Non-equilibrium reacting shock layers. This project aims is to study the non-equilibrium aerodynamic processes involved in hypervelocity flight. The design of vehicles for high speed flight is critically dependent on modelling the interactions between the flow field and the airframe, and the current lack of understanding is restricting the scope and benefit of viable activities in space. The expected outcomes include the ability to design optimised heat shields and air-frames with minimum mass a ....Non-equilibrium reacting shock layers. This project aims is to study the non-equilibrium aerodynamic processes involved in hypervelocity flight. The design of vehicles for high speed flight is critically dependent on modelling the interactions between the flow field and the airframe, and the current lack of understanding is restricting the scope and benefit of viable activities in space. The expected outcomes include the ability to design optimised heat shields and air-frames with minimum mass and maximum payload, precisely targeting specific flight conditions and vehicle shapes. The prospective benefits include increased productivity and reliability and reduced cost of missions to and from space, and a proliferation of new applications which this understanding will facilitate.Read moreRead less
Advancing the Science of Giant Planet Atmospheric Entry. This project aims to improve models used to design the heat shields which protect probes entering the atmospheres of the giant planets - four gaseous planets out beyond Mars. Further giant planet exploration is a key planetary science goal of the coming decade. However, the environment which an entry probe would experience features many unknowns and large uncertainties, making a mission a risky undertaking. Using unique experimental capabi ....Advancing the Science of Giant Planet Atmospheric Entry. This project aims to improve models used to design the heat shields which protect probes entering the atmospheres of the giant planets - four gaseous planets out beyond Mars. Further giant planet exploration is a key planetary science goal of the coming decade. However, the environment which an entry probe would experience features many unknowns and large uncertainties, making a mission a risky undertaking. Using unique experimental capabilities and state-of-the-art modelling, the expected project outcome is experimentally validated giant planet entry flow and surface chemistry models. This will allow more efficient heat shields to be designed while also increasing the chance of mission success, furthering our understanding of the universe.Read moreRead less
Next generation garbage collection: discovery, design, and development. This project aims to improve the performance of programming languages used by millions of Australians every day, such as Java, JavaScript and PHP by developing improved memory-management algorithms. These languages use what is referred to as “garbage collection” to ensure memory is managed without data loss, but do so conservatively and consequently cause performance challenges and energy overheads. This project expects to p ....Next generation garbage collection: discovery, design, and development. This project aims to improve the performance of programming languages used by millions of Australians every day, such as Java, JavaScript and PHP by developing improved memory-management algorithms. These languages use what is referred to as “garbage collection” to ensure memory is managed without data loss, but do so conservatively and consequently cause performance challenges and energy overheads. This project expects to provide these languages with improved memory-management algorithms, and provides researchers and industry with a framework for innovation. This project will enable safe software that is more efficient on today's hardware and able to exploit emerging hardware. This project should lead to better performance and energy savings for server applications, phones, watches, and smart appliances, while ensuring memory safety.Read moreRead less
Magnetohydrodynamic Aerobraking for Spacecraft Entry to Earth's Atmosphere. A spaceship returning from Mars will undergo unprecedented aerodynamic heating as it enters Earth's atmosphere. Magnetohydroynamic aerobraking involves applying a strong magnetic field to the plasma which forms around the spacecraft at these speeds, theoretically protecting it by reducing structural heat loads and enabling less severe flight trajectories. This project aims to experimentally study this technology for Eart ....Magnetohydrodynamic Aerobraking for Spacecraft Entry to Earth's Atmosphere. A spaceship returning from Mars will undergo unprecedented aerodynamic heating as it enters Earth's atmosphere. Magnetohydroynamic aerobraking involves applying a strong magnetic field to the plasma which forms around the spacecraft at these speeds, theoretically protecting it by reducing structural heat loads and enabling less severe flight trajectories. This project aims to experimentally study this technology for Earth return from deep space. It is significant because it will evaluate a new mechanism for managing the tremendous heat loads of planetary entry. The expected outcome and benefit will be development of a new technology to reduce spacecraft heating, leading to safer, more efficient, and potentially reusable spacecraft.Read moreRead less
Linear Formation Interferometry for Astrophysics and New Space Technologies. This project will prototype a new type of visible and infrared light interferometry: telescopes freely moving in a line 10s of metres in length and directing their light towards a central beam combiner. This is particularly well suited to sparse aperture optical interferometry from space, which can be used to resolve angular scales much finer than the world's largest monolithic telescopes. The ground based prototype wil ....Linear Formation Interferometry for Astrophysics and New Space Technologies. This project will prototype a new type of visible and infrared light interferometry: telescopes freely moving in a line 10s of metres in length and directing their light towards a central beam combiner. This is particularly well suited to sparse aperture optical interferometry from space, which can be used to resolve angular scales much finer than the world's largest monolithic telescopes. The ground based prototype will also be able to make a several key astrophysical observations of benchmark stars and stellar systems, including making precise polarimetric measurements of dust shells around bright stars.Read moreRead less
