Sensory Neuronal Pathways From The Lower Genital Tract Of Females
Funder
National Health and Medical Research Council
Funding Amount
$397,224.00
Summary
Many women experience severe debilitating pain upon normally innocuous contact with their genitalia. The causes of this pain are unknown. Therefore, this project will use a suite of sophisticated microscopic and electrical recording techniques to identify the neural pathways that transmit sensation, including pain, from the female lower genital tract. Our new data will help create a rational basis for understanding and treating the physical basis of genital pain in women.
Interactions Between Herpes Simplex Viral And Neuronal Motor Proteins
Funder
National Health and Medical Research Council
Funding Amount
$222,962.00
Summary
Herpes simplex virus (HSV) lies dormant within the nerve cell bodies near the spinal cord in most people. Intermittently the virus reactivates and is transported down the nerve to the skin where it causes blisters-ulcers or is shed without causing symptoms. The aim of this grant is to determine how Herpes Simplex virus is transported within nerve cells at the molecular level. It builds on recent discoveries of a direct interaction between a Herpes simplex viral protein and the nerve cell motor p ....Herpes simplex virus (HSV) lies dormant within the nerve cell bodies near the spinal cord in most people. Intermittently the virus reactivates and is transported down the nerve to the skin where it causes blisters-ulcers or is shed without causing symptoms. The aim of this grant is to determine how Herpes Simplex virus is transported within nerve cells at the molecular level. It builds on recent discoveries of a direct interaction between a Herpes simplex viral protein and the nerve cell motor protein which transports essential components down nerves from the spinal cord to the skin. Ultimately we aim to develop inhibitors of this process which might be candidates for further development as antivirals for control of recurrent herpes simplex.Read moreRead less