Rethinking housing: network analysis for digital collaboration. This project aims to understand persistent housing sector supply problems through analysis of digital collaborative practices. This project expects to generate new knowledge for an emerging housing digital economy using interdisciplinary network theory and data visualisation techniques. The housing sector has long been criticised for shortcomings in affordability, efficiency, quality, social and environmental responsiveness and appr ....Rethinking housing: network analysis for digital collaboration. This project aims to understand persistent housing sector supply problems through analysis of digital collaborative practices. This project expects to generate new knowledge for an emerging housing digital economy using interdisciplinary network theory and data visualisation techniques. The housing sector has long been criticised for shortcomings in affordability, efficiency, quality, social and environmental responsiveness and appropriateness of offerings. Expected outcomes include enhanced housing supply professionals' capability, improved knowledge among public/private sector decision makers responsible for housing supply and development of new digital collaborative behavioural theoretical and practical frameworks for the sector.Read moreRead less
Efficient construction: analysis of integrated supply chains for innovative off site housing manufacturing. The Australian housing industry is failing to meet demand. Housing construction is too slow, as indicated by a 40 per cent increase in average construction time over the last fifteen years. Industry fragmentation is an oft-cited cause of construction inefficiency. A solution is offsite manufacturing. Australia lags other countries in adoption of off-site manufacturing. To achieve adoption ....Efficient construction: analysis of integrated supply chains for innovative off site housing manufacturing. The Australian housing industry is failing to meet demand. Housing construction is too slow, as indicated by a 40 per cent increase in average construction time over the last fifteen years. Industry fragmentation is an oft-cited cause of construction inefficiency. A solution is offsite manufacturing. Australia lags other countries in adoption of off-site manufacturing. To achieve adoption and diffusion, fragmentation needs to be addressed. This project aims to analyse the factors affecting supply chain integration to support innovative offsite manufacturing and develop a novel collaborative practice based implementation model.Read moreRead less
Constructing Building Integrity: Raising standards through professionalism. This project aims to investigate the role of professions in rebuilding trust in residential building construction in Australia. In the wake of expensive and life-threatening building defects, this project expects to generate new knowledge about the functioning of individual professionals, professionals employed in multi-profession organisations, and professionals’ interaction with their institutional environment. Expecte ....Constructing Building Integrity: Raising standards through professionalism. This project aims to investigate the role of professions in rebuilding trust in residential building construction in Australia. In the wake of expensive and life-threatening building defects, this project expects to generate new knowledge about the functioning of individual professionals, professionals employed in multi-profession organisations, and professionals’ interaction with their institutional environment. Expected outcomes include practical recommendations for improved professional standards, a rigorous building integrity system and a means for measuring change. Anticipated benefits include greater awareness by professions, trades and regulators of their role in in delivering the public goods of a trustworthy construction industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775503
Funder
Australian Research Council
Funding Amount
$255,000.00
Summary
Robotics for plant genomics: Increasing throughput in plant genetic analyses. Plant genomics has direct benefit to crop improvement, especially as focussed in the applicants' laboratories. Thus, the Australian agri-food sector will benefit substantially from the acceleration in plant functional genomics that will arise from the installation of the robotics equipment described in the current application, by both underpinning more applied research and also being used directly in crop improvement p ....Robotics for plant genomics: Increasing throughput in plant genetic analyses. Plant genomics has direct benefit to crop improvement, especially as focussed in the applicants' laboratories. Thus, the Australian agri-food sector will benefit substantially from the acceleration in plant functional genomics that will arise from the installation of the robotics equipment described in the current application, by both underpinning more applied research and also being used directly in crop improvement programs such as are based at the Waite Campus. The outputs will include crops with increased tolerance to biotic and abiotic stresses, a reduced dependence on chemical inputs such as fertilisers and improved food quality, with consequent benefits to the environment and human health and nutrition.Read moreRead less
Identification of Biological pathways regulated by circular RNAs. Circular RNAs (circRNAs) are a, recently discovered molecule. circRNAs are highly abundant and expressed in a tissue and disease specific manner. Yet, currently the understanding of how circRNAs regulate biological processes is very poor. This project aims to use pooled shRNA libraries to screen a large panel of cell lines and systematically identify cellular activities that are regulated by circRNAs. The expected outcome of this ....Identification of Biological pathways regulated by circular RNAs. Circular RNAs (circRNAs) are a, recently discovered molecule. circRNAs are highly abundant and expressed in a tissue and disease specific manner. Yet, currently the understanding of how circRNAs regulate biological processes is very poor. This project aims to use pooled shRNA libraries to screen a large panel of cell lines and systematically identify cellular activities that are regulated by circRNAs. The expected outcome of this study will be a catalogue of functionally active circRNAs. Over the past decades, the wealth of knowledge on the function of linear mRNAs has had a significant impact on medicine and agriculture. Similarly understanding how circRNAs regulate cellular activities may have an analogous impact on humans.Read moreRead less
Spatio-temporal activation of genes in cells and mice. This project aims to develop novel genetic methods and instrumentation for the local, rapid and reversible activation of genes in cells and mice. This project expects to generate highly innovative light- and sound-based technologies that will permit to study living systems on the gene-level with unprecedented precision. Expected outcomes include new research and technology capacity to broadly address fundamental biological questions and to c ....Spatio-temporal activation of genes in cells and mice. This project aims to develop novel genetic methods and instrumentation for the local, rapid and reversible activation of genes in cells and mice. This project expects to generate highly innovative light- and sound-based technologies that will permit to study living systems on the gene-level with unprecedented precision. Expected outcomes include new research and technology capacity to broadly address fundamental biological questions and to create new applied processes. This project intends to provide significant benefits, such as enhanced knowledge generation, multidisciplinary training opportunities and patentable technologies.Read moreRead less
HEN1 is a regulator of piRNA metabolism, transcriptional regulation and mammalian male fertility. This project is to define the biochemistry of a previously uncharacterized protein in male fertility using a unique mouse model and innovative DNA and protein technologies. This project will define a novel, and essential, pathway for male fertility and may ultimately have relevance to the maintenance of health or improving fertility.
Transcription factor nuclear residency as a driver of gene expression. Persistently active proteins can stay in the nucleus to drive cell growth and prevent cell death. This project will define how one specific active protein can remain in the nucleus and regulate gene expression through the action of unique ribonucleic acid (RNA) molecules. The results will enable persistent gene activation to be manipulated in cancer.
Unveiling the epigenome dynamics through the pluripotency continuum. This project aims to utilise stem cells and genomics based technologies, in combination with new computational algorithms to dissect the fundamental molecular events that drive the first steps during development. The project is expected to unveil the basic mechanisms underpinning how genes driving the developmental master plan are controlled in cells that have the capacity to give rise to the whole organism and placenta. The kn ....Unveiling the epigenome dynamics through the pluripotency continuum. This project aims to utilise stem cells and genomics based technologies, in combination with new computational algorithms to dissect the fundamental molecular events that drive the first steps during development. The project is expected to unveil the basic mechanisms underpinning how genes driving the developmental master plan are controlled in cells that have the capacity to give rise to the whole organism and placenta. The knowledge gained from this work will inform and guide future novel approaches, such as in assisted reproductive technologies or regenerative medicine.Read moreRead less
Control points in nitrogen uptake: enhancing the response of cereals to nitrogen supply and demand. Vast amounts of nitrogen fertiliser are applied to cereal crops to maintain yields. By uncovering what limits nitrogen uptake in cereals, this project will provide the scientific basis for improving nitrogen use efficiency and decreasing fertiliser use, with significant economic and environmental benefits.