Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
Special Research Initiatives - Grant ID: SR0354908
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Insect-Plant Chemical Ecology Network (IPCEN). We bring together plant molecular biology, entomology and analytical chemistry to transform three leading fields of Australian research into an advanced science with far reaching capabilities in innovative research and applied outcomes. Expertise studying the biochemical pathways that produce specific plant compounds and expertise in insect recognition and response to these chemicals will be brought together. This will lead to new research outco ....The Insect-Plant Chemical Ecology Network (IPCEN). We bring together plant molecular biology, entomology and analytical chemistry to transform three leading fields of Australian research into an advanced science with far reaching capabilities in innovative research and applied outcomes. Expertise studying the biochemical pathways that produce specific plant compounds and expertise in insect recognition and response to these chemicals will be brought together. This will lead to new research outcomes and solutions to problems in agriculture, horticulture, forestry and protection of Australia's native flora. Researchers are struggling to create these links, constrained by disciplinary boundaries and geographical isolation. Key industries and researchers already support this proposal.Read moreRead less
Redefining the molecular mechanism underlying crustacean metamorphosis. This project uses the astonishing lifecycle of lobster larvae to better define the pathways and discover the key genes that regulate crustacean metamorphosis. Where, when, why and how metamorphosis occurs in crustaceans are important factors affecting fisheries recruitment and aquaculture production. The project suggests that the current accepted paradigm for the molecular control of metamorphosis does not apply to lobsters ....Redefining the molecular mechanism underlying crustacean metamorphosis. This project uses the astonishing lifecycle of lobster larvae to better define the pathways and discover the key genes that regulate crustacean metamorphosis. Where, when, why and how metamorphosis occurs in crustaceans are important factors affecting fisheries recruitment and aquaculture production. The project suggests that the current accepted paradigm for the molecular control of metamorphosis does not apply to lobsters and possibly other crustaceans where larval metamorphosis and the juvenile transformation are uncoupled. Using a unique supply of cultured lobsters and advanced molecular techniques, the project aims to develop tools to trigger and synchronise metamorphosis for use in aquaculture and invasive species management.Read moreRead less
Ecology, impacts and management of wild dogs in urbanising coastal landscapes of the wet tropics, Queensland. All management agencies and local governments in north Queensland identify wild dogs as a significant threat and a complex problem for management, and are in the process of developing wild dog management plans. However, these plans tend to be reactive and short-term, because too little is known to develop effective long-term management strategies. This project will provide a sound basis ....Ecology, impacts and management of wild dogs in urbanising coastal landscapes of the wet tropics, Queensland. All management agencies and local governments in north Queensland identify wild dogs as a significant threat and a complex problem for management, and are in the process of developing wild dog management plans. However, these plans tend to be reactive and short-term, because too little is known to develop effective long-term management strategies. This project will provide a sound basis for the development of such strategies. The results of the study will also inform wild dog management in many other parts of Australia that face similar problems.Read moreRead less
Lost at sea? Understanding adaptation and dispersal in spiny lobsters. Continual recruitment of young is fundamental to the replenishment of populations, especially when a stock is fished. Existing theory suggests that species with very long planktonic larval stages disperse widely, ensuring their genes are well mixed. However, recently identified genetic differences between populations of rock lobster challenge this paradigm and demonstrate that despite larvae mixing in the ocean for years, loc ....Lost at sea? Understanding adaptation and dispersal in spiny lobsters. Continual recruitment of young is fundamental to the replenishment of populations, especially when a stock is fished. Existing theory suggests that species with very long planktonic larval stages disperse widely, ensuring their genes are well mixed. However, recently identified genetic differences between populations of rock lobster challenge this paradigm and demonstrate that despite larvae mixing in the ocean for years, local recruitment and/or adaptation are at play. Recent developments in genomics and bioinformatics should allow this project to understand the ecological processes underpinning these genetic signatures and determine their evolutionary implications. Such findings could direct targeted rebuilding of depleted fisheries stocks.Read moreRead less
Developing a chlamydial vaccine for koalas. Developing a chlamydial vaccine for koalas . This project aims to produce an optimised, safe, field-tested, protective Chlamydia vaccine for koalas. In many regions of Australia, Chlamydia infection severely reduces female koala reproductive rates, threatening the species’ long term survival. This project builds on work developing a prototype vaccine for koala Chlamydia, and intends to produce a vaccine ready for potential registration and use by koala ....Developing a chlamydial vaccine for koalas. Developing a chlamydial vaccine for koalas . This project aims to produce an optimised, safe, field-tested, protective Chlamydia vaccine for koalas. In many regions of Australia, Chlamydia infection severely reduces female koala reproductive rates, threatening the species’ long term survival. This project builds on work developing a prototype vaccine for koala Chlamydia, and intends to produce a vaccine ready for potential registration and use by koala care centres, wildlife hospitals and government departments.Read moreRead less
Investigating the genetic basis for heterogeneous susceptibility of Tasmanian devils to a novel infectious cancer. This project will use genetics and modelling to reveal why Tasmanian devils in northwest Tasmania are not dying from facial tumour disease, a new, unusual infectious cancer threatening this iconic carnivore with extinction. This project will predict extinction risk, develop management options, and provide a new template for managing emerging wildlife diseases.
A Genome-wide Association Study In 2000 Glaucoma Cases With Matched Controls Using Equimoloar DNA Pools
Funder
National Health and Medical Research Council
Funding Amount
$610,267.00
Summary
Glaucoma is a common cause of loss of vision worldwide but we are unable to predict which people are at high risk of blindness. We aim to discover the genetic risk factors for glaucoma. We will use cutting edge genetic technology to assess the whole genome in thousands of patients with glaucoma. We hope to identify important new glaucoma genes, which could lead to the development of diagnostic tests and treatments which will provide the most cost-efficient ways to prevent glaucoma blindness.
Development of new tools for surveillance of chlamydial infections in sheep. This project aims to improve health in sheep and reduce on-farm losses for Australian producers, by developing new serological tests for chlamydial infections in sheep. These infections can result in significant on-farm losses and loss of trade in the live export industry. Currently, surveillance of chlamydial infections is hindered by outdated serological tools that are unreliable and difficult to interpret. The ser ....Development of new tools for surveillance of chlamydial infections in sheep. This project aims to improve health in sheep and reduce on-farm losses for Australian producers, by developing new serological tests for chlamydial infections in sheep. These infections can result in significant on-farm losses and loss of trade in the live export industry. Currently, surveillance of chlamydial infections is hindered by outdated serological tools that are unreliable and difficult to interpret. The serological tests to be developed aim to be species-specific tests to detect the most important chlamydial sheep pathogens. This in turn endeavours to improve domestic surveillance, reducing on-farm losses and costs, and improve market opportunities for Australian sheep exporters as well as informing veterinary populations on best practice treatment.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH120100032
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
Commercial development of rock lobster culture systems: the cutting edge of aquaculture. Commercial development of rock lobster culture systems: the cutting edge of aquaculture. This Research Hub will develop unique aquaculture systems, using novel engineering manufacture to mass produce lobster seed stock. A reliable, large-scale supply of seed will enable seacage culture, evaluation of wild stock enhancement and lead to sustainable food production.