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Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease le ....Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease leading to the potential identification of new drug and vaccine targets. The methodologies and expertise developed will be used will be available to other research groups working on infectious diseases.Read moreRead less
Validating protozoa-specific drug targets using peptides from biodiverse gene fragment libraries. Cryptosporidium and the trypanosomes are protozoan parasites, which have a global impact on the health, survival and economic development of millions of people and animals world wide. New therapies for the diseases they cause are urgently required. We describe a novel means of identifying protozoa-specific peptides that will inhibit the formation of essential protein complexes, which have no effect ....Validating protozoa-specific drug targets using peptides from biodiverse gene fragment libraries. Cryptosporidium and the trypanosomes are protozoan parasites, which have a global impact on the health, survival and economic development of millions of people and animals world wide. New therapies for the diseases they cause are urgently required. We describe a novel means of identifying protozoa-specific peptides that will inhibit the formation of essential protein complexes, which have no effect on the mammalian host. Candidate peptides will then be used to validate these protein complexes as new targets for the development of peptide-based therapeutic compounds. This project will validate novel targets for the development of new treatments for these diseases.Read moreRead less