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A knockout approach to identifying genes involved in epidermal development and homeostasis. These studies will identify new genes which play a role in the development or maintenance of the skin, some of which may subsequently be shown to play a role in disease. The project capitalises on an investment of tens of millions of dollars by the Wellcome Trust in generating a significant cohort of knockout mice. Our involvement in this international initiative will ensure Australia's participation in ....A knockout approach to identifying genes involved in epidermal development and homeostasis. These studies will identify new genes which play a role in the development or maintenance of the skin, some of which may subsequently be shown to play a role in disease. The project capitalises on an investment of tens of millions of dollars by the Wellcome Trust in generating a significant cohort of knockout mice. Our involvement in this international initiative will ensure Australia's participation in a project at the forefront of mouse genetics, using cutting edge infrastructure and technologies to provide insights into the complement of genes involved in skin biology. Models of interest will be repatriated to Australia for further study capitalising on existing infrastructure provided through the NCRIS funding program. Read moreRead less
Insect development : the role of cytochrome P450s. Pest insects vector human diseases such as malaria and impose a massive burden in agriculture due to control costs and production losses. The intelligent control of insect pests requires an understanding of their development that is controlled by hormones. This project will provide an in depth understanding of insect hormone synthesis/degradation that is controlled by a class of enzymes, the cytochrome P450s. This will increase the potential ....Insect development : the role of cytochrome P450s. Pest insects vector human diseases such as malaria and impose a massive burden in agriculture due to control costs and production losses. The intelligent control of insect pests requires an understanding of their development that is controlled by hormones. This project will provide an in depth understanding of insect hormone synthesis/degradation that is controlled by a class of enzymes, the cytochrome P450s. This will increase the potential for new insect-specific control strategies with a decreased environmental impact.Read moreRead less
Molecular, physiological and environmental regulation of toxic prussic acid levels (cyanogenesis) in forage sorghum. Forage sorghum is grown widely in dry, tropical areas of Australia. The leaves contain dhurrin, a natural defence product that liberates prussic acid (cyanide) when leaf tissue is disrupted (eg when chewed). The problem is that young plants or those experiencing drought are highly toxic, resulting in financial loss through reduced nutritive value, livestock loss and wasted feed. U ....Molecular, physiological and environmental regulation of toxic prussic acid levels (cyanogenesis) in forage sorghum. Forage sorghum is grown widely in dry, tropical areas of Australia. The leaves contain dhurrin, a natural defence product that liberates prussic acid (cyanide) when leaf tissue is disrupted (eg when chewed). The problem is that young plants or those experiencing drought are highly toxic, resulting in financial loss through reduced nutritive value, livestock loss and wasted feed. Using new, non-GM technology we will identify novel genetically altered sorghum lines with negligible prussic acid. Lines with enhanced levels could be used as soil biofumigants. Breeders can use this germplasm to develop varieties tailored for increasingly dry Australian conditions. The new varieties with controlled dhurrin content will be suitable for export.Read moreRead less
Dissecting the Indigo Pathway in Natural Indigo Producing Plants: Intricate Pathway Engineering for the Generation of Blue-Fibre Cotton. Australian cotton growers must maintain a sustained competitive advantage in the future to compete within the global cotton market by commanding higher margins for specialty cotton lint over and above current revenues. Development, via biotechnology, of naturally-colored, 'blue' lint cottons is the technical goal, where novel environmentally-benign textile prod ....Dissecting the Indigo Pathway in Natural Indigo Producing Plants: Intricate Pathway Engineering for the Generation of Blue-Fibre Cotton. Australian cotton growers must maintain a sustained competitive advantage in the future to compete within the global cotton market by commanding higher margins for specialty cotton lint over and above current revenues. Development, via biotechnology, of naturally-colored, 'blue' lint cottons is the technical goal, where novel environmentally-benign textile products could be produced without the use of toxic synthetic dyes or caustic dyeing processes. Success will provide a unique opportunity to re-establish an Australian cotton/textile industry by allowing direct participation in the development, branding and marketing of novel Australian textile products, generating potential revenue upwards of $10B/year. Read moreRead less
A bird's eye view of sex: the chicken embryo as a model for gonadal development. The development of an embryo as either male or female (sex determination) is a fundamental biological process that fascinates both scientific and lay communities alike. This project will use the chicken embryo as a unique model organism to study how genes control sex determination. We will bring a novel method to our field of study; the use of avian viruses to deliver genes into embryos. This project will enhance ou ....A bird's eye view of sex: the chicken embryo as a model for gonadal development. The development of an embryo as either male or female (sex determination) is a fundamental biological process that fascinates both scientific and lay communities alike. This project will use the chicken embryo as a unique model organism to study how genes control sex determination. We will bring a novel method to our field of study; the use of avian viruses to deliver genes into embryos. This project will enhance our understanding of a basic biological process. It will have application to the poultry industry, in terms of sex ratio manipulation. It will also aid in the diagnosis of humans born with sexual abnormalities. The project will consolidate Australia's standing as a world leader in the area of reproduction and development.Read moreRead less