Human Leukocyte Antigen-A and -B regulation of Natural Killer cell function. The aim of this project is to determine how genetic variation in the genes encoding cell surface receptors expressed by innate lymphocytes and the molecules they recognise diversifies their capacity to sense and respond to infection. This knowledge is critical for understanding why there are intrinsic differences between individuals with respect to their capacity to respond to different types of infection and will ultim ....Human Leukocyte Antigen-A and -B regulation of Natural Killer cell function. The aim of this project is to determine how genetic variation in the genes encoding cell surface receptors expressed by innate lymphocytes and the molecules they recognise diversifies their capacity to sense and respond to infection. This knowledge is critical for understanding why there are intrinsic differences between individuals with respect to their capacity to respond to different types of infection and will ultimately inform our capacity to better deploy personalised medicines.Read moreRead less
GRACE follow-on: validation of measurements and initial results. This project aims to advance knowledge to quantify ongoing mass loss of Earth’s polar ice caps and glaciers, increases in sea level, and changes in continental water storage. The project expects to improve the capability to monitor changes on Earth using satellites and to enhance analysis by exploiting data from new instrumentation on the GRACE Follow-On space gravity mission, due for launch in 2018. Expected results aim to improve ....GRACE follow-on: validation of measurements and initial results. This project aims to advance knowledge to quantify ongoing mass loss of Earth’s polar ice caps and glaciers, increases in sea level, and changes in continental water storage. The project expects to improve the capability to monitor changes on Earth using satellites and to enhance analysis by exploiting data from new instrumentation on the GRACE Follow-On space gravity mission, due for launch in 2018. Expected results aim to improve computational tools and to develop expertise to analyse the new data. Other expected outcomes include reliable methods to monitor significant sea-level rise and associated societal and economic disruptions.Read moreRead less
Marsupial genomics: antimicrobial peptides and endangered species conservation. This project aims to use Australia’s unique biodiversity to tackle the global challenge of antimicrobial resistance. Rapid gene duplication and evolution of antimicrobial peptide genes in marsupials provide protection for joeys that are immunologically naïve in the pouch. By characterising immune genes in 10 marsupial species, this project will yield new antimicrobial peptides that can tackle superbugs. Genomic infor ....Marsupial genomics: antimicrobial peptides and endangered species conservation. This project aims to use Australia’s unique biodiversity to tackle the global challenge of antimicrobial resistance. Rapid gene duplication and evolution of antimicrobial peptide genes in marsupials provide protection for joeys that are immunologically naïve in the pouch. By characterising immune genes in 10 marsupial species, this project will yield new antimicrobial peptides that can tackle superbugs. Genomic information will also be used to provide significant benefits, such as improving the long term conservation of our endangered native species in a more appropriate and cost-effective way.Read moreRead less
Gene regulation by retroelement encoded natural antisense transcripts. Genetic information underpins all life on earth and is processed to make proteins, which determine the characteristics of an organism. However, only about 2% of our whole genome is made up of genes that encode proteins; the other 98% is non-coding and its function remains poorly understood. Aims and Significance: This proposal aims to utilise cutting edge genomic technologies to generate new knowledge about how the non-coding ....Gene regulation by retroelement encoded natural antisense transcripts. Genetic information underpins all life on earth and is processed to make proteins, which determine the characteristics of an organism. However, only about 2% of our whole genome is made up of genes that encode proteins; the other 98% is non-coding and its function remains poorly understood. Aims and Significance: This proposal aims to utilise cutting edge genomic technologies to generate new knowledge about how the non-coding genome regulates the expression of protein coding genes. Expected Outcomes and Benefits: This proposal will provide novel targets and methodology for gene modulation with broad applications from biology to environmental sciences.Read moreRead less
Investigating the evolution of innate and adaptive cellular immunity. This proposal aims to assess the impact of geographical and genetic isolation of the Australian Indigenous population on adaptive and innate immune systems. The project will use novel DNA sequencing approaches to generate the high resolution sequences of two genetic loci that regulate innate and adaptive immune responses, the major histocompatibility complex locus and the killer cell immunoglobulin-like receptor locus. In an i ....Investigating the evolution of innate and adaptive cellular immunity. This proposal aims to assess the impact of geographical and genetic isolation of the Australian Indigenous population on adaptive and innate immune systems. The project will use novel DNA sequencing approaches to generate the high resolution sequences of two genetic loci that regulate innate and adaptive immune responses, the major histocompatibility complex locus and the killer cell immunoglobulin-like receptor locus. In an initial screen, distinct variants and combinations of these genes were identified. This project aims to interrogate how variation in these critical genes impacts on the function of cytotoxic lymphocytes, providing insights into the evolutionary drivers of immune recognition mechanisms.Read moreRead less