Exploring genetic diversity to identify new heat tolerance genes in wheat. This project aims to improve the selection and development of heat-tolerant wheat varieties. Heatwaves seriously reduce wheat yields worldwide, and the situation will worsen with climate variation. This project aims to apply a broad genetic scan to identify the main chromosome regions controlling heat tolerance at the sensitive flowering stage in Australian and European wheat varieties. It is expected that this knowledge ....Exploring genetic diversity to identify new heat tolerance genes in wheat. This project aims to improve the selection and development of heat-tolerant wheat varieties. Heatwaves seriously reduce wheat yields worldwide, and the situation will worsen with climate variation. This project aims to apply a broad genetic scan to identify the main chromosome regions controlling heat tolerance at the sensitive flowering stage in Australian and European wheat varieties. It is expected that this knowledge will deliver crucial breeders’ tools to select heat-tolerant varieties. The project also aims to identify genes most likely to control tolerance at these chromosome locations using gene expression profiling data, trait associations and knowledge of heat-tolerance genes from other species. It is expected that these genes will reveal molecular mechanisms of heat tolerance and create new opportunities to engineer superior levels of tolerance in cereals.Read moreRead less
Genome-wide determination of Puccinia psidii s.l. rust resistance in eucalypts. Recently, guava rust was detected in Australia, posing significant risks to native flora, plantations, and timber exports. Scientists from The University of Melbourne and Victorian Department of Primary Industries together with tree breeders, forest growers and forest managers aim to use tree genomics rust resistance breeding to enable management and operational responses and inform policy development.
Fertility crisis: harnessing the genomic tension behind pollen fertility in sorghum. Hybrid sorghum varieties yield more grain than inbred varieties but the production seed for farmers can be difficult. This project will identify the genes responsible for a trait that makes hybrid seed production possible and this knowledge will help raise sorghum yields in Australian and in some of the world’s poorest countries.
Development of molecular markers for resistance to blackleg disease (Leptosphaeria maculans) in canola. Canola (Brassica napus) is a valuable oil seed crop grown in many parts of the world and contributes annually $A450 million to the Australian economy. The overall aim of this project is to develop molecular markers for blackleg resistance using Australian germplasm along with evaluation in Australian disease nurseries which are regarded worlwide to develop the highest levels of disease pressu ....Development of molecular markers for resistance to blackleg disease (Leptosphaeria maculans) in canola. Canola (Brassica napus) is a valuable oil seed crop grown in many parts of the world and contributes annually $A450 million to the Australian economy. The overall aim of this project is to develop molecular markers for blackleg resistance using Australian germplasm along with evaluation in Australian disease nurseries which are regarded worlwide to develop the highest levels of disease pressure. Once molecular marker systems are developed and evaluated, they will be applied to facilitate the selection of Nugrain's (Industry Partner) canola breeding programs. Any molecular markers and QTL developed for Australian cultivars would find commercial application in breeding programmes.Read moreRead less
Methods to infer dense genomic information from sparsely genotyped populations. Prediction of phenotype based on DNA polymorphisms or sequence has important applications such as prediction of disease risk in human medicine and prediction of genetic value in plant or animal breeding. This project will enhance precision and lower the cost of association studies leading to substantial increase in accuracy of such predictions. This will allow more effective genetic improvement, particularly of diff ....Methods to infer dense genomic information from sparsely genotyped populations. Prediction of phenotype based on DNA polymorphisms or sequence has important applications such as prediction of disease risk in human medicine and prediction of genetic value in plant or animal breeding. This project will enhance precision and lower the cost of association studies leading to substantial increase in accuracy of such predictions. This will allow more effective genetic improvement, particularly of difficult but important traits such as disease resistance, reduced green-house gas emissions and product quality. The same methods can be extended to improve genetic improvement in plants and better prediction of human disease risk. Read moreRead less
Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a ....Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.Read moreRead less
