotype, adaptation and evolution. As chemicals, drugs and diet can affect epigenetic function, our studies will also contribute to determining how epigenetic inheritance affects environmental, agricultural and healthcare outcomes.Read moreRead less
Greening procurement of infrastructure construction: optimising mass-haul operations to reduce greenhouse gas emissions. This project will develop and prototype tools to reduce the high environmental impact of mass haul operations in road and rail infrastructure projects. Both contractors and clients need practical methods for calculating, optimising and procuring optimal solutions, because mass haul is one of the few areas where a contractor can reduce carbon dioxide impact.
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Reducing youth unemployment through social procurement in construction. This project aims to produce new conceptual insights into effective cross-sector collaboration in construction, in order to provide solutions to address youth unemployment. Youth unemployment is a significant economic, social and health problem. Yet Australia’s largest youth employer, the construction industry, faces skills shortages to deliver an unprecedented construction and infrastructure pipeline. Social procurement is ....Reducing youth unemployment through social procurement in construction. This project aims to produce new conceptual insights into effective cross-sector collaboration in construction, in order to provide solutions to address youth unemployment. Youth unemployment is a significant economic, social and health problem. Yet Australia’s largest youth employer, the construction industry, faces skills shortages to deliver an unprecedented construction and infrastructure pipeline. Social procurement is a potential solution to both these challenges but requires new approaches to cross sector collaborations. This project aims to develop new insights, practical knowledge and practical tools for effective social procurement.Read moreRead less