Discrete particle simulation of powder dispersion in pharmaceutical aerosol inhalers. A successful completion of the project will i) greatly enhance the Australian R&D profile and capabilities of both computational modelling and pharmaceutical aerosol research in the world; ii) provide an improved delivery of therapeutic dose to patients via inhalers with better performance to enhance the therapeutic benefits; iii) enable wide availability of inexpensive and effective pharmaceutical inhalation p ....Discrete particle simulation of powder dispersion in pharmaceutical aerosol inhalers. A successful completion of the project will i) greatly enhance the Australian R&D profile and capabilities of both computational modelling and pharmaceutical aerosol research in the world; ii) provide an improved delivery of therapeutic dose to patients via inhalers with better performance to enhance the therapeutic benefits; iii) enable wide availability of inexpensive and effective pharmaceutical inhalation products to the Australian community for the treatment of asthma and other diseases, iv) facilitate environmentally friendly technology since powder aerosol delivery does not require any harmful organic solvents to operate.Read moreRead less
Synthesis of nanoparticles by impinging liquid-jet precipitation for inhalation drug delivery. The project aim is to develop a state of the art technology for the efficient, reliable and economical production of nanoparticles of drugs suitable for inhalation delivery to the lung. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. The project will focus on both the production process and the particle properties for aerosol a ....Synthesis of nanoparticles by impinging liquid-jet precipitation for inhalation drug delivery. The project aim is to develop a state of the art technology for the efficient, reliable and economical production of nanoparticles of drugs suitable for inhalation delivery to the lung. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. The project will focus on both the production process and the particle properties for aerosol administration. Successful development of the technology will not only gain new knowledge in the key area of nanotechnology, but also lead to better inhalation therapy to benefit patients.Read moreRead less
Development of a novel process for the formation of particles with controlled surface architecture for respiratory drug delivery. A successful conclusion of this project will enhance substantially the competitiveness of Australia's research in functional nanomaterials and advanced biomaterials. The Australian pharmaceutical industry will gain through the ability to develop proprietary pharmaceutical formulations targeted towards taking advantage of the novel process. Patients of asthma, lung inf ....Development of a novel process for the formation of particles with controlled surface architecture for respiratory drug delivery. A successful conclusion of this project will enhance substantially the competitiveness of Australia's research in functional nanomaterials and advanced biomaterials. The Australian pharmaceutical industry will gain through the ability to develop proprietary pharmaceutical formulations targeted towards taking advantage of the novel process. Patients of asthma, lung infection and other serious health problems will benefit from an improved delivery of therapeutic dose at a much reduced cost. The technology is environmentally friendly as powder aerosol delivery does not require any harmful organic solvent to operate.Read moreRead less
High Gravity Precipitation of Nanoparticles for Pulmonary Drug Delivery. This collaborative project aims to explore the huge market potential of drug delivery by inhalation aerosols using nanoparticles. It will apply cutting edge nanotechnology to develop new techniques using high gravity to synthesise particles of biomaterials suitable for inhalation. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. Successful developme ....High Gravity Precipitation of Nanoparticles for Pulmonary Drug Delivery. This collaborative project aims to explore the huge market potential of drug delivery by inhalation aerosols using nanoparticles. It will apply cutting edge nanotechnology to develop new techniques using high gravity to synthesise particles of biomaterials suitable for inhalation. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. Successful development of the technology will position both Australia and the industry partner to take a lead in the application of this novel technology in pharmaceutical aerosols, and provides better inhalation therapy to benefit patients.Read moreRead less
Novel disinfection to combat antibiotic resistance . Control of antimicrobial resistance in water is critical. Disinfection in water and wastewater treatment plants is a vital barrier against antibiotic resistant bacteria (ARB); however, it is less effective in controlling- and may even facilitate the spread of antibiotic resistance genes (ARGs). This project aims to comprehensively investigate the effectiveness of widely-used disinfection processes in controlling ARB/ARGs, determine the underly ....Novel disinfection to combat antibiotic resistance . Control of antimicrobial resistance in water is critical. Disinfection in water and wastewater treatment plants is a vital barrier against antibiotic resistant bacteria (ARB); however, it is less effective in controlling- and may even facilitate the spread of antibiotic resistance genes (ARGs). This project aims to comprehensively investigate the effectiveness of widely-used disinfection processes in controlling ARB/ARGs, determine the underlying mechanisms, and identify optimal treatment conditions. This project also aims to develop a novel, cost-effective and environmentally friendly disinfection process for efficient ARGs destruction, thus significantly strengthening Australia’s capacity to prevent the spread of antibiotic resistance.Read moreRead less
Developing novel aerosol inhalers for pulmonary drug delivery from the fundamental understanding of powder dispersion mechanisms. The project seeks to understand how powder aerosol inhalers can be significantly improved. The outcome will provide therapeutic benefits to the Australian community for better treatment of respiratory diseases and facilitate environmentally friendly technology since these inhalers do not require any harmful organic solvents to operate.
