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Optic Nerve Head Structure And Genetic/environmental Associations: A Population-based SD-OCT Study
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
My research project combines two powerful new technologies, spectral domain-optical coherence tomography and the genome-wide association study, to investigate the physical and genetic characteristics of the optic nerve head in humans. Results from this work will help identify new glaucoma risk genes, increasing sensitivity and specificity for predicting glaucoma and expand our understanding of the disease mechanism allowing for the development of new treatments.
The Role Of Gastric Vagal Afferents In The Food Intake Reducing Effect Of Oestradiol
Funder
National Health and Medical Research Council
Funding Amount
$317,739.00
Summary
Regulation of food intake is paramount for maintaining health. Nerves from the stomach serve as important regulators of food intake. These nerves can be modulated by chemical substances; however the importance of this modulation is not well defined. The sex steroid, oestradiol, has potent food intake reducing effects, but the mechanism for this is poorly understood. Thus, this fellowship will examine the role that oestradiol has in regulating food intake by acting on nerves within the stomach.
The Role Of The Systemic Milieu In Preventing Motor Unit Remodelling And Loss During Ageing
Funder
National Health and Medical Research Council
Summary
Motor unit remodeling and loss contributes to the decline in muscle mass, strength and quality of life in our aging population. Recent data shows that exposing aged mice to 'blood-borne factors' from the circulation of a young mouse can reverse the age-associated deficits in motor unit structure and function. A better understanding of the factors controlling these anti-aging effects will be vital for finding new compounds to reverse the aging process and improve quality of life.
A Comparative Study Between The Effects Of C-terminally Truncated A-synuclein Metabolites And Full Length A-synuclein In Aged Rat Hippocampal Neurons
Funder
National Health and Medical Research Council
Funding Amount
$231,284.00
Summary
I am a neurologist from Xi�an Jiaotong University, China. My major research interest is in neurodegenerative diseases, especially Parkinson and Alzheimer�s disease. I enter this field because I know ageing population will have an enormous impact on the world�s economy. I started collaboration with Dr. Weiping Gai in Flinders University. We are interested in the toxic effects of both a-synuclein and its metabolites, their mechanisms and ways to block them.
Mechanisms Of Ion Channel Dysfunction In Hereditary And Acquired Neuropathies
Funder
National Health and Medical Research Council
Funding Amount
$404,869.00
Summary
Nerve function is dependent on ion channels, which provide the basis for neurotransmission. Inherited or acquired abnormalities in ion channel function are important in diseases including epilepsy, pain disorders, neuromuscular diseases and toxic neuropathy. This project will use a combination of techniques to study mechanisms underlying nerve dysfunction to compare genetic nerve problems and acquired nerve damage to understand how damage occurs and develop new therapies and diagnostic tests.
Aberrant Nerve Excitability: An In-depth Study Of HCN Channel Activity In Neurological Disorders (epilepsy And Chronic Neuropathic Pain).
Funder
National Health and Medical Research Council
Funding Amount
$205,315.00
Summary
Chronic neuropathic pain and epilepsy carry a high burden of disease, and have a major impact on health resources. Abnormal nerve excitability is implicated in both conditions. This study evaluates the use of a non-invasive test applied to peripheral nerve in the measurement of nerve excitability in neuropathic pain and epilepsy. The aim is to establish a sensitive biomarker of disease in assessment and diagnosis of patients, and to help direct therapy and measure response to treatment.
The Contribution Of IL-1 Signalling To Long-term Neurodegeneration, Epilepsy And Neurocognitive Outcomes Following Traumatic Injury To The Paediatric Brain
Funder
National Health and Medical Research Council
Funding Amount
$394,670.00
Summary
Epilepsy is a common, debilitating consequence of brain injury in children, however little is known about factors which trigger its development. This proposal investigates the contribution of the acute inflammatory response to long-term neuronal loss, functional outcomes and seizure activity after paediatric brain injury. Understanding how epilepsy and brain damage progresses after injury will aid the development of drugs to improve long-term outcomes in brain-injured children.