Rethinking housing: network analysis for digital collaboration. This project aims to understand persistent housing sector supply problems through analysis of digital collaborative practices. This project expects to generate new knowledge for an emerging housing digital economy using interdisciplinary network theory and data visualisation techniques. The housing sector has long been criticised for shortcomings in affordability, efficiency, quality, social and environmental responsiveness and appr ....Rethinking housing: network analysis for digital collaboration. This project aims to understand persistent housing sector supply problems through analysis of digital collaborative practices. This project expects to generate new knowledge for an emerging housing digital economy using interdisciplinary network theory and data visualisation techniques. The housing sector has long been criticised for shortcomings in affordability, efficiency, quality, social and environmental responsiveness and appropriateness of offerings. Expected outcomes include enhanced housing supply professionals' capability, improved knowledge among public/private sector decision makers responsible for housing supply and development of new digital collaborative behavioural theoretical and practical frameworks for the sector.Read moreRead less
Efficient construction: analysis of integrated supply chains for innovative off site housing manufacturing. The Australian housing industry is failing to meet demand. Housing construction is too slow, as indicated by a 40 per cent increase in average construction time over the last fifteen years. Industry fragmentation is an oft-cited cause of construction inefficiency. A solution is offsite manufacturing. Australia lags other countries in adoption of off-site manufacturing. To achieve adoption ....Efficient construction: analysis of integrated supply chains for innovative off site housing manufacturing. The Australian housing industry is failing to meet demand. Housing construction is too slow, as indicated by a 40 per cent increase in average construction time over the last fifteen years. Industry fragmentation is an oft-cited cause of construction inefficiency. A solution is offsite manufacturing. Australia lags other countries in adoption of off-site manufacturing. To achieve adoption and diffusion, fragmentation needs to be addressed. This project aims to analyse the factors affecting supply chain integration to support innovative offsite manufacturing and develop a novel collaborative practice based implementation model.Read moreRead less
Greening procurement of infrastructure construction: optimising mass-haul operations to reduce greenhouse gas emissions. This project will develop and prototype tools to reduce the high environmental impact of mass haul operations in road and rail infrastructure projects. Both contractors and clients need practical methods for calculating, optimising and procuring optimal solutions, because mass haul is one of the few areas where a contractor can reduce carbon dioxide impact.
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Reducing youth unemployment through social procurement in construction. This project aims to produce new conceptual insights into effective cross-sector collaboration in construction, in order to provide solutions to address youth unemployment. Youth unemployment is a significant economic, social and health problem. Yet Australia’s largest youth employer, the construction industry, faces skills shortages to deliver an unprecedented construction and infrastructure pipeline. Social procurement is ....Reducing youth unemployment through social procurement in construction. This project aims to produce new conceptual insights into effective cross-sector collaboration in construction, in order to provide solutions to address youth unemployment. Youth unemployment is a significant economic, social and health problem. Yet Australia’s largest youth employer, the construction industry, faces skills shortages to deliver an unprecedented construction and infrastructure pipeline. Social procurement is a potential solution to both these challenges but requires new approaches to cross sector collaborations. This project aims to develop new insights, practical knowledge and practical tools for effective social procurement.Read moreRead less
Transcription factors find their targets by reading the epigenetic code. This project aims to elucidate how transcription factors, proteins that regulate gene expression, find their target genes. The hypothesis is that non-DNA binding domains play an essential role in this process. This project expects to transform our understanding of transcription factor families, and how factors in families with the same DNA-binding domain manage to regulate different genes. Expected outcomes of this project ....Transcription factors find their targets by reading the epigenetic code. This project aims to elucidate how transcription factors, proteins that regulate gene expression, find their target genes. The hypothesis is that non-DNA binding domains play an essential role in this process. This project expects to transform our understanding of transcription factor families, and how factors in families with the same DNA-binding domain manage to regulate different genes. Expected outcomes of this project include revealing how accessory proteins help transcription factors identify their targets in the genome by reading epigenetic marks. This should provide significant benefits including improved design of artificial transcription factors to up- or down-regulate specific genes in research and agriculture.Read moreRead less
Improving the Environmental Performance of Australian Construction Projects. This project aims to investigate the environmental impacts of construction in Australia through the development of a sophisticated hybrid environmental assessment model. The project aims to assist in identifying the most significant environmental impacts, critical areas for mitigation efforts and informing environmental policy and programs within the Australian construction industry. The development of one of the most s ....Improving the Environmental Performance of Australian Construction Projects. This project aims to investigate the environmental impacts of construction in Australia through the development of a sophisticated hybrid environmental assessment model. The project aims to assist in identifying the most significant environmental impacts, critical areas for mitigation efforts and informing environmental policy and programs within the Australian construction industry. The development of one of the most sophisticated and comprehensive models for assessing environmental impacts ever produced is expected to enable cost- and time-efficient evaluation of multiple environmental impacts at a high level of detail and completeness. This should lead to considerable improvements to the environmental performance of Australian construction projects.Read moreRead less
Designer DNA-binding factors. This project aims to use a natural transcription factor family to enhance the efficiency and functionality of designer DNA-binding factors. Research into the structure and function of zinc finger transcription factors, TAL effectors and CRISPR created designer DNA-binding factors. However, though research has improved the specificity of these factors’ genome-wide binding, their efficacy in regulating the expression of genes requires improvement. Using sequencing, th ....Designer DNA-binding factors. This project aims to use a natural transcription factor family to enhance the efficiency and functionality of designer DNA-binding factors. Research into the structure and function of zinc finger transcription factors, TAL effectors and CRISPR created designer DNA-binding factors. However, though research has improved the specificity of these factors’ genome-wide binding, their efficacy in regulating the expression of genes requires improvement. Using sequencing, the project intends to enhance the efficiency and function of these factors by designing modules to improve the stability of DNA binding and effectiveness in functionally regulating gene expression. The project outcomes could include knowledge enabling the use of genetically engineered DNA-binding proteins to artificially control gene expression, with significant scientific and economic implications.Read moreRead less
Genetic, Cellular and Molecular Analysis of Cardiac Ventricular Septation. The project aims to define the blueprint for ventricular septation in the mammalian heart – how, during heart development, a single ventricle becomes divided in two by a muscular wall, thus creating left and right pumps and electrical circuits serving the body and lung circulations separately. A proprietary mouse genetic model was created and will be used to probe the cellular and molecular mechanisms of septation using n ....Genetic, Cellular and Molecular Analysis of Cardiac Ventricular Septation. The project aims to define the blueprint for ventricular septation in the mammalian heart – how, during heart development, a single ventricle becomes divided in two by a muscular wall, thus creating left and right pumps and electrical circuits serving the body and lung circulations separately. A proprietary mouse genetic model was created and will be used to probe the cellular and molecular mechanisms of septation using new technologies able to resolve biology at a single-cell level. Outcomes may include new knowledge on heart development and evolution, including how the cardiac electrical system is formed, and how cell boundaries and tissue complexity are generated. The project may advance new technologies and create new data resources.Read moreRead less
Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a ....Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.Read moreRead less