Improving performance of solvent extraction equipment for the minerals processing industry. This project will develop a fundamental understanding of how a new type of solvent extraction column, which was recently introduced to the mining industry, responds to changes in process conditions and operating parameters. This will enable the potential for optimal and efficient use of these assets and ensure a competitive advantage for Australia's biggest export earner.
Terahertz Spectroscopy of Mass-Manufactured Viral Vaccines. The breakthrough vaccine for cervical cancer proves that new and exciting products are on the way to treat and protect against previously untouchable diseases. Similar products for bird flu are being researched, and new manufacturing methods are urgently needed to get this science to market at a price that people can afford. However, manufacturing innovation in the pharmaceutical industry is constrained by a lack of methods for product ....Terahertz Spectroscopy of Mass-Manufactured Viral Vaccines. The breakthrough vaccine for cervical cancer proves that new and exciting products are on the way to treat and protect against previously untouchable diseases. Similar products for bird flu are being researched, and new manufacturing methods are urgently needed to get this science to market at a price that people can afford. However, manufacturing innovation in the pharmaceutical industry is constrained by a lack of methods for product analysis. In this project engineers will devise advanced methods to fingerprint these new vaccine products, ensuring that manufacturing processes can be improved without compromising safety. These new analytical techniques will potentially lead to new low-cost vaccine products made in Australia.Read moreRead less
The elutriation of ultrafine particles according to their density. This study is concerned with exploiting a new and powerful mechanism for separating particles according to their density, with strong potential for recovering and concentrating tens of billions of dollars worth of valuable minerals annually. By coupling the new separation mechanism with a centrifugal force it should be possible to apply gravity separation technology, arguably for the first time, to the recovery of ultrafine parti ....The elutriation of ultrafine particles according to their density. This study is concerned with exploiting a new and powerful mechanism for separating particles according to their density, with strong potential for recovering and concentrating tens of billions of dollars worth of valuable minerals annually. By coupling the new separation mechanism with a centrifugal force it should be possible to apply gravity separation technology, arguably for the first time, to the recovery of ultrafine particles from 200 microns to well below 10 microns, at high separation efficiency, and high feed rates. This study is also ideal for training new researchers, especially at the PhD level, in an area of importance to Australia's economic future. Read moreRead less
Carbon-Supported Iron Catalysts for Selective Catalytic Reduction of NO. Nitric oxide (NO) is a major pollutant from combustion systems. This project aims to develop cost-effective and environmentally benign zerovalent iron catalysts supported on carbon material for selective catalytic reduction (SCR) of NO using CO and unburned hydrocarbons as in-situ reductants. By applying differential reactor experimentation, kinetic modelling and advanced material characterisation techniques, the research w ....Carbon-Supported Iron Catalysts for Selective Catalytic Reduction of NO. Nitric oxide (NO) is a major pollutant from combustion systems. This project aims to develop cost-effective and environmentally benign zerovalent iron catalysts supported on carbon material for selective catalytic reduction (SCR) of NO using CO and unburned hydrocarbons as in-situ reductants. By applying differential reactor experimentation, kinetic modelling and advanced material characterisation techniques, the research will unravel complex relationships among catalyst structural features and activity, NO reduction mechanisms, and catalyst performance under practically relevant combustion conditions that underpin the development of an effective yet affordable SCR technology to control NO emission from industrial utilities and automobiles.Read moreRead less