Functional genetic analysis of wood formation genes in Eucalyptus. Eucalypts are the world's most important plantation hardwood species due to their superior wood characteristics and high growth rates that make them excellent carbon sequestration platforms. Australia is the custodian of the world's natural eucalypt resource and our results will assist in their sustainable use with the potential to transform the national forestry industry by helping to streamline tree improvement efforts. This wi ....Functional genetic analysis of wood formation genes in Eucalyptus. Eucalypts are the world's most important plantation hardwood species due to their superior wood characteristics and high growth rates that make them excellent carbon sequestration platforms. Australia is the custodian of the world's natural eucalypt resource and our results will assist in their sustainable use with the potential to transform the national forestry industry by helping to streamline tree improvement efforts. This will be achieved by increasing our understanding of the development and production of wood, which will lead to increased productivity (more and better quality wood from less land). Custom designed wood also holds much promise for the production of novel biopolymers and as a renewable source for improved biofuels.Read moreRead less
Understanding the control of male germ-line development by the germline-restrictive silencing factor in plants. The world population is currently increasing at an unprecedented rate, with a concomitant requirement to double the food production from the same amount of arable land. To ensure global political and social stability, equitably increasing sustainable food production without compromising environmental integrity remains a major challenge. This proposal investigates the molecular mechanis ....Understanding the control of male germ-line development by the germline-restrictive silencing factor in plants. The world population is currently increasing at an unprecedented rate, with a concomitant requirement to double the food production from the same amount of arable land. To ensure global political and social stability, equitably increasing sustainable food production without compromising environmental integrity remains a major challenge. This proposal investigates the molecular mechanisms underlying male germ line initiation and development in plants. Switching off male gamete development in some crop plants will create male sterile lines, which, when crossed with genetically distinct lines, will have the potential to produce hybrids that yield 20-30 percent more crop without additional inputs. Read moreRead less
Epigenetic programming of plant sperm cells. Most of the grains and seeds that form the world's food supply are the result of the successful functioning of sperm and egg cells during fertilisation. This proposal aims to investigate the nature of sperm cell genome programming in plants and unravel molecular processes that give these cells their unique identity. This innovative and challenging research will also provide an excellent opportunity for training the next generation of scientists. The o ....Epigenetic programming of plant sperm cells. Most of the grains and seeds that form the world's food supply are the result of the successful functioning of sperm and egg cells during fertilisation. This proposal aims to investigate the nature of sperm cell genome programming in plants and unravel molecular processes that give these cells their unique identity. This innovative and challenging research will also provide an excellent opportunity for training the next generation of scientists. The outcomes of this proposal will enhance Australia's international lead in this field and will pave the way toward the development of new approaches for sustaining and enhancing crop productivity under changing environmental conditions. Read moreRead less
Using integrated frontier and smart technologies to identify new drug targets for parasites causing major diseases in humans and animals. The national/community benefits are (1) enhanced focus on animal and human health biotechnology through the development of anti-parasite compounds and/or vaccines; (2) improved and sustainable control of important parasites with decreased risk of induction of drug resistance; (3) increased profitability of agricultural animal production; (4) consolidation of a ....Using integrated frontier and smart technologies to identify new drug targets for parasites causing major diseases in humans and animals. The national/community benefits are (1) enhanced focus on animal and human health biotechnology through the development of anti-parasite compounds and/or vaccines; (2) improved and sustainable control of important parasites with decreased risk of induction of drug resistance; (3) increased profitability of agricultural animal production; (4) consolidation of a technology platform for further applications in genomics and post-genomics of pathogens of global significance and construction of a pipeline for the validation of drug targets; (5) capturing the benefits from fundamental research and strengthening links between fundamental and applied research; (6) increasing the quality and quantity of scientifically skilled people in biotechnology.Read moreRead less
Automated, smart genomic data integration for the exploration of developmentally regulated molecules in parasites of major socioeconomic importance. The national/community benefits are (1) enhanced focus on animal and human health biotechnology through the development of safe anti-parasite compounds/vaccines; (2) improved and sustainable control of key parasites with decreased risk of induction of drug resistance; (3) increased profitability of agricultural animal production; (4) consolidation o ....Automated, smart genomic data integration for the exploration of developmentally regulated molecules in parasites of major socioeconomic importance. The national/community benefits are (1) enhanced focus on animal and human health biotechnology through the development of safe anti-parasite compounds/vaccines; (2) improved and sustainable control of key parasites with decreased risk of induction of drug resistance; (3) increased profitability of agricultural animal production; (4) consolidation of a technology platform for further applications in genomics and post-genomics of pathogens of global significance and construction of a pipeline for the validation of drug targets; (5) capturing the benefits from fundamental research and strengthening links between fundamental and applied research; (6) increasing the quality and quantity of scientifically skilled people in biotechnology.Read moreRead less