Bayesian methodology for analysis of genome data with focus on the livestock industry. The aim is to develop statistical methods for the design and analysis of genome data with focus on the special needs of the livestock industry. This will significantly contribute to profitability, quality, genetic improvement and genetic knowledge in a key national industry, improve Australia's international and national profile in the key research area of bioinformatics, and encourage optimisation of current ....Bayesian methodology for analysis of genome data with focus on the livestock industry. The aim is to develop statistical methods for the design and analysis of genome data with focus on the special needs of the livestock industry. This will significantly contribute to profitability, quality, genetic improvement and genetic knowledge in a key national industry, improve Australia's international and national profile in the key research area of bioinformatics, and encourage optimisation of current information. Outcomes include a toolkit of applicable statistical methods, statistically valid algorithms, marketable methods for gene discovery, technology transfer, training and publications.Read moreRead less
Brassica genome organisation and evolution: unlocking the potential of using genome-specific repetitive elements for crop improvement. Introgression of chromosome segments from related Brassica species provides an opportunity to develop locally adapted varieties with improved agronomic and quality traits. There is a need to understand Brassica genome organisation and how this information can be used for enhancing the efficiency of cultivar development. Dispersed and tandem repetitive DNA sequen ....Brassica genome organisation and evolution: unlocking the potential of using genome-specific repetitive elements for crop improvement. Introgression of chromosome segments from related Brassica species provides an opportunity to develop locally adapted varieties with improved agronomic and quality traits. There is a need to understand Brassica genome organisation and how this information can be used for enhancing the efficiency of cultivar development. Dispersed and tandem repetitive DNA sequences provide valuable information on the organisation and evolution of plant chromosomes. Methods for monitoring chromosome segment transfer across Brassica species will be developed based on detecting and quantifying genome-specific repetitive DNA sequences. Australian Brassica improvement programs could benefit from this research by adopting methods to detect chromosome segment transfer during interspecific hybridisation.Read moreRead less
Identification of Traits and Function by Genomic Matching. Differences between individuals are largely inherited and therefore encoded within the DNA. The challenge is to develop practical means of detecting these differences irrespective of whether they are observable as a phenotype.
Here we focus on livestock. For example, most Australian cattle are horned rather than polled. The inheritance is relatively simple but there is still no DNA test to detect the recessive horning gene.
T ....Identification of Traits and Function by Genomic Matching. Differences between individuals are largely inherited and therefore encoded within the DNA. The challenge is to develop practical means of detecting these differences irrespective of whether they are observable as a phenotype.
Here we focus on livestock. For example, most Australian cattle are horned rather than polled. The inheritance is relatively simple but there is still no DNA test to detect the recessive horning gene.
The genomic matching technique is an in-house patented procedure for identifying such DNA differences. If successful, our test will assist industry to eliminate horning and thereby painful dehorning whilst reducing damage to workers and product.
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Exploiting the Arabidopsis genome sequence as a molecular 'toolbox' for Brassica improvement. Australia's position as a major exporter of canola (Brassica napus) is under threat from genetic improvements in yield and quality being made by our international competitors. We will identify genes from Arabidopsis (the 'tool-box') that will be used to increase the speed of selection of new canola varieties with improved oleic acid content, disease resistance, and agronomic traits such as early flower ....Exploiting the Arabidopsis genome sequence as a molecular 'toolbox' for Brassica improvement. Australia's position as a major exporter of canola (Brassica napus) is under threat from genetic improvements in yield and quality being made by our international competitors. We will identify genes from Arabidopsis (the 'tool-box') that will be used to increase the speed of selection of new canola varieties with improved oleic acid content, disease resistance, and agronomic traits such as early flowering and cold tolerance. Genome similarity between Arabidopsis and canola will be exploited to map specific genes from Arabidopsis directly into canola. Based on this knowledge, we will develop gene-specific molecular markers for rapid selection of Australian-adapted canola varieties.Read moreRead less